The size-dependence and reversibility of polystyrene nanoplastics-induced hepatic pyroptosis in mice through TXNIP/NLRP3/GSDMD pathway DOI

Yanyang Lu,

Weizhen Hua,

Lu Lu

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(4)

Published: July 1, 2024

As emerging environmental contaminants, nanoplastics (NPs) are progressively accumulating in terrestrial and aquatic ecosystems worldwide, posing a potential threat to human health. The liver is considered as one of the primary organs targeted by NPs accumulation living organisms. However, there remains large knowledge gap concerning NPs-induced hepatotoxicity. In this study, we examined impact chronic exposure environmentally relevant doses polystyrene (PS) on hepatic pyroptosis mice. results demonstrated that both particle sizes PS-NPs (100 nm 500 nm) significantly triggered mouse liver, evidenced upregulation GSDMD-N protein levels; moreover, pyroptotic effect induced 100 was more pronounced compared PS-NPs. Mechanistically, resulted an TXNIP expression, thereby activating NLRP3 inflammasome subsequently inducing inflammatory responses pyroptosis. Notably, following termination subsequent recovery period 50 days, PS-NPs-mediated inflammation via TXNIP/NLRP3 pathway were effectively ameliorated, even returning levels close baseline. Collectively, our findings provide novel evidence for size-dependence reversibility through TXNIP/NLRP3/GSDMD vivo.

Language: Английский

A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo DOI Creative Commons
Narmin Bashirova, David Poppitz, Nils Klüver

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 2, 2023

Plastic pollution, especially by nanoplastics (NPs), has become an emerging topic due to the widespread existence and accumulation in environment. The research on bioaccumulation toxicity mechanism of NPs from polyethylene terephthalate (PET), which is widely used for packaging material, have been poorly investigated. Herein, we report first use high-resolution magic-angle spinning (HRMAS) NMR based metabolomics combination with assay behavioural end points get systems-level understanding PET intact zebrafish embryos. exhibited significant alterations hatching survival rate. Accumulation larvae were observed liver, intestine, kidney, coincide localization reactive oxygen species these areas. HRMAS data reveal that cause: (1) alteration metabolites related targeting liver pathways associated detoxification oxidative stress; (2) impairment mitochondrial membrane integrity as reflected elevated levels polar head groups phospholipids; (3) cellular bioenergetics evidenced changes numerous interrelated energy metabolism. Taken together, this work provides time a comprehensive system level exposure larvae.

Language: Английский

Citations

47
Negative impacts of nanoplastics on the purification function of submerged plants in constructed wetlands: Responses of oxidative stress and metabolic processes DOI
Yang Liu,

Lichao Wei,

Hongwei Yu

et al.

Water Research, Journal Year: 2022, Volume and Issue: 227, P. 119339 - 119339

Published: Nov. 8, 2022

Language: Английский

Citations

53
Trade-off of abiotic stress response in floating macrophytes as affected by nanoplastic enrichment DOI

Huawei Jia,

Hongwei Yu, Jingwen Li

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 451, P. 131140 - 131140

Published: March 4, 2023

Language: Английский

Citations

32
Nanoplastics Toxicity Specific to Liver in Inducing Metabolic Dysfunction—A Comprehensive Review DOI Open Access
Shoumi Haldar,

Nounenuo Yhome,

Yuvashree Muralidaran

et al.

Genes, Journal Year: 2023, Volume and Issue: 14(3), P. 590 - 590

Published: Feb. 26, 2023

Plastic pollution in the world is widespread and growing. The environment swamped with nanoplastics (<100 nm), health consequences of these less visible pollutants are unknown. Furthermore, there evidence that microplastics can release by digestive disintegration, implying macroplastic exposure cause direct indirect disease via nanoplastics. existence impact numerous tissues from invertebrates to larger vertebrates consume significant amounts plastics were investigated, histopathological techniques utilized determine physiological reactions inflammation plastics. Nanoplastics enters an organism through respiratory gastro-intestinal tract where they accumulate into liver blood circulation absorption, or epidermal infiltration. It stated macroplastics damage directly at site exposure, whereas influence liver, causing subsequent other organs. Multi-organ dysfunction brought on changes, readily enter gut-liver axis disturb gut microflora. By exploring literature summarizing research has been published date, this review article reveals deleterious effect mechanisms pathophysiological functions hepatic system.

