Deleted Journal,
Journal Year:
2024,
Volume and Issue:
48(6), P. 1397 - 1410
Published: Oct. 8, 2024
One
of
the
promising
strategies
for
destroying
cancer
cells
is
using
small-molecule
gene-silencing
such
as
DNAzyme.
In
current
study,
we
used
niosomes
carriers
to
promote
drug
residence
and
stability
in
human
breast
MCF-7
explore
possible
molecular
mechanisms.
Preparing
was
performed
thin-layer
hydration
method.
Shape
size
were
assessed
transmission
electron
microscopy
(TEM).
Cell
cytotoxicity,
invasion
migration,
apoptosis,
inflammation
apoptosis
related
genes
evaluated
by
MTT
assay,
wound
healing
flow
cytometry,
Real-time
PCR.
Our
results
showed
that
DNAzyme
loaded
had
more
powerful
effects
against
proliferation
migration
compared
free
Effects
attributed
elevation
suppressing
pro-inflammatory
cytokines,
down-regulation
c-Myc/cyclin
D1.
conclusion,
our
study
declares
possess
stronger
on
than
targeting
inflammation,
Journal of Advanced Research in Natural and Applied Sciences,
Journal Year:
2024,
Volume and Issue:
10(1), P. 116 - 133
Published: March 15, 2024
This
study
aimed
to
contribute
revealing
the
health
effects
of
Parthenocissus
quinquefolia
L.
(PQ)
plant
by
examining
biological
activities
various
extracts
plant.
An
ethnobotanical
important
medicinal
plant,
PQ
belongs
Vine
family
(Vitaceae)
and
is
known
for
its
uses.
Herein,
fruit
leaf
alcoholic
exhibited
anticancer
activity
on
triple
negative
breast
cancer
(TNBC)
cell
lines,
estrogen
receptor
positive
(ER+)
(MCF-7),
human
colon
adenocarcinoma
(HT-29)
lines.
Furthermore,
methanol
displayed
strong
radical
scavenging
with
low
IC50
values
such
as
0.51
mg/mL,
0.80
0.84
1.45
mg/mL.
The
highest
TEAC
(18.72
mM
Trolox/mg,
9.90
8.41
Trolox/mg)
were
calculated
red
leaves.
antifungal
was
determined
against
Candida
albicans
fungal
pathogen.
apoptosis
extract
obtained
between
20
µg/mL
70
48
h
72
treatments
Hoechst
33258
staining
nuclei
under
a
fluorescence
microscopy.
HPLC
analysis
performed
determine
major
bioactive
components.
Consequently,
this
may
guide
new
strategies
be
uses
in
applications
further
investigations.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Dec. 30, 2024
Abstract
The
development
of
drug
delivery
systems
has
aimed
to
improve
bioavailability
and
reduce
limitations
traditional
dosing
schedules.
Vesicular
like
niosomes
have
gained
importance
for
their
stability,
cost‐effectiveness,
controlled
release
capabilities.
Niosomes
can
encapsulate
both
hydrophobic
hydrophilic
drugs,
making
them
versatile
carriers
various
therapeutic
agents.
Recent
research
focuses
on
enhancing
targeted
delivery,
such
as
incorporating
4‐hydroxyisoleucine
(4‐HIL)
diabetes
treatment.
In
this
study,
4‐HIL
from
fenugreek
seeds
was
encapsulated
in
PEGylated
using
a
thin‐film
hydration
method.
4‐HIL‐loaded
showed
semi‐spherical,
smooth
structures
with
size
200
nm,
zeta
potential
‐22
mV,
entrapment
efficiency
ranging
55.1%
87.1%.
FTIR
spectroscopy
confirmed
hydrogen
bonding
between
span
60
cholesterol
the
niosomal
formulation.
PEGylation
increased
vesicle
460–580
nm
enhanced
encapsulation
75.43–90.1%.
significantly
suppressed
vitro
4‐HIL,
formulation
promising
system
sustained
anti‐diabetic
drugs.
BIO Web of Conferences,
Journal Year:
2024,
Volume and Issue:
148, P. 01023 - 01023
Published: Jan. 1, 2024
Breast
cancer
is
one
type
of
that
causes
the
most
deaths
in
women.
Currently,
doxorubicin
chemotherapy
treatment
widely
used,
but
due
to
untargeted
side
effects,
a
hydrogel-thermosensitive
preparation
has
been
developed
by
comparing
activity
active
substance
curcumin
with
doxorubicin.
This
systematic
review
aims
determine
development
research
on
anticancer
modified
breast
and
examine
its
looking
at
IC50
value.
The
method
used
searching
for
articles
was
using
Scopus
database
literature
analyzed,
namely
cytotoxic
key
keywords
(“Doxorubicin”
OR
“Curcumin”
AND
“Breast”
“Cancer”
“Therapy”
“
Cytotoxicity”).
inclusion
criteria
were
journals
containing
or
anti-breast
tests
from
publication
years
2020-2024,
full-text
journals.
exclusion
did
not
test
cytotoxicity
MCF-7
cells,
no
value,
regarding
articles,
paid
analysis
results
show
an
value
comparable
mechanism
inducing
apoptosis
cells
activating
caspase
3
9.
So
thermosensitive
hydrogel
provides
opportunity
provided
be
more
targeted.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
48(6), P. 1397 - 1410
Published: Oct. 8, 2024
One
of
the
promising
strategies
for
destroying
cancer
cells
is
using
small-molecule
gene-silencing
such
as
DNAzyme.
In
current
study,
we
used
niosomes
carriers
to
promote
drug
residence
and
stability
in
human
breast
MCF-7
explore
possible
molecular
mechanisms.
Preparing
was
performed
thin-layer
hydration
method.
Shape
size
were
assessed
transmission
electron
microscopy
(TEM).
Cell
cytotoxicity,
invasion
migration,
apoptosis,
inflammation
apoptosis
related
genes
evaluated
by
MTT
assay,
wound
healing
flow
cytometry,
Real-time
PCR.
Our
results
showed
that
DNAzyme
loaded
had
more
powerful
effects
against
proliferation
migration
compared
free
Effects
attributed
elevation
suppressing
pro-inflammatory
cytokines,
down-regulation
c-Myc/cyclin
D1.
conclusion,
our
study
declares
possess
stronger
on
than
targeting
inflammation,
