Chronic Sleep Deprivation Blocks Voluntary Morphine Consumption but Not Conditioned Place Preference in Mice DOI Creative Commons
Darrell Eacret, Crystal O. Lemchi, Jasmine I. Caulfield

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Feb. 17, 2022

The opioid epidemic remains a significant healthcare problem and is attributable to over 100,000 deaths per year. Poor sleep increases sensitivity pain, impulsivity, inattention, negative affect, all of which might perpetuate drug use. Opioid users have disrupted during use withdrawal report poor as reason for relapse. However, preclinical studies investigating the relationship between loss substance associated underlying neurobiological mechanisms potential interactions are lacking. One most common forms in modern society chronic short (CSS) (<7 h/nightly adults). Here, we used an established model CSS investigate influence on reward male mice. paradigm did not increase corticosterone levels or depressive-like behavior after single deprivation session but expression Iba1, typically reflects microglial activation, hypothalamus 4 weeks CSS. Rested control mice developed morphine preference 2-bottle choice test, while exposed develop preference. Both groups demonstrated conditioned place (mCPP), there were no differences rested Taken together, our results show that recovery disruption lessens voluntary intake, without impacting with morphine.

Language: Английский

Brain mechanisms of insomnia: new perspectives on causes and consequences DOI
Eus J.W. Van Someren

Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(3), P. 995 - 1046

Published: Aug. 13, 2020

While insomnia is the second most common mental disorder, progress in our understanding of underlying neurobiological mechanisms has been limited. The present review addresses definition and prevalence explores its subjective objective characteristics across 24-hour day. Subsequently, extensively how vulnerability to develop affected by genetic variants, early life stress, major events, brain structure function. Further supported clear health risks conveyed insomnia, integrated findings suggest that could rather be found circuits regulating emotion arousal than involved circadian homeostatic sleep regulation. Finally, a testable model presented. proposes people with locus coeruleus more sensitive to-or receives input from-the salience network related circuits, even during rapid eye movement sleep, when it should normally sound asleep. This may ignite downward spiral insufficient overnight adaptation distress, resulting accumulating hyperarousal, which, turn, impedes restful moreover increases risk other adversity. Sensitized are likely subjectively experienced as "sleeping one open". proposed opens up possibility for novel intervention studies animal studies, thus accelerating ignition neuroscience which direly needed better treatment.

Language: Английский

Citations

345
Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states DOI
William J. Giardino, Ada Eban-Rothschild, Daniel J. Christoffel

et al.

Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(8), P. 1084 - 1095

Published: July 19, 2018

Language: Английский

Citations

225
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive DOI Open Access
Ada Eban-Rothschild, Lior Appelbaum, Luı́s de Lecea

et al.

Neuropsychopharmacology, Journal Year: 2017, Volume and Issue: 43(5), P. 937 - 952

Published: Dec. 5, 2017

Language: Английский

Citations

219
The origins and evolution of sleep DOI Open Access
Alex C. Keene, Erik R. Duboué

Journal of Experimental Biology, Journal Year: 2018, Volume and Issue: 221(11)

Published: June 1, 2018

ABSTRACT Sleep is nearly ubiquitous throughout the animal kingdom, yet little known about how ecological factors or perturbations to environment shape duration and timing of sleep. In diverse taxa, poor sleep negatively impacts development, cognitive abilities longevity. addition mammals, has been characterized in genetic model organisms, ranging from nematode worm zebrafish, and, more recently, emergent models with simplified nervous systems such as Aplysia jellyfish. addition, evolutionary fruit flies cavefish have leveraged natural variation investigate relationship between ecology Here, we describe contributions classical mechanisms underlying regulation. These studies highlight fundamental interactions sensory processing, well a remarkable plasticity response environmental changes. Understanding varies kingdom will provide critical insight into functions conserved Furthermore, identification naturally occurring regulating may novel drug targets approaches treat sleep-related diseases.

Language: Английский

Citations

196
The Temperature Dependence of Sleep DOI Creative Commons
Edward C. Harding, Nicholas P. Franks, William Wisden

et al.

