Brain stimulation, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Low-intensity focused ultrasound (LIFU) is a promising form of non-invasive neuromodulation characterized by rich parameter space that includes intensity, duration, duty cycle and pulsing strategy. The effect interaction these parameters to affect human brain activity poorly understood. A better understanding how interact critical advance LIFU as potential therapeutic.
Language: Английский
eLife, Journal Year: 2023, Volume and Issue: 12
Published: Oct. 2, 2023
Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans (Fomenko et al., 2020). At the same time, parallel research line highlighted potentially confounding influence of peripheral auditory arising from pulsing audible frequencies. In this study, we disentangle direct and indirect contributions inhibitory effects TUS. To end, include tightly matched control conditions across four experiments, preregistered, conducted independently three institutions. We employed combined transcranial magnetic paradigm, where TMS-elicited motor-evoked potentials (MEPs) served an index corticospinal excitability. First, replicated but showed through both tight controls manipulation intensity, duration, masking that was driven by stimulation, not neuromodulation. Furthermore, consider beyond driving overall excitation/inhibition show preliminary evidence how might interact with ongoing neural dynamics instead. Primarily, study highlights substantial shortcomings accounting confound prior TUS-TMS work only flip-over sham no active used. The field must critically reevaluate previous findings given demonstrated impact confounds. rigorous experimental design via (in)active required make substantiated claims future studies. Only when are disentangled those confounds can fully realize its potential clinical
Language: Английский
Citations
19
Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. e1730232024 - e1730232024
Published: Jan. 18, 2024
The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal studies have revealed daily rhythms in neuronal activity SCN. However, of human SCN has remained elusive. In this study, to reveal diurnal variation humans, we localized by employing an areal boundary mapping technique resting-state functional images and investigated using perfusion imaging. first experiment (n = 27, including both sexes), scanned each participant four times a day, every six hours. Higher was observed at noon, while lower recorded early morning. second 20, measured thirty minutes hours from midnight dawn. results showed that gradually decreased not associated with electroencephalography. Furthermore, compatible rodent after switching off lights. These suggest follows zeitgeber cycles nocturnal mammals modulated physical lights rather than local time. Significance Statement hypothalamus mammals. elusive due difficulty measuring such small nucleus. MRI perfusion. We patterns higher daylight time night also during night,
Language: Английский
Citations
7
Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 56, P. 101370 - 101370
Published: March 8, 2024
The use of 'offline' transcranial ultrasound stimulation (TUS) protocols is particular interest in the rapidly growing field low-intensity TUS. Offline TUS can modulate neural activity up to several hours after stimulation, suggesting induction early-phase neuroplasticity. Studies both humans and nonhuman primates have shown spatially specific changes neuromodulation target a distributed network regions associated with it. These suggest that excitatory or inhibitory effects are result complex interaction between protocol used underlying brain region state. Understanding how neuroplasticity induced by offline could open avenues for influencing late-phase therapeutic applications wide range disorders.
Language: Английский
Citations
7
Journal of Neural Engineering, Journal Year: 2023, Volume and Issue: 20(1), P. 016043 - 016043
Published: Jan. 20, 2023
Background. Low-intensity transcranial ultrasound stimulation (TUS) could induce both immediate and long-lasting neuromodulatory effects in human brains. Interhemispheric imbalance at prefrontal or motor cortices generally associates with various cognitive decline aging mental disorders. However, whether TUS modulate the interhemispheric balance of excitability brain remains unknown.Objective. This study aims to explore repetitive (rTUS) intervention can between bilateral cortex (M1) healthy subjects.Approach. Motor evoked potentials (MEPs) M1 were measured 15 min 0 before a active sham rTUS on left min, 30 after intervention, Chinese version brief neurocognitive test battery (C-BCT) was conducted respectively. Cortical quantified by MEPs, changes MEP amplitude used as an index plasticity.Results. In group (n= 20), ipsilateral increased significantly compared baselines lasted for up while contralateral decreased lasting yielding laterality MEPs. Furthermore, induced some C-BCT scores, scores correlated amplitudes intervention. The 20) showed no significant MEPs scores. addition, participants reported any adverse during obvious temperature increase appeared skull tissues simulation.Significance. modulated plasticity brain, improved performance, suggesting considerable potential clinical interventions.
