Cell transplantation therapy for spinal cord injury

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(5), P. 637 - 647

Published: April 25, 2017

Language: Английский

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A new mechanism of nervous system plasticity: activity-dependent myelination

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(12), P. 756 - 767

Published: Nov. 20, 2015

Language: Английский

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Intrinsic Control of Axon Regeneration

Neuron, Journal Year: 2016, Volume and Issue: 90(3), P. 437 - 451

Published: May 1, 2016

Language: Английский

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Moving beyond the glial scar for spinal cord repair

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Aug. 28, 2019

Abstract Traumatic spinal cord injury results in severe and irreversible loss of function. The triggers a complex cascade inflammatory pathological processes, culminating formation scar. While traditionally referred to as glial scar, the scar fact comprises multiple cellular extracellular components. This multidimensional nature should be considered when aiming understand role scarring limiting tissue repair recovery. In this Review we discuss recent advances understanding composition phenotypic characteristics oversimplification defining binary terms good or bad, development therapeutic approaches target components enable improved functional outcome after injury.

Language: Английский

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Intrinsic mechanisms of neuronal axon regeneration

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(6), P. 323 - 337

Published: April 17, 2018

Language: Английский

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Cell biology of spinal cord injury and repair

Journal of Clinical Investigation, Journal Year: 2017, Volume and Issue: 127(9), P. 3259 - 3270

Published: July 23, 2017

Spinal cord injury (SCI) lesions present diverse challenges for repair strategies. Anatomically complete injuries require restoration of neural connectivity across lesions. incomplete may benefit from augmentation spontaneous circuit reorganization. Here, we review SCI cell biology, which varies considerably three different lesion-related tissue compartments: (a) non-neural lesion core, (b) astrocyte scar border, and (c) surrounding spared but reactive tissue. After SCI, axon growth reorganization are determined by neuron-cell-autonomous mechanisms interactions among neurons, glia, immune other cells. These shaped both the presence absence growth-modulating molecules, vary markedly in compartments. The emerging understanding how biology differs compartments is fundamental to developing rationally targeted

Language: Английский

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Spinal cord repair: advances in biology and technology

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(6), P. 898 - 908

Published: June 1, 2019

Language: Английский

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Current and novel polymeric biomaterials for neural tissue engineering

Journal of Biomedical Science, Journal Year: 2018, Volume and Issue: 25(1)

Published: Dec. 1, 2018

The nervous system is a crucial component of the body and damages to this system, either by injury or disease, can result in serious potentially lethal consequences. Restoring damaged great challenge due complex physiology limited regenerative capacity.Polymers, synthetic natural origin, have been extensively evaluated as solution for restoring functions neural tissues. Polymers offer wide range versatility, particular regarding shape mechanical characteristics, their biocompatibility unmatched other biomaterials, such metals ceramics. Several studies shown that polymers be shaped into suitable support structures, including nerve conduits, scaffolds, electrospun matrices, capable improving regeneration In general, advantage better bioactivity, while non-natural properties structural stability. Often, combinations two allow development polymeric conduits able mimic native physiological environment healthy tissues and, consequently, regulate cell behaviour injured tissues.Currently, most tissue engineering applications are pre-clinical study, use central however collagen polymer aimed at peripheral nerves already successfully tested clinical trials.This review highlights different types used advantages disadvantages regeneration.

Language: Английский

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Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(11), P. 2698 - 2698

Published: May 31, 2019

Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial phase in the pathophysiological process of SCI concerns well-known secondary injury, which is uncontrolled and destructive cascade occurring later with aberrant molecular signaling, inflammation, vascular changes, cellular dysfunctions. use mesenchymal stem cells (MSCs) represents one important promising tested strategies. Their appeal, among other sources types cells, increased because their ease isolation/preservation properties. Nevertheless, encouraging promise from preclinical studies was followed by weak conflicting results clinical trials. In this review, therapeutic role MSCs discussed, together properties, application, limitations, future perspectives.

Language: Английский

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Dissecting spinal cord regeneration

Nature, Journal Year: 2018, Volume and Issue: 557(7705), P. 343 - 350

Published: May 8, 2018

Language: Английский

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