The oral microbiota and periodontal health in orthodontic patients DOI Creative Commons
B.W. Peterson, Geerten‐Has E. Tjakkes,

Anne‐Marie Renkema

et al.

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Abstract The oral microbiota develops within the first 2 years of childhood and becomes distinct from parents by 4 years‐of‐age. plays an important role in overall health/symbiosis individual. Deviations state symbiosis leads to dysbiosis increased risk pathogenicity. can occur not only daily life activities but also orthodontic interventions. Orthodontic appliances are formed a variety biomaterials. Once inserted, they serve as breeding ground for microbial attachment, new surface areas crevices material physicochemical interactions different than symbiotic state. Individuals undergoing treatment show, compared with untreated people, qualitative quantitative differences activity microbiota, induced retention supra‐ subgingival plaque throughout period. These changes at root main undesirable effects, such gingivitis, white spot lesions (WSL), more severe caries lesions. Notably, profile weeks intervention might be valuable indicator predict identify higher‐risk individuals respect periodontal health otherwise healthy population. Antimicrobial coatings have been used dissuade microbes adhering biomaterial; however, disrupt host several bacterial strains become resistant. Smart biomaterials that reduce antimicrobial load preventing adhesion shown promising results, their complexity has kept many solutions reaching clinic. 3D printing technology provides opportunities complex chemical syntheses performed uniformly, reducing cost producing smart giving hope may reach clinic near future. purpose this review is emphasize importance during therapy use innovative technologies better maintain its balance surgical procedures.

Language: Английский

Advances in chitosan-based drug delivery systems: A comprehensive review for therapeutic applications DOI

Ammar Haider,

Shabana I. Khan, Dure Najaf Iqbal

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 210, P. 112983 - 112983

Published: March 26, 2024

Language: Английский

Citations

52
Marine algal polysaccharides for drug delivery applications: A review DOI

Nada E Ramadan,

Fatma Youssef,

Amira A K Alshishtawy

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139551 - 139551

Published: Jan. 7, 2025

Language: Английский

Citations

2
Magnesium metal–organic framework microneedles loaded with curcumin for accelerating oral ulcer healing DOI Creative Commons
Junhui Liu, Zhipeng Zhang,

Xiufei Lin

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 30, 2024

Language: Английский

Citations

14
Separable nanocomposite hydrogel microneedles for intradermal and sustained delivery of antigens to enhance adaptive immune responses DOI

Yanting Zheng,

Zhiming Li, Shaohua Li

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 185, P. 203 - 214

Published: July 23, 2024

Language: Английский

Citations

9
Treatment of periodontal disease: does drug delivery matter? DOI Creative Commons

Tarcílio Lima de Sousa,

Douglas Dourado, Júlia Soares Rodrigues

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: July 16, 2024

Graphical Abstract

Language: Английский

Citations

6
Microneedle system for tissue engineering and regenerative medicines: a smart and efficient therapeutic approach DOI
Muhammad Umar Aslam Khan,

Muhammad Azhar Aslam,

Mohd Faizal Abdullah

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 16(4), P. 042005 - 042005

Published: Aug. 9, 2024

The global demand for an enhanced quality of life and extended lifespan has driven significant advancements in tissue engineering regenerative medicine. These fields utilize a range interdisciplinary theories techniques to repair structurally impaired or damaged tissues organs, as well restore their normal functions. Nevertheless, the clinical efficacy medications, materials, potent cells used at laboratory level is always constrained by technological limitations. A novel platform known adaptable microneedles been developed address abovementioned issues. offer solution localized distribution various cargos while minimizing invasiveness. Microneedles provide favorable patient compliance settings due effective administration ability painless convenient process. In this review article, we summarized most recent development microneedles, started classifying microneedle systems, advantages, fundamental properties. Subsequently, it provides comprehensive overview different types material fabricate properties ideal applications medicine, primarily focusing on preserving restoring organs. limitations perspectives have discussed concluding future therapeutic medicines.

Language: Английский

Citations

6
Hydrogel-Forming Microneedles in the Management of Dermal Disorders Through a Non-Invasive Process: A Review DOI Creative Commons
Popat Mohite, Abhijeet Puri, Shubham Munde

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 719 - 719

Published: Nov. 7, 2024

Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (HFMNs) represent transformative advancement management of diseases through non-invasive drug delivery. These innovative devices consist micrometer-sized needles made native or crosslinked hydrophilic polymers, capable penetrating stratum corneum without damaging underlying tissues. Upon insertion, HFMNs rapidly absorb interstitial fluid, swelling form hydrogel conduit that enables efficient transport directly into microcirculation. The nature enhances patient compliance by eliminating pain and discomfort associated with traditional hypodermic needles. This allows delivery wide range drugs, including macromolecules biomacromolecules, which are often difficult administer dermally due their size polarity. Moreover, provide controlled regulated release profiles, enabling sustained effects while minimizing systemic side effects. Additionally, can be used both real-time fluid monitoring, valuable insights disease states treatment responses. dual functionality positions versatile dermatology tool effectively addressing complications. review explores use polymeric biomaterials HFMN fabrication application major disorders, such acne, psoriasis, other skin Furthermore, highlights MN-based treatments, underscoring reduce improve adherence, supported recent literature.

Language: Английский

Citations

6
Recent Advances in Functional Hydrogels for Treating Dental Hard Tissue and Endodontic Diseases DOI

Huixu Li,

Ding Zhang, Pingping Bao

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16395 - 16412

Published: June 14, 2024

Oral health is the basis of human health, and almost everyone has been affected by oral diseases. Among them, endodontic disease one most common Limited characteristics biomaterials, clinical methods for treatment still face large challenges in terms reliability stability. The hydrogel a kind good biomaterial with an adjustable 3D network structure, excellent mechanical properties, biocompatibility widely used basic research disease. This Review discusses recent advances functional hydrogels dental hard tissue treatment. emphasis on working principles therapeutic effects treating different diseases hydrogels. Finally, opportunities applications are discussed proposed. Some viewpoints about possible development direction future also put forward. Through systematic analysis conclusion treatment, this may provide significant guidance inspiration future.

Language: Английский

Citations

5
Recent advances in the preparation of microneedle patches for interstitial fluid extraction and analysis DOI
Xinyi Zhang,

Wenqin Zhang,

Wanhui Wu

et al.

Microchemical Journal, Journal Year: 2023, Volume and Issue: 195, P. 109477 - 109477

Published: Oct. 11, 2023

Language: Английский

Citations

13
The Synergistic Potential of Hydrogel Microneedles and Nanomaterials: Breaking Barriers in Transdermal Therapy DOI Open Access

Atefeh Golshirazi,

Mahsa Mohammadzadeh, Sheyda Labbaf

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Abstract The stratum corneum, which acts as a strong barrier against external agents, presents significant challenge to transdermal drug delivery. In this regard, microneedle (MN) patches, designed modern systems for delivery via permeation through the skin with ability pass are known be convenient, painless, and effective. fact, MN have shown breakthroughs in delivery, among various types, hydrogel (HMNs) demonstrated desirable inherent properties. Despite advancements, issues such limited loading capacity, uncontrolled release rates, non‐uniform therapeutic approaches persist. Conversely, nanomaterials (NMs) promise medical applications, however, their efficacy applicability constrained by challenges including poor stability, low bioavailability, payload rapid clearance immune system. Incorporation of NMs within HMNs offers new prospects address associated NMs. This combination can provide promising field research improved effective agents mitigate certain adverse effects, addressing current clinical concerns. review highlights use diagnostic applications.

Language: Английский

Citations

4