Language: Английский
Citations
15
Ultrasound in Medicine & Biology, Journal Year: 2023, Volume and Issue: 49(6), P. 1422 - 1430
Published: March 6, 2023
Language: Английский
Citations
13
IEEE Open Journal of Engineering in Medicine and Biology, Journal Year: 2023, Volume and Issue: 4, P. 300 - 318
Published: Jan. 1, 2023
Stroke as the leading cause of adult long-term disability and has a significant impact on patients, society socio-economics. Non-invasive brain stimulation (NIBS) approaches such transcranial magnetic (TMS) or electrical (tES) are considered potential therapeutic options to enhance functional reorganization augment effects neurorehabilitation. However, non-invasive paradigms limited by their depth focality trade-off function that does not allow target deep key structures critically important for recovery processes. Transcranial ultrasound (TUS) is an emerging approach neuromodulation. Using non-ionizing, ultrasonic waves with millimeter-accuracy spatial resolution, excellent steering capacity long penetration depth, TUS serve novel method establish unprecedented neuromodulation neurorehabilitation protocols. The purpose present review provide overview current knowledge about neuromodulatory while discussing in field stroke recovery, respect existing NIBS methods. We will address discuss crucial open questions remaining challenges need be addressed before establishing new clinical motor recovery.
Language: Английский
Citations
12
Psychiatry and Clinical Neurosciences, Journal Year: 2024, Volume and Issue: 78(5), P. 273 - 281
Published: March 20, 2024
Low‐intensity focused transcranial ultrasound stimulation (TUS) is an emerging noninvasive technique capable of stimulating both the cerebral cortex and deep brain structures with high spatial precision. This method recognized for its potential to comprehensively perturb various regions, enabling modulation neural circuits, in a manner not achievable through conventional magnetic or electrical techniques. The underlying mechanisms neuromodulation are based on phenomenon where mechanical waves kinetically interact neurons, specifically affecting neuronal membranes mechanosensitive channels. interaction induces alterations excitability neurons within stimulated region. In this review, we briefly present fundamental principles physics physiological TUS neuromodulation. We explain experimental apparatus procedures humans. Due focality, integration methods, including resonance imaging resonance–guided neuronavigation systems, important perform experiments precise targeting. then review current state literature neuromodulation, particular focus human subjects, targeting subcortical structures. Finally, outline future perspectives clinical applications psychiatric neurological fields.
Language: Английский
Citations
5
Brain stimulation, Journal Year: 2024, Volume and Issue: 17(4), P. 911 - 924
Published: July 1, 2024
The insula and dorsal anterior cingulate cortex (dACC) are core brain regions involved in pain processing central sensitization, a shared mechanism across various chronic conditions. Methods to modulate these may serve reduce though it is unclear which target be most efficacious for different measures of sensitization.
Language: Английский
Citations
5
eLife, Journal Year: 2024, Volume and Issue: 12
Published: Aug. 27, 2024
Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans (Fomenko et al., 2020). At the same time, parallel research line highlighted potentially confounding influence of peripheral auditory arising from pulsing audible frequencies. In this study, we disentangle direct and indirect contributions inhibitory effects TUS. To end, include tightly matched control conditions across four experiments, preregistered, conducted independently three institutions. We employed combined transcranial magnetic paradigm, where TMS-elicited motor-evoked potentials (MEPs) served an index corticospinal excitability. First, replicated but showed through both tight controls manipulation intensity, duration, masking that was driven by stimulation, not neuromodulation. Furthermore, consider beyond driving overall excitation/inhibition show preliminary evidence how might interact with ongoing neural dynamics instead. Primarily, study highlights substantial shortcomings accounting confound prior TUS-TMS work only flip-over sham no active used. The field must critically reevaluate previous findings given demonstrated impact confounds. rigorous experimental design via (in)active required make substantiated claims future studies. Only when are disentangled those confounds can fully realize its potential clinical
Language: Английский
Citations
5
The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(12), P. 2931 - 2943
Published: May 2, 2024
Abstract Theta‐burst transcranial ultrasound stimulation (tbTUS) increases primary motor cortex (M1) excitability for at least 30 min. However, the remote effects of focal M1 tbTUS on other cortical areas are unknown. Here, we examined left right excitability. An 80 s train active or sham was delivered to in 20 healthy subjects. Before and after tbTUS, measured: (1) corticospinal using motor‐evoked potential (MEP) amplitudes from single‐pulse magnetic (TMS) M1; (2) interhemispheric inhibition (IHI) a dual‐site paired‐pulse TMS paradigm; (3) intracortical circuits with short‐interval facilitation (ICF) TMS. Left decreased as shown by MEP amplitudes, increased ICF IHI hemisphere interstimulus interval (ISI) 10 ms but not long‐interval 40 ms. The study showed that can change inhibition. should be considered when it is used neuroscience research neuromodulation treatment brain disorders. image Key points Transcranial (TUS) novel non‐invasive technique advantages being able achieve high spatial resolution target deep structures. A repetitive TUS protocol, an theta burst patterned (tbTUS), has been increase excitability, well alpha beta movement‐related spectral power distinct regions. In this study, contralateral measured MEPs elicited stimulation. We left‐to‐right inhibition, M1. These results lead better understand help development neurological psychiatric disorders research.
Language: Английский
Citations
4