From NAFLD to HCC: Advances in noninvasive diagnosis DOI Open Access

Qinchen Xu,

Maoxiao Feng, Yidan Ren

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115028 - 115028

Published: June 16, 2023

Non-alcoholic fatty liver disease (NAFLD) has gradually become one of the major health problems in world. The dynamic course goes through steatosis, inflammation, fibrosis, and carcinoma. Before progressing to carcinoma, timely effective intervention will make condition better, which highlights importance early diagnosis. With further study biological mechanism pathogenesis progression NAFLD, some potential biomarkers have been discovered, possibility their clinical application is being discussed. At same time, progress imaging technology emergence new materials methods also provide more possibilities for diagnosis NAFLD. This article reviews diagnostic markers advanced NAFLD recent years.

Language: Английский

WFUMB Guidelines/Guidance on Liver Multiparametric Ultrasound. Part 2: Guidance on Liver Fat Quantification DOI Creative Commons
Giovanna Ferraioli, R. Graham Barr, Annalisa Berzigotti

et al.

Ultrasound in Medicine & Biology, Journal Year: 2024, Volume and Issue: 50(8), P. 1088 - 1098

Published: April 23, 2024

The World Federation for Ultrasound in Medicine and Biology (WFUMB) has promoted the development of this document on multiparametric ultrasound. Part 2 is a guidance use available tools quantification liver fat content with These are attenuation coefficient, backscatter speed sound. All them raw data ultrasound beam to estimate content. This aim helping reader understanding how they work interpret results. Confounding factors discussed standardized protocol measurement acquisition suggested mitigate them. recommendations were based published studies experts' opinion but not formally graded because body evidence remained low at time drafting document.

Language: Английский

Citations

34
Noninvasive assessment of liver fibrosis and its clinical significance in nonalcoholic fatty liver disease DOI
Nobuharu Tamaki, Masayuki Kurosaki, Daniel Q. Huang

et al.

Hepatology Research, Journal Year: 2022, Volume and Issue: 52(6), P. 497 - 507

Published: March 30, 2022

Abstract Liver fibrosis is the most important prognostic factor in patients with nonalcoholic fatty liver disease (NAFLD). Several noninvasive markers for fibrosis, including blood‐based and imaging based‐markers have been developed. Indirect (e.g., fibrosis‐4 index NAFLD score) consist of standard laboratory data clinical parameters. Given its availability high negative predictive value advanced these are suitable screening at primary care. Blood‐based fibrogenesis (enhanced N‐terminal propeptide type 3 collagen), ultrasound‐based modalities (vibration‐controlled transient elastography, point shear wave elastography [SWE], two‐dimensional SWE), magnetic resonance diagnostic accuracy diagnosing secondary care centers. Sequential use can increase reduce health costs. Furthermore, combining makers may assist identifying candidates pharmacological trials reducing failure. Emerging suggest that associated liver‐related events (hepatocellular carcinoma decompensation) mortality. delta change over time also time‐course event risk, mortality risk. However, association between cardiovascular (CVD) risk still controversial. CVD decrease decompensated be useful assessing patients. Therefore, utilized as measures well real‐time tools, place biopsy.

Language: Английский

Citations

47
Non-Invasive Imaging Methods to Evaluate Non-Alcoholic Fatty Liver Disease with Fat Quantification: A Review DOI Creative Commons
Weon Jang, Ji Soo Song

Diagnostics, Journal Year: 2023, Volume and Issue: 13(11), P. 1852 - 1852

Published: May 25, 2023

Hepatic steatosis without specific causes (e.g., viral infection, alcohol abuse, etc.) is called non-alcoholic fatty liver disease (NAFLD), which ranges from (NAFL) to steatohepatitis (NASH), fibrosis, and NASH-related cirrhosis. Despite the usefulness of standard grading system, biopsy has several limitations. In addition, patient acceptability intra- inter-observer reproducibility are also concerns. Due prevalence NAFLD limitations biopsies, non-invasive imaging methods such as ultrasonography (US), computed tomography (CT), magnetic resonance (MRI) that can reliably diagnose hepatic have developed rapidly. US widely available radiation-free but cannot examine entire liver. CT readily helpful for detection risk classification, significantly when analyzed using artificial intelligence; however, it exposes users radiation. Although expensive time-consuming, MRI measure fat percentage with proton density fraction (MRI-PDFF). Specifically, chemical shift-encoded (CSE)-MRI best indicator early detection. The purpose this review provide an overview each modality emphasis on recent progress current status quantification.

