Developmental trajectories of EEG aperiodic and periodic components in children 2–44 months of age

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 10, 2024

Abstract The development of neural circuits has long-lasting effects on brain function, yet our understanding early circuit in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected 592 healthy 2–44 month-old infants, revealing age-dependent nonlinear changes suggestive distinct milestones maturation. Developmental peaks include (1) the presence then absence a 9-10 Hz alpha peak between 2-6 months, (2) high beta (20-30 Hz) 4-18 (3) emergence low (12-20 some infants after six months age. We hypothesized that may reflect maturation thalamocortical network development. Infant anesthesia studies observe GABA-modulating anesthetics do not induce mediated frontal coherence until 10-12 Using small cohort ( n = 23) with before during anesthesia, we provide preliminary evidence have higher anesthesia-induced compared to those without peak.

Language: Английский

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Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation

Epilepsia, Journal Year: 2024, Volume and Issue: 65(5), P. 1360 - 1373

Published: March 22, 2024

Abstract Objectives Responsive neurostimulation (RNS) is an established therapy for drug‐resistant epilepsy that delivers direct electrical brain stimulation in response to detected epileptiform activity. However, despite overall reduction seizure frequency, clinical outcomes are variable, and few patients become seizure‐free. The aim of this retrospective study was evaluate aperiodic electrophysiological activity, associated with excitation/inhibition balance, as a novel electrographic biomarker aid early prognostication the RNS. Methods We identified intractable mesial temporal lobe who were implanted RNS System between 2015 2021 at University Utah. parameterized neural power spectra from intracranial recordings during first 3 months following implantation into periodic components. then correlated circadian changes parameters baseline most recent follow‐up. Results Seizure significantly patient's average change day/night exponent ( r = .50, p .016, n 23 patients) oscillatory alpha .45, .042, across recordings. reached its maximum nighttime hours (12 a.m. 6 a.m.) responders (i.e., least 50% seizures). Significance These findings suggest modulation broadband activity therapy. This marker has potential identify likely respond Furthermore, we propose less may be related dysfunction balance interconnected role epilepsy, sleep, memory.

Language: Английский

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Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

Published: March 13, 2025

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Language: Английский

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The maturation of aperiodic EEG activity across development reveals a progressive differentiation of wakefulness from sleep

NeuroImage, Journal Year: 2023, Volume and Issue: 277, P. 120264 - 120264

Published: July 1, 2023

During development, the brain undergoes radical structural and functional changes following a posterior-to-anterior gradient, associated with profound of cortical electrical activity during both wakefulness sleep. However, systematic assessment developmental effects on aperiodic EEG maturation across vigilance states is lacking, particularly regarding its topographical aspects. Here, in population 160 healthy infants, children teenagers (from 2 to 17 years, 10 subjects for each year), we investigated development Specifically, parameterized shape background Power Spectral Density (PSD) by means spectral exponent offset; reflects rate exponential decay power over increasing frequencies offset an estimate y-intercept PSD. We found that sleep caused EEG-PSD rotate opposite directions: PSD showed flatter reduced while it steeper higher as becomes deeper. deep (N2, N3) only decreased age, indexing broad-band voltage reduction. As result, difference between values those light (N1) increased suggesting progressive differentiation from activity, most prominent frontal regions, latest complete maturation. Notably, stages were entirely separated values, consistently ages line previous findings adults. Concerning location showing steepest largest shifted posterior anterior regions age. This shift, evident sleep, paralleled migration slow wave was consistent neuroanatomical cognitive development. Overall, distinguishes regardless age; while, reveals postero-anterior Our study could help interpret due pathological conditions may elucidate neurophysiological processes underlying

Language: Английский

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Interindividual aperiodic resting‐state EEG activity predicts cognitive‐control styles

Psychophysiology, Journal Year: 2024, Volume and Issue: 61(8)

Published: March 31, 2024

Abstract The ability to find the right balance between more persistent and flexible cognitive‐control styles is known as “metacontrol.” Recent findings suggest a relevance of aperiodic EEG activity task conditions that are likely elicit specific metacontrol style. Here we investigated whether individual differences in obtained off‐task (during resting state) predict under pose different demands on metacontrol. We analyzed resting‐state data, task‐EEG, behavioral outcomes from sample N = 65 healthy participants performing Go/Nogo task. examined indicator “neural noise” power spectrum, were assigned high‐noise or low‐noise group according median split exponents for state. found predicted Go Nogo conditions: Overall, higher (i.e., noise was lower) group, who however showed no difference trials, whereas exhibited significant reduction persistence‐heavy condition. This suggests trait‐like biases determine default style, which can be overwritten compensated challenging demands. signals represents valid indicators highly dynamic arbitration styles, representing brain's capability reorganize itself adapt its neural patterns changing environmental conditions.

