Investigation on the pharmacological profile for new synthesized bis heterocyclic analogs containing nitrogen atom as anti-cancer therapy target DOI
Asmaa F. Kassem, Gaber O. Moustafa, Mervat M. Omran

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138450 - 138450

Published: April 30, 2024

Language: Английский

Copper nanoparticles from chemical, physical, and green synthesis to medicinal application: A review DOI Creative Commons
Mehrab Pourmadadi, Roghaieh Holghoomi, Amin Shamsabadipour

et al.

Plant Nano Biology, Journal Year: 2024, Volume and Issue: 8, P. 100070 - 100070

Published: April 16, 2024

This article examines the viability of utilizing plant biomolecules in environmentally sustainable synthesis copper nanoparticles (Cu NPs). By harnessing their intrinsic capabilities reduction and capping, plants present an friendly economically viable substitute for conventional techniques. Through manipulation diverse parameters throughout procedure, scientists are capable attaining Cu NPs desired shapes sizes, thereby customizing them to suit particular applications. review centers on owing its cost-effectiveness comparison other frequently utilized metals such as gold silver. It explores mechanisms that govern NPs. We conduct exhaustive analysis wide-ranging medical healthcare applications, emphasizing capacity fundamentally transform numerous treatment approaches. Furthermore, offers valuable perspectives alternative techniques, facilitating a comparative evaluation enabling well-informed choices be made regarding integration knowledge methods, wide range practical implementations, economic factors, objective this is furnish asset scientists, researchers, practitioners who investigating propel progress.

Language: Английский

Citations

22
Recent advancements in Irinotecan-loaded nanomaterials as a smart drug delivery system for cancer therapy: A state-of-art-review DOI
Sonia Fathi‐karkan,

Maimoona Qindeel,

Rabia Arshad

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 161, P. 112028 - 112028

Published: Jan. 9, 2024

Language: Английский

Citations

11
Innovative chitosan-polyacrylic acid-MoS2 nanocomposite for enhanced and pH-responsive quercetin delivery DOI Creative Commons
Mehrab Pourmadadi, Hamidreza Abdouss,

Amirmohammad Memarzadeh

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 108724 - 108724

Published: March 24, 2024

Cancer remains a global health challenge, with current treatments often leading to adverse side effects. Herein, pH-sensitive, biocompatible nanocomposite composed of chitosan (CS), polyacrylic acid (PAA), and MoS2 nanosheets, loaded quercetin (QCT) as model anticancer drug has been synthesized via the water-oil-water (W/O/W) emulsification method, aim be used for targeted breast cancer treatment. Characterization Fourier-transform infrared spectroscopy (FT-IR) revealed strong interaction between polymers hydrogen bonding, X-ray diffraction (XRD) showed reduction in level crystallinity upon loading. Dynamic light scattering (DLS), zeta potential, field-emission scanning electron microscopy (FE-SEM) tests that nanocarriers were spherical shape had hollow structure, mean size 484 nm high potential +44.3 mV, which confirms their colloidal stability. The addition nanosheets polymeric mixture increased loading encapsulation efficiency 47% 89%, respectively. pH-responsive delivery system, releasing 97% 68% QCT acidic neutral environments, respectively, over 96 hours. biological performance was investigated using MTT flow cytometry assays, confirmed tumor cell removal.

Language: Английский

Citations

11
Advances in erlotinib delivery systems: Addressing challenges and exploring opportunities in EGFR-targeted cancer therapies DOI
Mehrab Pourmadadi, Vahideh Mohammadzadeh, Zahra Mohammadi

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 161, P. 112114 - 112114

Published: Jan. 22, 2024

Language: Английский

Citations

10
Enhancing glioblastoma therapy via intranasal administration of highly potent cell-penetrating peptide decorated nanoparticles DOI

Jain Koo,

Yuseon Shin,

Hyewon Jeon

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 997 - 1012

Published: Jan. 5, 2025

Language: Английский

Citations

1
Emerging innovations in vincristine-encapsulated nanoparticles: Pioneering a new era in oncological therapeutics DOI

Shohreh Bakhshi,

Alireza Shoari, Parisa Alibolandi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 91, P. 105270 - 105270

Published: Dec. 14, 2023

Language: Английский

Citations

21
NPs loaded with zoledronic acid as an advanced tool for cancer therapy DOI
Sonia Fathi‐karkan, Mahira Zeeshan,

Maimoona Qindeel

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 87, P. 104805 - 104805

Published: Aug. 1, 2023

Language: Английский

Citations

20
Harnessing Nanotechnology for Idarubicin Delivery in Cancer Therapy: Current Approaches and Future Perspectives DOI
Fatemeh Safari,

Yeganeh Jalalian,

Hamidreza Abdouss

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4108 - 4130

Published: April 11, 2024

Language: Английский

Citations

7
Combination of Etoposide and quercetin-loaded solid lipid nanoparticles Potentiates apoptotic effects on MDA-MB-231 breast cancer cells DOI Creative Commons
Reza Afarin,

Fatemeh Ahmadpour,

Mahdi Hatami

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31925 - e31925

Published: May 24, 2024

BackgroundBreast cancer is a major global cancer, for which radiation and chemotherapy are the main treatments. Natural remedies being studied to reduce side effects. Etoposide (ETO), chemo-drug, quercetin (QC), phytochemical, considered potential factors adaptation conventional treatments.ObjectivesThe anticancer effect of synergy between ETO Quercetin-loaded solid lipid nanoparticles (QC-SLNs), was investigated in MDA-MB-231 cells.MethodsWe developed QC-SLNs efficient cellular delivery, characterizing their morphology, particle size, zeta potential. We assessed cytotoxicity on breast cells via MTT assay. Effects apoptosis intensity have been detected utilizing annexin V-FITC, PI, caspase activities. Real-time PCR Bax gene Bcl-2 fold change expression, while Western blot analysis determined p53 p21 protein levels.ResultsSpherical, negatively charged QC-SLNs, when combined with ETO, significantly enhanced inhibition cell proliferation compared or alone. The treatment also notably increased pathway. + Bax/Bcl-2 ratio, elevated proteins, activated 3 9 enzymes. These results indicate as strategy treatment, potentially overcoming ETO-resistant chemoresistance.ConclusionThese suggest that QC-SLN has substantial impact cure by improving efficacy ETO. This enhancement could help overcome chemoresistance observed cancer.

Language: Английский

Citations

7
Green Synthesis of pH-Sensitive Carboxymethyl Cellulose/Agarose/Carbon Quantum Dots Nanocarriers for Quercetin Delivery to A549 Lung Cancer Using an Emulsification Method DOI
Mehrab Pourmadadi, Salar Mohammadi Shabestari, Hamidreza Abdouss

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Language: Английский

Citations

6