Language: Английский

Citations

27
Small Intestinal Bacterial Overgrowth and Non-Alcoholic Fatty Liver Disease: What Do We Know in 2023? DOI Open Access
Anna Gudan, Katarzyna Kozłowska‐Petriczko, Ewa Wunsch

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1323 - 1323

Published: March 8, 2023

Non-alcoholic fatty liver disease (NAFLD) is a chronic associated with the pathological accumulation of lipids inside hepatocytes. Untreated NAFL can progress to non-alcoholic hepatitis (NASH), followed by fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The common denominator above-mentioned metabolic disorders seems be insulin resistance, which occurs in NAFLD patients. Obesity greatest risk factor for lipid hepatocytes, but part patient population has normal body weight according BMI index. Obese people or without have higher incidence small intestinal bacterial overgrowth (SIBO), those suffering from show increased permeability, including more frequent presence intestine (SIBO). health consequences SIBO are primarily malabsorption (vitamin B12, iron, choline, fats, carbohydrates proteins) bile salt deconjugation. Undetected untreated may lead nutrient and/or energy malnutrition, thus directly impairing function (e.g., folic acid choline deficiency). However, whether contributes dysfunction, decreased barrier integrity, inflammation, endotoxemia translocation not yet clear. In this review, we focus on gut–liver axis discuss critical points, novel insights role nutrition, lifestyle, pre- probiotics, medication supplements therapy prevention both NAFLD.

Language: Английский

Citations

23
Non-invasive evaluation of liver steatosis with imaging modalities: New techniques and applications DOI Creative Commons
Keyu Zeng,

Wu-Yong-Ga Bao,

Yunhan Wang

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(17), P. 2534 - 2550

Published: May 5, 2023

In the world, nonalcoholic fatty liver disease (NAFLD) accounts for majority of diffuse hepatic diseases. Notably, substantial fat accumulation can trigger and accelerate fibrosis, thus contributing to progression. Moreover, presence NAFLD not only puts adverse influences but is also associated with an increased risk type 2 diabetes cardiovascular Therefore, early detection quantified measurement content are great importance. Liver biopsy currently most accurate method evaluation steatosis. However, has several limitations, namely, its invasiveness, sampling error, high cost moderate intraobserver interobserver reproducibility. Recently, various quantitative imaging techniques have been developed diagnosis content, including ultrasound- or magnetic resonance-based methods. These provide objective continuous metrics be recorded comparison when patients receive check-ups evaluate changes in which useful longitudinal follow-up. this review, we introduce describe their diagnostic performance content.

Language: Английский

Citations

22
KASL Clinical Practice Guidelines for Noninvasive Tests to Assess Liver Fibrosis in Chronic Liver Disease DOI Creative Commons

Mi Na Kim,

Ji Won Han,

Jihyun An

et al.

Clinical and Molecular Hepatology, Journal Year: 2024, Volume and Issue: 30(Suppl), P. S5 - S105

Published: Aug. 20, 2024

Language: Английский

Citations

6
Multivariable Quantitative US Parameters for Assessing Hepatic Steatosis DOI
Hidekatsu Kuroda,

Takuma Oguri,

Naohisa Kamiyama

et al.