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: April 24, 2019

Mammals have evolved a range of behavioural and neurological mechanisms that coordinate cycles thermoregulation sleep. Whether diurnal or nocturnal, sleep onset reduction in core temperature occur together. Non-rapid eye movement (NREM) episodes are also accompanied by brain cooling. Thermoregulatory behaviours, like nest building curling up, accompany this circadian decline preparation for sleeping. This could be matter simply comfort as animals seek warmth to compensate lower temperatures. However, both humans other mammals, direct skin warming can shorten sleep-latency promote NREM We discuss the evidence body cooling more fundamentally connected thermoregulatory prior sleep, form warm microclimates accelerate directly through neuronal circuits. Paradoxically, might induce vasodilation In way, seeking nesting behaviour enhance cycle activating specific circuits link initiation suggest these explain why is most likely when at its steepest rate transitions decrease temperature. connection may implications energy homeostasis function

Language: Английский

Citations

173
Sleep disturbance in PTSD and other anxiety-related disorders: an updated review of clinical features, physiological characteristics, and psychological and neurobiological mechanisms DOI Open Access
Anne Richards,

Jennifer C. Kanady,

Thomas C. Neylan

et al.

Neuropsychopharmacology, Journal Year: 2019, Volume and Issue: 45(1), P. 55 - 73

Published: Aug. 23, 2019

Language: Английский

Citations

155
Brain clearance is reduced during sleep and anesthesia DOI Creative Commons
Andawei Miao, Tianyuan Luo, Bryan Hsieh

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(6), P. 1046 - 1050

Published: May 13, 2024

It has been suggested that the function of sleep is to actively clear metabolites and toxins from brain. Enhanced clearance also said occur during anesthesia. Here, we measure movement fluorescent molecules in brains male mice show is, fact, independent wake or Moreover, brain markedly reduced, not increased,

Language: Английский

Citations

54
A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus DOI Creative Commons
Edward C. Harding, Xiao Yu, Andawei Miao

et al.

Current Biology, Journal Year: 2018, Volume and Issue: 28(14), P. 2263 - 2273.e4

Published: July 1, 2018

Mammals, including humans, prepare for sleep by nesting and/or curling up, creating microclimates of skin warmth. To address whether external warmth induces through defined circuitry, we used c-Fos-dependent activity tagging, which captures populations activated cells and allows them to be reactivated test their physiological role. External warming tagged two principal groups neurons in the median preoptic (MnPO)/medial (MPO) hypothalamic area. GABA located mainly MPO produced non-rapid eye movement (NREM) but no body temperature decrease. Nitrergic-glutamatergic MnPO-MPO induced both cooling NREM sleep. This circuitry explains how why maximal rate core positively correlates with onset. Thus, pathways that promote sleep, reduced energy expenditure, are inextricably linked, commanded same neurons. implies one function is lower brain conserve energy.

Language: Английский

Citations

115
Sleep and thermoregulation DOI Creative Commons
Edward C. Harding, Nicholas P. Franks, William Wisden

et al.

Current Opinion in Physiology, Journal Year: 2019, Volume and Issue: 15, P. 7 - 13

Published: Nov. 26, 2019

In homeothermic animals sleep preparatory behaviours often promote thermal efficiency, including warmth-seeking, adopting particular postures (curling up, head tucking) and nest building, all promoting warmer skin microclimates. Skin warmth induces NREM body cooling via circuitry that connects sensation to the preoptic hypothalamus. Coupling induction lower temperature could serve minimise energy expenditure or allow reallocation. Cooling during may also induce transcriptional changes in genes whose products facilitate housekeeping functions measure time spent sleeping.

Language: Английский

Citations

79
Edinger-Westphal peptidergic neurons enable maternal preparatory nesting DOI Creative Commons
Thomas Topilko, Silvina L. Diaz, Catarina M. Pacheco

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(8), P. 1385 - 1399.e8

Published: Feb. 4, 2022

Optimizing reproductive fitness in mammalians requires behavioral adaptations during pregnancy. Maternal preparatory nesting is an essential behavior for the survival of upcoming litter. Brain-wide immediate early gene mapping mice evoked by sequences revealed that phases nest construction strongly activate peptidergic neurons Edinger-Westphal nucleus pregnant mice. Genetic ablation, bidirectional neuromodulation, and vitro vivo activity recordings demonstrated these are to modulate arousal before sleep promote specifically. We show enable effects progesterone on modulating a broad network downstream targets. Our study deciphers role midbrain CART+ pregnancy vital fitness.

Language: Английский

Citations

47