Emergent spatial goals in an integrative model of the insect central complex DOI Creative Commons
Roman Goulard, Stanley Heinze, Barbara Webb

et al.

PLoS Computational Biology, Journal Year: 2023, Volume and Issue: 19(12), P. e1011480 - e1011480

Published: Dec. 18, 2023

The insect central complex appears to encode and process spatial information through vector manipulation. Here, we draw on recent insights into circuit structure fuse previous models of sensory-guided navigation, path integration memory. Specifically, propose that the allocentric encoding location provided by creates a spatially stable anchor for converging sensory signals is relevant in multiple behavioural contexts. reference frame given transforms goal direction demonstrate modelling it can enhance approach target noisy, cluttered environments or with temporally sparse stimuli. We further show same improve performance more navigational task route following. model suggests specific functional roles elements helps explain their high preservation across species.

Language: Английский

A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection DOI Creative Commons
Brad K. Hulse, Hannah Haberkern, Romain Franconville

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Oct. 26, 2021

Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron microscopy-based connectome of

Language: Английский

Citations

304
Transforming representations of movement from body- to world-centric space DOI
Jenny Lu, Amir H. Behbahani,

Lydia Hamburg

et al.

Nature, Journal Year: 2021, Volume and Issue: 601(7891), P. 98 - 104

Published: Dec. 15, 2021

Language: Английский

Citations

107
Neural circuit mechanisms underlying context-specific halting in Drosophila DOI Creative Commons

Neha Sapkal,

Nino Mancini,

Divya Sthanu Kumar

et al.

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 191 - 200

Published: Oct. 2, 2024

Language: Английский

Citations

18
Mechanisms Underlying the Neural Computation of Head Direction DOI Open Access
Brad K. Hulse, Vivek Jayaraman

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 43(1), P. 31 - 54

Published: Dec. 24, 2019

Many animals use an internal sense of direction to guide their movements through the world. Neurons selective head are thought support this directional and have been found in a diverse range species, from insects primates, highlighting evolutionary importance. Across most head-direction networks share four key properties: unique representation at all times, persistent activity absence movement, integration angular velocity update representation, cues correct drift. The dynamics theorized network structures called ring attractors elegantly account for these properties, but relationship brain circuits is unclear. Here, we review experiments rodents flies that offer insights into potential neural implementations attractor networks. We suggest theory-guided search across model systems biological mechanisms enable such would uncover general principles underlying circuit function.

Language: Английский

Citations

105
Idiosyncratic neural coding and neuromodulation of olfactory individuality in Drosophila DOI Open Access
Kyle S. Honegger, M. A. Smith, Matthew A. Churgin

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 117(38), P. 23292 - 23297

Published: Aug. 27, 2019

Significance Individuality is a fundamental feature of behavior. For instance, the same smell or song may evoke very different responses in 2 individuals. What biological basis for these differences? While behavioral differences likely originate with neural activity, little known about how idiosyncratic are reflected activity. We used statistical analysis and live brain imaging to assess odor fruit flies, found that odors produce across flies subtly patterns activity flies. Moreover, neuromodulators sets neurons olfactory region fly’s directly modulate degree fly-to-fly variability flexible way.

Language: Английский

Citations

77
Neural circuit mechanisms for steering control in walkingDrosophila DOI Creative Commons

Aleksandr Rayshubskiy,

Stephen L. Holtz,

Alexander Shakeel Bates

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: April 5, 2020

Abstract Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Language: Английский

Citations

72
Flexible navigational computations in the Drosophila central complex DOI
Yvette E. Fisher

Current Opinion in Neurobiology, Journal Year: 2022, Volume and Issue: 73, P. 102514 - 102514

Published: Feb. 19, 2022

Language: Английский

Citations

56
Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions DOI Creative Commons
Dick R. Nässel, Meet Zandawala

Open Biology, Journal Year: 2022, Volume and Issue: 12(7)

Published: July 1, 2022

Plasticity in animal behaviour relies on the ability to integrate external and internal cues from changing environment hence modulate activity synaptic circuits of brain. This context-dependent neuromodulation is largely based non-synaptic signalling with neuropeptides. Here, we describe select peptidergic systems Drosophila brain that act at different levels a hierarchy associated physiology. These regions, such as central complex mushroom bodies, which supervise specific behaviours. At top level there are small numbers large neurons arborize widely multiple areas orchestrate or global state manner. bottom local provide executive sensory gain intrinsically restricted parts neuronal circuits. The orchestrating receive interoceptive signals mediate energy sleep homeostasis, metabolic circadian timing, well affect food search, aggression mating. Some these can be triggers conflicting behaviours mating versus aggression, feeding, participate circuits, enabling choices switches.

Language: Английский

Citations

56
Wind gates olfaction-driven search states in free flight DOI
S. David Stupski, Floris van Breugel

Current Biology, Journal Year: 2024, Volume and Issue: 34(19), P. 4397 - 4411.e6

Published: July 26, 2024

Language: Английский

Citations

12
Driver lines for studying associative learning in Drosophila DOI Creative Commons
Yichun Shuai, Megan Sammons, Gabriella R Sterne

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 29, 2025

The mushroom body (MB) is the center for associative learning in insects. In Drosophila , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult .

Language: Английский

Citations

1