The Effects of Biomimetic Surface Topography on Vascular Cells: Implications for Vascular Conduits DOI Creative Commons
Abigail A. Conner, Dency David, Evelyn K. F. Yim

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: June 27, 2024

Abstract Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and represent a pressing clinical need. Vascular occlusions predominant CVD necessitate surgical interventions such as bypass graft surgery to replace damaged or obstructed blood vessel with synthetic conduit. Synthetic small‐diameter vascular grafts (sSDVGs) desired vessels an inner diameter <6 mm yet have limited use due unacceptable patency rates. The incorporation biophysical cues topography onto sSDVG biointerface can be used mimic cellular microenvironment improve outcomes. In this review, utility surface in design is discussed. First, primary challenges that sSDVGs face rationale for utilizing biomimetic introduced. current literature surrounding effects topographical on cell behavior vitro reviewed, providing insight into which features optimal application sSDVGs. results studies utilized topographically‐enhanced vivo evaluated. Current barriers translation Based wealth evidence detailed here, substrate offers enormous potential outcome provide therapeutic solutions CVDs.

Language: Английский

Polymer-based responsive structural color materials DOI
Huan Wang, Hui Zhang, Zhuoyue Chen

et al.

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 135, P. 101091 - 101091

Published: Feb. 10, 2023

Language: Английский

Citations

95
Biofabrication methods for reconstructing extracellular matrix mimetics DOI Creative Commons
Abdellah Aazmi, Duo Zhang,

Corrado Mazzaglia

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 475 - 496

Published: Sept. 9, 2023

In the human body, almost all cells interact with extracellular matrices (ECMs), which have tissue and organ-specific compositions architectures. These ECMs not only function as cellular scaffolds, providing structural support, but also play a crucial role in dynamically regulating various functions. This comprehensive review delves into examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical biochemical properties ECMs. We discuss potential integration these ECM-mimics range physiological pathological vitro models, enhancing our understanding behavior organization. Lastly, we propose future research directions for context engineering organ-on-a-chip applications, offering advancements therapeutic approaches improved patient outcomes.

Language: Английский

Citations

59
Multicargo-loaded inverse opal gelatin hydrogel microparticles for promoting bacteria-infected wound healing DOI
Wenhan Li, Haiwen Su, Yanyu Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129557 - 129557

Published: Jan. 17, 2024

Language: Английский

Citations

11
Injectable hydrogels for spinal cord injury repair DOI Creative Commons
Huan Wang, Hui Zhang,

Zhongyu Xie

et al.

Engineered Regeneration, Journal Year: 2022, Volume and Issue: 3(4), P. 407 - 419

Published: Sept. 5, 2022

Spinal cord injury (SCI) often causes severe functional impairment of body, which leads to a huge burden the patient and whole society. Many strategies, especially biomaterials, have been employed for SCI repair. Among various injectable hydrogels attracted much attention because their ability load components be injected into lesioned area without surgeries. In this review, we summarize recent progress in We firstly introduce pathophysiology SCI, reveals mechanism clinical manifestations determines therapeutic schedule. Then, describe original sources polymers crosslinking manners forming hydrogels. After that, focus on vivo strategies effects Finally, challenges future outlook hydrogel repair are concluded discussed. believe review can helpful inspire further development

Language: Английский

Citations

36
Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing DOI Creative Commons
Ryan P. Trueman, Owein Guillemot‐Legris, Henry T. Lancashire

et al.

Advanced Engineering Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 25, 2024

Electrical stimulation has shown promise in clinical studies to treat nerve injuries. This work is aimed create an aligned bioelectronic construct that can be used bridge a gap, directly interfacing with the damaged tissue provide growth support. The conductive three-dimensional scaffolds described herein are composite materials, comprised of polypyrrole (PPy) nanoparticles embedded collagen hydrogel. constructs seeded dorsal root ganglion derived primary rat neurons and electrically stimulated vitro. PPy loaded support 1.7-fold increase neurite length comparison control constructs. Furthermore, upon electrical PPy-collagen construct, 1.8-fold shown. illustrates potential neural engineering lays groundwork for development novel materials applications.

Language: Английский

Citations

7
Natural Materials for 3D Printing and Their Applications DOI Creative Commons
Chunyu Su, Yutong Chen,

Shujing Tian

et al.

