Aging Cell,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: July 27, 2023
Abstract
Current
research
on
human
aging
has
largely
been
guided
by
the
milestone
paper
“hallmarks
of
aging,”
which
were
first
proposed
in
seminal
2013
Lopez‐Otin
et
al.
Most
studies
have
focused
one
hallmark
at
a
time,
asking
whether
underlying
molecular
perturbations
are
sufficient
to
drive
process
and
its
associated
phenotypes.
More
recently,
researchers
begun
investigate
phenotypes
driven
concurrent
pathways
linked
not
but
multiple
hallmarks
they
present
different
patterns
organs
systems
over
time.
Indeed,
preliminary
results
suggest
that
more
complex
interactions
between
must
be
considered
addressed,
if
we
develop
interventions
successfully
promote
healthy
and/or
delay
aging‐associated
dysfunction
diseases.
Here,
summarize
some
latest
work
views
interplay
aging,
with
specific
focus
mitochondrial
dysfunction.
this
represents
significant
example
crosstalk
effects
an
intervention
targeted
may
others.
A
better
knowledge
these
interconnections,
their
cause‐effect
relationships,
spatial
temporal
sequence,
will
very
beneficial
for
whole
field
identification
effective
promoting
old
age.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: July 31, 2023
Multi-omics
usually
refers
to
the
crossover
application
of
multiple
high-throughput
screening
technologies
represented
by
genomics,
transcriptomics,
single-cell
proteomics
and
metabolomics,
spatial
so
on,
which
play
a
great
role
in
promoting
study
human
diseases.
Most
current
reviews
focus
on
describing
development
multi-omics
technologies,
data
integration,
particular
disease;
however,
few
them
provide
comprehensive
systematic
introduction
multi-omics.
This
review
outlines
existing
technical
categories
multi-omics,
cautions
for
experimental
design,
focuses
integrated
analysis
methods
especially
approach
machine
learning
deep
integration
corresponding
tools,
medical
researches
(e.g.,
cancer,
neurodegenerative
diseases,
aging,
drug
target
discovery)
as
well
open-source
tools
databases,
finally,
discusses
challenges
future
directions
precision
medicine.
With
algorithms,
important
disease
research,
also
provided
detailed
introduction.
will
guidance
researchers,
who
are
just
entering
into
research.
Molecular & Cellular Proteomics,
Journal Year:
2023,
Volume and Issue:
22(6), P. 100561 - 100561
Published: April 28, 2023
The
world
has
witnessed
a
steady
rise
in
both
non-infectious
and
infectious
chronic
diseases,
prompting
cross-disciplinary
approach
to
understand
treating
disease.
Current
medical
care
focuses
on
people
after
they
become
patients
rather
than
preventing
illness,
leading
high
costs
late-stage
diseases.
Additionally,
"one-size-fits
all"
health
does
not
take
into
account
individual
differences
genetics,
environment,
or
lifestyle
factors,
decreasing
the
number
of
benefiting
from
interventions.
Rapid
advances
omics
technologies
progress
computational
capabilities
have
led
development
multi-omics
deep
phenotyping,
which
profiles
interaction
multiple
levels
biology
over
time
empowers
precision
approaches.
This
review
highlights
current
emerging
modalities
for
discusses
applications
following
areas:
genetic
variation,
cardio-metabolic
cancer,
organ
transplantation,
pregnancy,
longevity/aging.
We
will
briefly
discuss
potential
approaches
disentangling
host-microbe
host-environmental
interactions.
touch
areas
electronic
record
clinical
imaging
integration
with
muti-omics
health.
Finally,
we
challenges
implementation
its
future
prospects.
Nature Aging,
Journal Year:
2022,
Volume and Issue:
3(1), P. 121 - 137
Published: Dec. 19, 2022
Abstract
The
diversity
of
cell
types
is
a
challenge
for
quantifying
aging
and
its
reversal.