Language: Английский

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Sources of Variation in the Spectral Slope of the Sleep EEG

eNeuro, Journal Year: 2022, Volume and Issue: 9(5), P. ENEURO.0094 - 22.2022

Published: Sept. 1, 2022

Abstract The 1/ f spectral slope of the electroencephalogram (EEG) estimated in γ frequency range has been proposed as an arousal marker that differentiates wake, nonrapid eye movement (NREM) sleep, and rapid (REM) sleep. Here, we sought to replicate extend these findings a large sample, providing comprehensive characterization how changes with age, sex, its test-retest reliability well potential confounds could affect estimation. We used 10,255 whole-night polysomnograms (PSGs) from National Sleep Research Resource (NSRR). All preprocessing steps were performed using open-source Luna package was by fitting log-log linear regression models on absolute power 30 45 Hz separately for NREM, REM stages. confirmed mean grows steeper going wake NREM found choice mastoid referencing scheme modulated extent which electromyogenic, or electrocardiographic artifacts likely bias 30- 45-Hz estimates, other sources technical, device-specific bias. Nonetheless, within individuals, estimates relatively stable over time. Both cross-sectionally longitudinal, slopes tended become shallower increasing particularly sleep; males show flatter than females across all states. Our support can be valuable both clinical research endeavors but also underscore importance considering interindividual variation multiple methodological aspects related

Language: Английский

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Developmental changes in individual alpha frequency: Recording EEG data during public engagement events

Imaging Neuroscience, Journal Year: 2023, Volume and Issue: 1, P. 1 - 14

Published: July 19, 2023

Statistical power in cognitive neuroimaging experiments is often very low. Low sample size can reduce the likelihood of detecting real effects (false negatives) and increase risk non-existing by chance positives). Here, we document our experience leveraging a relatively unexplored method collecting large for simple electroencephalography (EEG) studies: recording EEG community during public engagement outreach events. We collected data from 346 participants (189 females, age range 6-76 years) over 6 days, totalling 29 hours, at local science festivals. Alpha activity (6-15 Hz) was filtered 30 seconds signal, recorded single electrode placed between occipital midline (Oz) inion (Iz) while rested with their eyes closed. A total 289 good-quality datasets were obtained. Using this community-based approach, able to replicate controlled, lab-based findings: individual alpha frequency (IAF) increased childhood, reaching peak 10.28 Hz 28.1 years old, slowed again middle older age. Total decreased linearly, but aperiodic-adjusted did not change lifespan. Aperiodic slopes intercepts highest youngest participants. There no associations these indexes self-reported fatigue, measured Multidimensional Fatigue Inventory. Finally, present set important considerations researchers who wish collect within environments.

Language: Английский

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Early development of electrophysiological activity: Contribution of periodic and aperiodic components of the EEG signal

Psychophysiology, Journal Year: 2023, Volume and Issue: 60(11)

Published: June 15, 2023

Abstract Brain function rapidly changes in the first 2 years of life. In last decades, resting‐state EEG has been widely used to explore those changes. Previous studies have focused on relative power signal established frequency bands (i.e., theta, alpha, and beta). However, is a mixture 1/f‐like background (aperiodic) combination with narrow peaks that appear over curve (periodic activity, e.g., alpha peak). Therefore, it possible captures both, aperiodic periodic brain contributing electrophysiological activity observed infancy. For this reason, we explored early developmental trajectory beta from infancy toddlerhood compared longitudinal study three waves at age 6, 9, 16 18 months. Finally, tested contribution components power. We found trajectories differed period all but alpha. Furthermore, flattened between 6 More importantly, only was exclusively related whereas significantly contributed theta bands. Thus, these frequencies influenced by which should be considered for future studies.

Language: Английский

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Aperiodic components and aperiodic-adjusted alpha-band oscillations in children with ADHD

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 173, P. 225 - 231

Published: March 26, 2024

Language: Английский

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Aperiodic and Hurst EEG exponents across early human brain development: A systematic review

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 68, P. 101402 - 101402

Published: June 7, 2024

In electroencephalographic (EEG) data, power-frequency slope exponents (1/f_β) can provide non-invasive markers of in vivo neural activity excitation-inhibition (E:I) balance. E:I balance may be altered neurodevelopmental conditions; hence, understanding how 1/f β evolves across infancy/childhood has implications for developing early assessments/interventions. This systematic review (PROSPERO-ID: CRD42023363294) explored the maturation (0-26 yrs) resting-state EEG measures (aperiodic [AE], power law [PLE] and Hurst [HE] exponents), including studies containing ≥1 ≥10 typically participants. Five databases (including Embase Scopus) were searched during March 2023. Forty-two identified (Nparticipants=3478). Risk bias was assessed using Quality Assessment with Diverse Studies tool. Narrative synthesis HE data suggests non-stationary occurs throughout development. Age-related trends complex, rapid decreases AEs infancy heterogenous changes thereafter. Regionally, AE maxima shifted developmentally, potentially reflecting spatial maturing brain connectivity. work highlights importance further characterising development to better understand shapes cognitive

Language: Английский

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