Gels, Journal Year: 2022, Volume and Issue: 8(11), P. 748 - 748

Published: Nov. 17, 2022

In recent years, 3D printing has gradually become a well-known new topic and research hotspot. At the same time, advent of is inseparable from preparation bio-ink. Natural materials have advantages low toxicity or even non-toxicity, there being abundant raw materials, easy processing modification, excellent mechanical properties, good biocompatibility, high cell activity, making them very suitable for With help technology, prepared scaffolds can be widely used in tissue engineering other fields. Firstly, we introduce natural their properties summarize physical chemical these applications after modification. Secondly, discuss modification methods including physical, chemical, protein self-assembly methods. We also method printing. Then, application engineering, skin tissue, cartilage bone vascular tissue. Finally, express some views on materials.

Language: Английский

Citations

28
Novel Scaffold Based on Chitosan Hydrogels/Phthalated Cashew Gum for Supporting Human Dental Pulp Stem Cells DOI Creative Commons
Yulla Klinger de Carvalho Leite, Antônia Carla de Jesus Oliveira, Patrick Veras Quelemes

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 266 - 266

Published: Feb. 10, 2023

Hydrogels are structures that have value for application in the area of tissue engineering because they mimic extracellular matrix. Naturally obtained polysaccharides, such as chitosan (CH) and cashew gum, materials with ability to form polymeric networks due their physicochemical properties. This research aimed develop a scaffold based on phthalated tree gum test it support growth human mesenchymal stem cells. In this study, phthalation (PCG) was performed by using solvent-free route. PCG-CH developed polyelectrolyte complexation, its adherent cell evaluated. The showed high swelling rate. pore sizes were analyzed scanning electron microscopy. Human dental pulp cells (hDPSCs) isolated, expanded, characterized potential differentiate into lineages immunophenotypic profile. Isolated presented fibroblastoid morphology, plastic adhesion capacity, differentiation osteogenic, adipogenic, chondrogenic lineages. Mesenchymal cultured scaffolds assess growth. seeded typical attachment, adequate distribution inside matrix pores. Thus, may improve osteoinductive osteoconductive properties these biomaterials.

Language: Английский

Citations

12
Design of gefitinib-loaded PLGA microspheres via microfluidics for lung cancer DOI Creative Commons

Ruohan Huang,

Hui Zhang,

Lulu Lv

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 234, P. 112336 - 112336

Published: Sept. 19, 2023

Lung cancer is one of the most prevalent tumors with rapid progression and poor prognosis, which badly affects human physical mental health. Although traditional anti-cancer therapies, such as chemotherapy radiation, have demonstrated some degree effectiveness in treating tumors, they remain encumbered by frequent, uncontrollable, large dosage drug administration. Here, we introduced Gefitinib-loaded PLGA microspheres generated from microfluidics for lung therapy. The had a homogeneous shape high loading rate. Studies shown that not only provided greater efficiency sustained release gefitinib but also protected breakdown. results animal experiments showed drug-loaded could achieve or even outperform daily medication less frequency. Therefore, it foreseen will great potential developing therapies cancer.

Language: Английский

Citations

12
Celastrol-encapsulated microspheres prepared by microfluidic electrospray for alleviating inflammatory pain DOI

Huiyu Zheng,

Cheng Zhao, Yitian Lu

et al.

Biomaterials Advances, Journal Year: 2023, Volume and Issue: 149, P. 213398 - 213398

Published: March 21, 2023

Language: Английский

Citations

11
Bioprinting: Mechanical Stabilization and Reinforcement Strategies in Regenerative Medicine DOI

Ashleigh Ballard,

Rebecca Patush,

Jenesis Perez

et al.

Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: 30(13-14), P. 387 - 408

Published: Jan. 11, 2024

Bioprinting describes the printing of biomaterials and cell-laden or cell-free hydrogels with various combinations embedded bioactive molecules. It encompasses precise patterning cells to create scaffolds for different biomedical needs. There are many requirements that bioprinting face, it is ultimately interplay between scaffold's structure, properties, processing, performance will lead its successful translation. Among essential properties must possess—adequate appropriate application-specific chemical, mechanical, biological performance—the mechanical behavior hydrogel-based bioprinted key their stable in vivo at site implantation. Hydrogels typically constitute main scaffold material medium biomolecules very soft, often lack sufficient stability, which reduces printability and, therefore, potential. The aim this review article highlight reinforcement strategies used approaches achieve enhanced stability bioinks printed scaffolds. Enabling robust materials processes creation truly complex remarkable structures could accelerate application smart, functional settings. a powerful tool fabrication 3D applications. has gained tremendous attention recent years, bioink library expanding include more combinations. From practical perspective, need be considered, such as structure's performances. these, constructs critical translation into clinic. explore stabilization structures.

Language: Английский

Citations

4