Language: Английский

Citations

30
Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution DOI Open Access
Arianna Dolce, Sara Della Torre

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2335 - 2335

Published: May 16, 2023

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic and represents an increasing public health issue given limited treatment options its association with several other metabolic inflammatory disorders. The epidemic, still growing prevalence NAFLD worldwide cannot be merely explained by changes in diet lifestyle that occurred last few decades, nor from their genetic epigenetic risk factors. It conceivable environmental pollutants, which act as endocrine disruptors, may contribute to spreading this pathology due ability enter food chain ingested through contaminated water. Given strict interplay between nutrients regulation hepatic metabolism reproductive functions females, pollutant-induced dysfunctions particular relevance for female liver, dampening sex differences prevalence. Dietary intake pollutants can particularly detrimental during gestation, when endocrine-disrupting chemicals interfere programming metabolism, accounting developmental origin offspring. This review summarizes cause-effect evidence increased incidence emphasizes need further studies field.

Language: Английский

Citations

27
Toxic effects and mechanisms of nanoplastics on embryonic brain development using brain organoids model DOI Open Access
Shiqun Chen, Yue Chen,

Yifei Gao

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 904, P. 166913 - 166913

Published: Sept. 7, 2023

Language: Английский

Citations

26
Cellular and bioenergetic effects of polystyrene microplastic in function of cell type, differentiation status and post-exposure time DOI
Miao Peng, Maaike Vercauteren, Charlotte Grootaert

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 337, P. 122550 - 122550

Published: Sept. 15, 2023

Language: Английский

Citations

23
Nanoplastic contamination: Impact on zebrafish liver metabolism and implications for aquatic environmental health DOI Creative Commons
Abdul Rehman, Fu-Yi Huang, Zixing Zhang

et al.

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108713 - 108713

Published: May 1, 2024

Nanoplastics (NPs) are increasingly pervasive in the environment, raising concerns about their potential health implications, particularly within aquatic ecosystems. This study investigated impact of polystyrene nanoparticles (PSN) on zebrafish liver metabolism using liquid chromatography hybrid quadrupole time flight mass spectrometry (LC-QTOF-MS) based non-targeted metabolomics. Zebrafish were exposed to 50 nm PSN for 28 days at low (L-PSN) and high (H-PSN) concentrations (0.1 10 mg/L, respectively) via water. The results revealed significant alterations key metabolic pathways exposure groups. metabolites showed different responses with L-PSN H-PSN. A total 2078 metabolite features identified from raw data obtained both positive negative ion modes, 190 deemed statistically H-PSN Disruptions lipid metabolism, inflammation, oxidative stress, DNA damage, amino acid synthesis identified. Notably, induced changes building blocks, membrane-associated biomarkers, immune-related metabolites, while was associated altered antioxidant injury. For first time, found depolymerized by cytochrome P450 enzymes. Utilizing an analytical approach adverse outcome pathway (AOP), impaired stress have been as potentially conserved events (KEs) exposure. These KEs further steatosis, fibrosis tissue organ level. Ultimately, this could significantly biological health. highlights PSN-induced effects emphasizing need a better understanding risks NPs contamination

Language: Английский

Citations

13
Maternal exposure to polystyrene nanoplastics causes defective retinal development and function in progeny mice by disturbing metabolic profiles DOI
Shiyi Xiong, Jincan He, Hao Qiu

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 352, P. 141513 - 141513

Published: Feb. 20, 2024

Language: Английский

Citations

12
Mitochondria as a Target of Micro- and Nanoplastic Toxicity DOI Creative Commons
Fulya Dal, Müfide Aydoğan Ahbab

Cambridge Prisms Plastics, Journal Year: 2024, Volume and Issue: 2

Published: Jan. 1, 2024

Abstract Mitochondria are unique organelles to perform critical functions such as energy production, lipid oxidation, calcium homeostasis, and steroid hormone synthesis in eukaryotic cells. The proper functioning of mitochondria is crucial for cellular survival, bioenergetics. Mitochondrial structure function maintained by the mitochondrial quality control system, which consists processes biogenesis, dynamics (fusion/fission), mitophagy, unfolded protein response UPR MT . dysfunction and/or damage associated with initiation progression several human diseases, including neurodegenerative, cardiovascular, age-related diabetes, cancer. Environmental stress contaminants may exacerbate sensitivity causes dysfunction. There growing evidence about impact nanoplastics (NPs) microplastics (MPs) on health function. MPs/NPs were reported trigger oxidative reactive oxygen species eventually change membrane potential. can cross through biological barriers body be internalized cells, potentially altering dynamics, bioenergetics, signaling pathways, thus impacting metabolism This review states effects homeostasis well apoptosis discussed.

Language: Английский

Citations

12