Integration and differentiation of hippocampal memory traces

Neuroscience & Biobehavioral Reviews, Journal Year: 2020, Volume and Issue: 118, P. 196 - 208

Published: July 23, 2020

Language: Английский

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vmPFC Drives Hippocampal Processing during Autobiographical Memory Recall Regardless of Remoteness

Cerebral Cortex, Journal Year: 2020, Volume and Issue: 30(11), P. 5972 - 5987

Published: June 2, 2020

Abstract Our ability to recall past experiences, autobiographical memories (AMs), is crucial cognition, endowing us with a sense of self and underwriting our capacity for autonomy. Traditional views assume that the hippocampus orchestrates event recall, whereas recent accounts propose ventromedial prefrontal cortex (vmPFC) instigates coordinates hippocampal-dependent processes. Here we sought characterize dynamic interplay between vmPFC during AM adjudicate these perspectives. Leveraging high temporal resolution magnetoencephalography, found left showed greatest power changes retrieval. Moreover, responses in preceded activity initiation except retrieval most AMs. The drove hippocampal also as AMs unfolded over subsequent seconds, this effect was evident regardless age. These results recast positions hierarchy, implications theoretical memory processing systems-level consolidation.

Language: Английский

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Memory consolidation as an adaptive process

Psychonomic Bulletin & Review, Journal Year: 2021, Volume and Issue: 28(6), P. 1796 - 1810

Published: July 29, 2021

Language: Английский

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Meta‐analytic and functional connectivity evidence from functional magnetic resonance imaging for an anterior to posterior gradient of function along the hippocampal axis

Hippocampus, Journal Year: 2019, Volume and Issue: 30(5), P. 456 - 471

Published: Oct. 7, 2019

Abstract There is considerable evidence from non‐human animal studies that the anterior and posterior regions of hippocampus have different anatomical connections support behavioural functions. Although there are some recent human using functional magnetic resonance imaging (fMRI) addressed this idea directly in memory spatial processing domains provided for it, has been no broader meta‐analysis fMRI literature to determine if consistent dissociations across all cognitive which participates. The purpose review address gap our knowledge three approaches. One approach involved PubMed searches identify relevant papers reporting hippocampal activation during episodic encoding retrieval, semantic working memory, navigation, simulation/scene construction, transitive inference, social cognition tasks. second was use a large meta‐analytic database (neurosynth) find text terms coactivation maps associated with identified search. third contrast resting‐state connectivity publicly available includes sample adults. These approaches converging not only processes differently distributed along axis, but also distinct areas coactivated functionally connected segments. This anterior/posterior distinction involving multiple provides strong long axis hippocampus.

Language: Английский

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Changes in patterns of neural activity underlie a time‐dependent transformation of memory in rats and humans

Hippocampus, Journal Year: 2018, Volume and Issue: 28(10), P. 745 - 764

Published: July 10, 2018

Abstract The dynamic process of memory consolidation involves a reorganization brain regions that support trace over time, but exactly how the network reorganizes as changes remains unclear. We present novel converging evidence from studies animals (rats) and humans for time‐dependent transformation different types measured both by behavior activation. find context‐specific memories in rats, naturalistic episodic humans, lose precision time activity hippocampus decreases. If, however, retrieved retain contextual or perceptual detail, is engaged similarly at recent remote timepoints. As interval between timepoint increases, medial prefrontal cortex increasingly during retrieval, regardless context amount detail. Moreover, these hippocampal‐frontal shifts are accompanied corresponding cortical structures mediating perceptually‐detailed well less precise, schematic memories. These findings provide cross‐species crucial interplay neocortex reflects representation underlies systems consolidation.

Language: Английский

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Sleep Spindles Promote the Restructuring of Memory Representations in Ventromedial Prefrontal Cortex through Enhanced Hippocampal–Cortical Functional Connectivity

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 40(9), P. 1909 - 1919

Published: Jan. 20, 2020

Memory consolidation is hypothesized to involve the distribution and restructuring of memory representations across hippocampal cortical regions. Theories suggest that, through extended hippocampal–cortical interactions, ensembles come represent more integrated, or overlapping, traces that prioritize commonalities related memories. Sleep processes, particularly fast sleep spindles, are thought support consolidation, but evidence for this relationship has been mostly limited retention benefits. Whether spindles provide a mechanism neural changes including strengthening networks integration representations, remains unclear, as does specificity regions involved. Using functional connectivity analyses human fMRI data (both sexes), we show spindle density during overnight enhanced next day, when restudying information learned before sleep. Spindle modulated in distinct depending on category consolidated stimuli. Specifically, correlated with between anterior hippocampus ventromedial prefrontal cortex (vmPFC) object–word pairs, posterior posteromedial scene–word pairs. multivariate pattern analyses, also postlearning associated greater similarity, representational overlap, individual memories vmPFC day. Further, overlap was mediated by degree hippocampal–vmPFC connectivity. Together, these results network traces, potentially vmPFC. SIGNIFICANCE STATEMENT How new experiences transformed into long-term fundamental question neuroscience research. stabilized they reorganized brain, process be supported oscillations, spindles. Although have benefits retention, it not well understood how modify traces. This study found correlate increased similarity among cortex. The critical may act physiological

Language: Английский

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Spatial scaffold effects in event memory and imagination

Wiley Interdisciplinary Reviews Cognitive Science, Journal Year: 2018, Volume and Issue: 9(4)

Published: Feb. 27, 2018

Spatial context is a defining feature of episodic memories, which are often characterized as being events occurring in specific spatiotemporal contexts. In this review, I summarize research suggesting common neural basis for and spatial memory relate to the role memory. review evidence that serves scaffold imagination, terms both behavioral effects demonstrating dependence on representations. These mediated by posterior‐medial set neocortical regions, including parahippocampal cortex, retrosplenial posterior cingulate precuneus, angular gyrus, interact with hippocampus represent remembered imagined events. highlight questions areas require further research, differentiation hippocampal function along its long axis subfields, how these network. This article categorized under: Psychology > Memory Neuroscience Cognition

Language: Английский

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From cognitive maps to spatial schemas

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 24(2), P. 63 - 79

Published: Nov. 21, 2022

Language: Английский

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Systems consolidation, transformation and reorganization: Multiple Trace Theory, Trace Transformation Theory and their Competitors

Published: May 10, 2021

We review the literature on systems consolidation by providing a brief history of field to place current research in proper perspective. cover both humans and non-humans, which are highly related despite differences techniques tasks that used. argue understanding interactions between hippocampus neocortex (and other structures) underlie consolidation, depend appreciating close correspondence psychological neural representations memory, as postulated Multiple Trace Theory Transformation Theory. end evaluating different theories light evidence we reviewed suggest concept with its central concern time-limited role plays may have outlived usefulness. replacing it program processes mechanisms changes memory across lifetime – natural change.

Language: Английский

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Schemas provide a scaffold for neocortical integration of new memories over time

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 2, 2022

Memory transformation is increasingly acknowledged in theoretical accounts of systems consolidation, yet how memory quality and neural representation change over time schemas influence this process remains unclear. We examined the behavioral schema-congruent incongruent object-scene pairs retrieved across 10-minutes 72-hours using fMRI. When a congruent schema was available, became coarser time, aided by post-encoding coupling between anterior hippocampus medial prefrontal cortex (mPFC). Only representations were integrated mPFC organized according to schematic context. In hippocampus, pattern similarity changed such that posterior represented specific details general context memories, irrespective congruency. Our findings suggest are used as scaffold facilitate neocortical integration information, illustrate evolution hippocampal organization detailed contextual time.

Language: Английский

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