Toxic Effects of Glyphosate on the Nervous System: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4605 - 4605

Published: April 21, 2022

Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is the most widely used herbicide in world. It can persist environment for days or months, and its intensive large-scale use constitute major environmental health problem. In this systematic review, we investigate current state of our knowledge related to effects pesticide on nervous system various animal species humans. The information provided indicates that exposure glyphosate commercial formulations induces several neurotoxic effects. has been shown during early stages life seriously affect normal cell development by deregulating some signaling pathways involved process, leading alterations differentiation, neuronal growth, myelination. Glyphosate also seems exert significant toxic effect neurotransmission induce oxidative stress, neuroinflammation mitochondrial dysfunction, processes lead death due autophagy, necrosis, apoptosis, as well appearance behavioral motor disorders. doses produce these vary but are lower than limits set regulatory agencies. Although there important discrepancies between analyzed findings, it unequivocal produces structure function humans, rodents, fish, invertebrates.

Language: Английский

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Revisiting pesticide pollution: The case of fluorinated pesticides

Environmental Pollution, Journal Year: 2021, Volume and Issue: 292, P. 118315 - 118315

Published: Oct. 9, 2021

Language: Английский

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Toxic effects and mechanisms of common pesticides (Roundup and chlorpyrifos) and their mixtures in a zebrafish model (Danio rerio)

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 833, P. 155236 - 155236

Published: April 13, 2022

Language: Английский

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The potential of biochar-based catalysts in advanced treatment technologies for efficacious removal of persistent organic pollutants from wastewater: A review

Process Safety and Environmental Protection, Journal Year: 2022, Volume and Issue: 187, P. 470 - 496

Published: Sept. 14, 2022

Language: Английский

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Occurrence and environmental risk assessment of 22 pesticides in Brazilian freshwaters

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 260, P. 106566 - 106566

Published: May 13, 2023

Language: Английский

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Human health and ecological risk assessment of pesticides from rice production in the Babol Roud River in Northern Iran

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 772, P. 144729 - 144729

Published: Jan. 23, 2021

Language: Английский

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Glyphosate-induced liver and kidney dysfunction, oxidative stress, immunosuppression in Nile tilapia, but ginger showed a protection role

Veterinary Research Communications, Journal Year: 2022, Volume and Issue: 47(2), P. 445 - 455

Published: June 30, 2022

Abstract The water-borne herbicides are involved in the toxicity of aquatic animals resulting impaired health status and low productivity. Dietary medicinal herbs present a practical solution to relieve impacts on performances animals. Herein, we investigated commercial glyphosate-induced oxidative stress, immunosuppression, liver kidney dysfunction, protective role ginger or nanoparticles Nile tilapia. Fish were allocated into four groups: first group presented control without glyphosate feeding, second intoxicated with at 0.6 mg/L fed free diet, third 2.5 g/kg, fourth g/kg. kept under experimental conditions for weeks, samples blood tissues collected after 2 4 weeks. Markedly, fish exposed showed highest ALT AST activities, glucose cortisol levels, malondialdehyde levels (MDA) gills tissues. While had lowest MDA weeks ( P < 0.05). dietary lower than Interestingly, fish-fed urea creatinine higher total protein, albumin, globulin 0.05) similar > Further, GSH, lysozyme activity, immunoglobulin In conclusion, superior standard form enhancing antioxidative immune responses tilapia glyphosate.

Language: Английский

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Novel protective aspects of dietary polyphenols against pesticidal toxicity and its prospective application in rice-fish mode: A Review

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 146, P. 109418 - 109418

Published: Feb. 1, 2024

Language: Английский

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Protective effects of black seed (Nigella sativa) diet supplementation in common carp (Cyprinus carpio) against immune depression, oxidative stress and metabolism dysfunction induced by glyphosate

Fish & Shellfish Immunology, Journal Year: 2020, Volume and Issue: 109, P. 12 - 19

Published: Dec. 4, 2020

Language: Английский

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Assessment of the exposure of two pesticides on common carp (Cyprinus carpio Linnaeus, 1758): Are the prolonged biomarker responses adaptive or destructive?

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2022, Volume and Issue: 261, P. 109446 - 109446

Published: Aug. 24, 2022

Chlorpyrifos (CPF) and cypermethrin (CYP) are two insecticides that have a proven negative effect on non-target aquatic organisms when they enter the surface waters. However, literature comparative effects of these pesticides important aquaculture fish species, such as common carp (Cyprinus carpio Linnaeus, 1758) is not yet scientifically detailed, especially over long-term. The idea conducting long-term exposure to find out how observed biomarkers would change compared short-term exposure. In natural environment, toxicants present alone, but in combination. By monitoring impact individual substances, state ecosystems exposed various could be predicted. Thus, this study aimed evaluate toxicity different concentrations CYP (0.0002, 0.0003, 0.0006 μg/L) CPF (0.03, 0.05, 0.10 50-L glass tanks C. carpio, for 30 days under laboratory conditions. A set histological biochemical gills liver were applied with chemical analyses water organs. Furthermore, condition hepatosomatic index calculated assess physiological status treated carps. behavioral responses also monitored, respiration rate was analyzed. results suggest had more prominent structure organs, anti-oxidant enzymes, behavior, CPF. addition, indicate susceptible chronic chemically induced cellular stress gills, overall destructive changes rather than adaptive. Regardless scenario, our provide novel insights into pesticide possible biological impacts economically freshwater fish, lower concentrations, based EU legislation (maximum allowable MAC-EQS).

Language: Английский

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