Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 387, P. 119519 - 119519
Published: May 27, 2025
Language: Английский
Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 107, P. 253 - 264
Published: Oct. 12, 2022
Language: Английский
Citations
82
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(7), P. 2223 - 2240
Published: Feb. 28, 2024
In-utero exposure to maternal psychological distress is increasingly linked with disrupted fetal and neonatal brain development long-term neurobehavioral dysfunction in children adults. Elevated associated changes structure function, including reduced hippocampal cerebellar volumes, increased cerebral cortical gyrification sulcal depth, decreased metabolites (e.g., choline creatine levels), functional connectivity. After birth, gray matter gyrification, altered amygdala disturbed microstructure connectivity have been reported the offspring months or even years after during pregnancy. Additionally, adverse child neurodevelopment outcomes such as cognitive, language, learning, memory, social-emotional problems, neuropsychiatric are being prenatal distress. The mechanisms by which influences early include but not limited impaired placental epigenetic regulation, microbiome inflammation, dysregulated hypothalamic pituitary adrenal axis, distribution of cardiac output brain, sleep appetite. This review will appraise available literature on structural neurodevelopmental pregnant women experiencing elevated In addition, it also provide an overview mechanistic underpinnings stress response discuss current treatments for distress, pharmacotherapy selective serotonin reuptake inhibitors) non-pharmacotherapy cognitive-behavior therapy). Finally, end a consideration future directions field.
Language: Английский
Citations
25
Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)
Published: Oct. 9, 2021
Abstract Early exposure to psychosocial adversity is among the most potent predictors of depression. Because depression commonly emerges prior adulthood, we must consider fundamental principles developmental neuroscience when examining how experiences childhood adversity, including abuse and neglect, can lead Considering that both environment brain are highly dynamic across period spanning gestation through adolescence, purpose this review discuss integrate stress-based models center processes. We offer a general framework for understanding in early life disrupts or calibrates biobehavioral systems implicated Specifically, propose sources nature environmental input shaping brain, mechanisms neuroplasticity involved, change development. contend effects largely depend on stage organism. First, summarize leading neurobiological focus risk mental disorders, In particular, highlight allostatic load, acceleration maturation, dimensions sensitive critical s. Second, expound evidence formulation distinct depending timing adverse experiences, inherent within certain windows development constraints these experiences. Finally, other important facets (e.g., unpredictability, perceptions one’s experiences) before discussing promising research directions future field.
Language: Английский
Citations
63
Biological Psychiatry, Journal Year: 2022, Volume and Issue: 93(5), P. 430 - 441
Published: Nov. 9, 2022
Language: Английский
Citations
60
Biological Psychiatry, Journal Year: 2022, Volume and Issue: 93(10), P. 942 - 952
Published: Dec. 24, 2022
Language: Английский
Citations
58
Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(2), P. 139 - 148
Published: April 12, 2022
Language: Английский
Citations
43
Science Advances, Journal Year: 2022, Volume and Issue: 8(42)
Published: Oct. 19, 2022
Developmental and evolutionary effects on brain organization are complex, yet linked, as evidenced by the correspondence in cortical area expansion across these vastly different time scales. However, it is still not possible to study concurrently ontogeny phylogeny of areal connections, which arguably more relevant function than allometric measurements. Here, we propose a novel framework that allows integration structural connectivity maps from humans (adults neonates) nonhuman primates (macaques) onto common space. We use white matter bundles anchor space uniqueness connection patterns probe specialization. This enabled us quantitatively divergences similarities over developmental scales, reveal maturation trajectories, including effect premature birth, translate atlases between diverse brains. Our findings open new avenues for an integrative approach imaging neuroanatomy.
Language: Английский
Citations
31
Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 53, P. 101055 - 101055
Published: Dec. 27, 2021
The field of adult neuroimaging relies on well-established principles in research design, imaging sequences, processing pipelines, as well safety and data collection protocols. infant magnetic resonance imaging, by comparison, is a young with tremendous scientific potential but continuously evolving standards. present article aims to initiate constructive dialog between researchers who grapple the challenges inherent limitations nascent reviewers evaluate their work. We address 20 questions that commonly receive from ethics boards, grant, manuscript related collection, protocols, study planning, decisions software hardware, sharing, while acknowledging both accomplishments areas much needed future advancements. This reflects cumulative knowledge experts FIT'NG community can act resource for alike seeking deeper understanding standards tradeoffs involved neuroimaging.
Language: Английский
Citations
34
Stress, Journal Year: 2022, Volume and Issue: 25(1), P. 189 - 212
Published: Jan. 2, 2022
Systematically review existing evidence to (1) identify the association between self-report stress and cortisol levels measured during pregnancy; and, (2) assess their with adverse infant outcomes determine which is better predictor. A systematic was conducted in accordance PRISMA guidelines. Search terms focused on pregnancy, psychological cortisol. Nine electronic databases were searched, addition reference lists of relevant papers. Eligibility criteria consisted studies that included measurement self-reported stress, assessed associations any infant-related outcome. Further limits published English or Spanish human female participants. meta-regression not feasible due differences study samples, tools employed, types reported. narrative synthesis provided. 28 eligible for inclusion. Convergent validity measures reported by three (range r = 0.12–0.41). Higher significantly associated intrauterine growth restriction (fetal biparietal diameter, low fetal head circumference, abdominal circumference), gestational age at birth, anthropometric (birth length, length neonate), poor neurodevelopment (cognitive development) potentially pathogenic gut microbiota (Clostridiaceae Clostridium, Haemophilus) six studies. birth weight, (attention scores Network Neurobehavioral Scale) protective (Lactobacillus, Slackia Actinobaculum) 13 Of type measure a predictor (n 6), there agreement statistically predicting than stress. Self-report appear be modest predictors comparison number methodological limitations need addressed future help understand relationship how they are related outcomes.
Language: Английский
Citations
28
Development and Psychopathology, Journal Year: 2021, Volume and Issue: 33(5), P. 1526 - 1538
Published: Dec. 1, 2021
Abstract The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications mental health. Maternal distress signals are dominant early life influence, contributing birth outcomes risk offspring psychopathology. This prospective longitudinal study evaluated association between maternal infant white matter microstructure. Participants included racially socioeconomically diverse sample of 85 mother–infant dyads. Prenatal was assessed at 17 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) 42–45 postconceptional age. Findings demonstrated that higher GA associated increased fractional anisotropy, b = .283, t (64) 2.319, p .024, axial diffusivity, .254, 2.067, .043, within right anterior cingulate tract. No other significant associations found exposure tract anisotropy or diffusivity GA, earlier in gestation.
Language: Английский
Citations
28