Radiology, Journal Year: 2023, Volume and Issue: 309(1)

Published: Oct. 1, 2023

Background Because of the global increase in incidence nonalcoholic fatty liver disease, development noninvasive, widely available, and highly accurate methods for assessing hepatic steatosis is necessary. Purpose To evaluate performance models with different combinations quantitative US parameters their ability to predict at least 5% patients chronic disease (CLD) as defined using MRI proton density fat fraction (PDFF). Materials Methods Patients CLD were enrolled this prospective multicenter study between February 2020 April 2021. Integrated backscatter coefficient (IBSC), signal-to-noise ratio (SNR), US-guided attenuation parameter (UGAP) measured all participants. Participant PDFF value was used define steatosis. Four based on created: model 1 (UGAP alone), 2 IBSC), 3 SNR), 4 IBSC SNR). Diagnostic assessed area under receiver operating characteristic curve (AUC). The internally validated 1000 bootstrap samples. Results A total 582 participants included (median age, 64 years; IQR, 52-72 274 female participants). There 364 group 218 nonsteatosis group. AUC values diagnosis 1-4 0.92, 0.93, 0.95, 0.96, respectively. C-indexes adjusted by method Compared other models, demonstrated improved discrimination (P < .01). Conclusion built UGAP, IBSC, SNR could accurately discriminate CLD. © RSNA, 2023 Supplemental material available article. See also editorial Han issue.

Language: Английский

Citations

14
A comparative study of hepatic steatosis using two different qualitative ultrasound techniques measured based on magnetic resonance imaging‐derived proton density fat fraction DOI Creative Commons
Sadanobu Ogawa, Takashi Kumada, Tatsuya Gotoh

et al.

Hepatology Research, Journal Year: 2024, Volume and Issue: 54(7), P. 638 - 654

Published: Jan. 31, 2024

This study aimed to evaluate the diagnostic performance of attenuation measurement (ATT; dual-frequency method) and improved algorithm ATT (iATT; reference for assessment hepatic steatosis using magnetic resonance imaging (MRI)-derived proton density fat fraction (PDFF) as standard.

Language: Английский

Citations

5
Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal DOI Creative Commons
Dorotea Božić, Kristian Podrug, Ivana Mikolašević

et al.

Diagnostics, Journal Year: 2022, Volume and Issue: 12(10), P. 2287 - 2287

Published: Sept. 22, 2022

The prevalence of the non-alcoholic fatty liver disease has reached major proportions, being estimated to affect one-quarter global population. reference techniques, which include biopsy and magnetic resonance imaging proton density fat fraction, have objective practical financial limitations their routine use in detection quantification steatosis. Therefore, there been a rising necessity for development new inexpensive, widely applicable reliable non-invasive diagnostic tools. controlled attenuation parameter considered point-of-care technique assessment steatosis long period time. Recently, many ultrasound (US) system manufacturers developed proprietary software solutions Some these methods already extensively tested with very good performance results reported, while others are still under evaluation. This manuscript reviews currently available US-based diagnosing grading steatosis, including classification results, an appraisal importance this armamentarium daily clinical practice.

Language: Английский

Citations

20
Recent advances in noninvasive assessment of liver steatosis DOI Open Access
Giovanna Ferraioli, R. Graham Barr

Polskie Archiwum Medycyny Wewnętrznej, Journal Year: 2024, Volume and Issue: unknown

Published: March 18, 2024

Due to the steatosis epidemic, noninvasive quantification of liver fat content is great interest.Magnetic resonance (MR) techniques, including proton MR spectroscopy (MRS) and chemical shift imaging can quantify by measuring, directly or indirectly (the latter), density fraction (PDFF).They have shown excellent diagnostic accuracy are currently reference standard for assessment used in clinical trials evaluating change over time.Using ultrasound (US), three different quantitative parameters be obtained estimate fat: attenuation coefficient, backscatter speed sound.Controlled parameter(CAP), which estimates US beam, was first algorithm available performed with a non-imaging system.Currently, several other algorithms on B-mode systems, they an similar higher than CAP.This article reports current knowledge about their application patients metabolic dysfunction-associated steatotic disease.

Language: Английский

Citations

4