Here
we
develop
‘aging
clocks’
based
on
single-cell
transcriptomics
to
characterize
cell-type-specific
rejuvenation.
We
generated
transcriptomes
from
the
subventricular
zone
neurogenic
region
28
mice,
tiling
ages
young
old.
trained
single-cell-based
regression
models
predict
chronological
age
biological
(neural
stem
proliferation
capacity).
These
clocks
are
generalizable
independent
cohorts
other
regions
brains,
species.
To
determine
if
these
could
quantify
transcriptomic
rejuvenation,
datasets
two
interventions—heterochronic
parabiosis
exercise.
Aging
revealed
that
heterochronic
exercise
reverse
in
regions,
but
different
ways.
This
study
represents
first
development
high-resolution
data
demonstrates
their
application
Molecular Psychiatry,
Journal Year:
2022,
Volume and Issue:
28(1), P. 242 - 255
Published: July 15, 2022
Aging
is
a
major
risk
factor
for
number
of
chronic
diseases,
including
neurodegenerative
and
cerebrovascular
disorders.
processes
have
therefore
been
discussed
as
potential
targets
the
development
novel
broadly
effective
preventatives
or
therapeutics
age-related
those
affecting
brain.
Mechanisms
thought
to
contribute
aging
summarized
under
term
"hallmarks
aging"
include
loss
proteostasis,
mitochondrial
dysfunction,
altered
nutrient
sensing,
telomere
attrition,
genomic
instability,
cellular
senescence,
stem
cell
exhaustion,
epigenetic
alterations
intercellular
communication.
We
here
examine
key
claims
about
aging".
Our
analysis
reveals
important
weaknesses
that
preclude
strong
definitive
conclusions
concerning
possible
role
these
in
shaping
organismal
rate.
Significant
ambiguity
arises
from
overreliance
on
lifespan
proxy
marker
aging,
use
models
with
unclear
relevance
study
designs
do
not
allow
properly
estimate
intervention
effects
also
discuss
future
research
directions
should
be
taken
clarify
if
what
extent
putative
regulators
fact
interact
aging.
These
multidimensional
analytical
frameworks
well
facilitate
proper
assessment
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Jan. 3, 2024
Ovarian
aging
occurs
prior
to
the
of
other
organ
systems
and
acts
as
pacemaker
process
multiple
organs.
As
life
expectancy
has
increased,
preventing
ovarian
become
an
essential
goal
for
promoting
extended
reproductive
function
improving
bone
genitourinary
conditions
related
in
women.
An
improved
understanding
may
ultimately
provide
tools
prediction
mitigation
this
process.
Recent
studies
have
suggested
a
connection
between
gut
microbiota,
alterations
composition
functional
profile
microbiota
profound
consequences
on
function.
The
interaction
ovaries
is
bidirectional.
In
review,
we
examine
current
knowledge
ovary-gut
crosstalk
further
discuss
potential
role
anti-aging
interventions.
Microbiota-based
manipulation
appealing
approach
that
offer
new
therapeutic
strategies
delay
or
reverse
aging.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: June 3, 2024
The
composition
of
the
human
gut
microbiome
has
been
observed
to
change
over
course
an
individual's
life.
From
birth,
it
is
shaped
by
mode
delivery,
diet,
environmental
exposures,
geographic
location,
exposures
medications,
and
aging
itself.
Here,
we
present
a
narrative
review
across
lifespan
with
focus
on
its
impacts
age-related
diseases
in
humans.
We
will
describe
how
shaped,
features
that
have
associated
at
different
phases
life
this
can
adversely
affect
healthy
aging.
Across
lifespan,
especially
old
age,
diverse
includes
organisms
suspected
produce
anti-inflammatory
metabolites
such
as
short-chain
fatty
acids,
reported
be
These
findings
remarkably
consistent
regions
world
suggesting
they
could
universal
all
cultures
genetic
backgrounds.
Exactly
these
biologic
processes
thus
promoting
crucial
targeting
for
interventions
support
health
longevity.
