Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 22, 2024
Meal
timing
emerges
as
a
crucial
factor
influencing
metabolic
health
that
can
be
explained
by
the
tight
interaction
between
endogenous
circadian
clock
and
homeostasis.
Mistimed
food
intake,
such
delayed
or
nighttime
consumption,
leads
to
desynchronization
of
internal
is
associated
with
an
increased
risk
for
obesity
disturbances
type
2
diabetes
cardiovascular
diseases.
Conversely,
meal
aligned
cellular
rhythms
optimize
performance
tissues
organs.
In
this
review,
we
provide
overview
effects
discuss
underlying
mechanisms.
Additionally,
explore
factors
timing,
including
determinants
chronotype
genetics,
well
external
influences
like
social
factors,
cultural
aspects,
work
schedules.
This
review
could
contribute
defining
meal-timing-based
recommendations
public
initiatives
developing
guidelines
effective
lifestyle
modifications
targeting
prevention
treatment
Furthermore,
it
sheds
light
on
must
considered
in
design
future
intervention
trials.
Journal of Clinical Investigation,
Journal Year:
2018,
Volume and Issue:
128(6), P. 2157 - 2167
Published: May 31, 2018
All
species
organize
behaviors
to
optimally
match
daily
changes
in
the
environment,
leading
pronounced
activity/rest
cycles
that
track
light/dark
cycle.
Endogenous,
approximately
24-hour
circadian
rhythms
brain,
autonomic
nervous
system,
heart,
and
vasculature
prepare
cardiovascular
system
for
optimal
function
during
these
anticipated
behavioral
cycles.
Cardiovascular
rhythms,
however,
may
be
a
double-edged
sword.
The
normal
amplified
responses
morning
aid
transition
from
sleep
activity,
but
such
exaggerated
are
potentially
perilous
individuals
susceptible
adverse
events.
Indeed,
occurrence
of
stroke,
myocardial
infarction,
sudden
cardiac
death
all
have
patterns,
striking
most
frequently
morning.
Furthermore,
chronic
disruptions
clock,
as
with
night-shift
work,
contribute
increased
risk.
Here
we
highlight
importance
disease,
identify
opportunities
optimizing
timing
medications
disease.
New England Journal of Medicine,
Journal Year:
2021,
Volume and Issue:
384(6), P. 550 - 561
Published: Feb. 10, 2021
Molecular
insights
into
diurnal
variations
in
human
physiology
and
behavior
are
extending
our
understanding
of
a
wide
range
disease
processes.
Chronobiology
is
also
providing
testable
hypotheses
regarding
the
timing
treatments.
Nutrients,
Journal Year:
2019,
Volume and Issue:
11(4), P. 719 - 719
Published: March 28, 2019
The
influence
of
meal
frequency
and
timing
on
health
disease
has
been
a
topic
interest
for
many
years.
While
epidemiological
evidence
indicates
an
association
between
higher
frequencies
lower
risk,
experimental
trials
have
shown
conflicting
results.
Furthermore,
recent
prospective
research
demonstrated
significant
increase
in
risk
with
high
(≥6
meals/day)
as
compared
to
low
(1–2
meals/day).
Apart
from
we
also
consider
breakfast
consumption
the
distribution
daily
energy
intake,
caloric
restriction,
night-time
eating.
A
central
role
this
complex
scenario
is
played
by
fasting
period
length
two
meals.
physiological
underpinning
these
interconnected
variables
may
be
through
internal
circadian
clocks,
food
that
asynchronous
natural
rhythms
exert
adverse
effects
risk.
Additionally,
alterations
potential
macronutrient
intake.A
regular
pattern
including
consumption,
consuming
proportion
early
day,
reduced
(i.e.,
2–3
meals/day),
periods
provide
benefits
such
inflammation,
improved
rhythmicity,
increased
autophagy
stress
resistance,
modulation
gut
microbiota
Diabetologia,
Journal Year:
2020,
Volume and Issue:
63(3), P. 462 - 472
Published: Jan. 8, 2020
The
circadian
system
generates
endogenous
rhythms
of
approximately
24
h,
the
synchronisation
which
are
vital
for
healthy
bodily
function.
timing
many
physiological
processes,
including
glucose
metabolism,
coordinated
by
system,
and
disruptions
that
desynchronise
or
misalign
these
can
result
in
adverse
health
outcomes.
In
this
review,
we
cover
role
its
disruption
metabolism
individuals
with
type
2
diabetes
mellitus.
We
begin
defining
then
provide
an
overview
regulation
metabolism.
next
discuss
impact
on
control
diabetes.
Given
concurrent
high
prevalence
disruption,
understanding
mechanisms
underlying
may
aid
improving
glycaemic
control.
Obesity,
Journal Year:
2019,
Volume and Issue:
27(8), P. 1244 - 1254
Published: July 24, 2019
Eating
earlier
in
the
daytime
to
align
with
circadian
rhythms
metabolism
enhances
weight
loss.
However,
it
is
unknown
whether
these
benefits
are
mediated
through
increased
energy
expenditure
or
decreased
food
intake.
Therefore,
this
study
performed
first
randomized
trial
determine
how
meal
timing
affects
24-hour
when
intake
and
frequency
matched.
European Journal of Neuroscience,
Journal Year:
2018,
Volume and Issue:
51(1), P. 531 - 550
Published: Nov. 7, 2018
The
circadian
system
regulates
physiology
and
behavior.
Acute
challenges
to
the
system,
such
as
those
experienced
when
traveling
across
time
zones,
will
eventually
result
in
re-synchronization
local
environmental
cues,
but
this
is
oftentimes
accompanied
by
adverse
short-term
consequences.
When
are
chronically,
adaptation
may
not
be
achieved,
for
example
case
of
rotating
night
shift
workers.
transient
chronic
disturbance
most
frequently
referred
"circadian
disruption",
many
other
terms
have
been
proposed
used
refer
similar
situations.
It
now
beyond
doubt
that
contributes
health
disease,
emphasizing
need
clear
terminology
describing
their
goal
review
provide
an
overview
describe
disruption
discuss
quantifications
experimental
observational
settings
with
a
focus
on
human
research,
highlight
limitations
currently
available
tools.
For
research
advance
translational
science,
clear,
operationalizable,
scalable
key,
they
enable
improved
assessment
reproducibility
results,
ideally
ranging
from
mechanistic
settings,
including
animal
large-scale
randomized
clinical
trials.
