THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Journal Year: 2024, Volume and Issue: 28(3), P. 42 - 60

Published: Dec. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Language: Английский

Microplastic and plastic pollution: impact on respiratory disease and health DOI Creative Commons
Gwenda F. Vasse, Barbro N. Melgert

European Respiratory Review, Journal Year: 2024, Volume and Issue: 33(172), P. 230226 - 230226

Published: April 30, 2024

Throughout their lifecycle, from production to use and upon disposal, plastics release chemicals particles known as micro- nanoplastics (MNPs) that can accumulate in the environment. MNPs have been detected different locations of human body, including our lungs. This is likely a consequence MNP exposure through air we breathe. Yet, still lack comprehensive understanding impact may on respiratory disease health. In this review, collated current body evidence implications inhalation lung health vitro , vivo occupational studies. We focused interactions between pollution specific lung-resident cells diseases. conclude it evident possess capacity affect tissue remains unclear which extent occurs ambient levels MNPs, emphasising need for more evaluation environmental everyday life.

Language: Английский

Citations

27
The micro(nano)plastics perspective: exploring cancer development and therapy DOI Creative Commons
Xiangying Deng,

Yajun Gui,

Lin Zhao

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

Citations

2
Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence DOI Creative Commons

Faiza Mahmud,

Drishty B. Sarker,

Jonathan A. Jocelyn

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1788 - 1788

Published: Oct. 29, 2024

Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, increasing industrial production have led to questions about their long-term impact on human animal health. This narrative review describes the effects of MNPs oxidative stress, inflammation, aging. Exposure leads increased reactive oxygen species (ROS) across multiple experimental models, including cell lines, organoids, systems. ROS can cause damage cellular macromolecules such as DNA, proteins, lipids. Direct interaction between immune cells or an indirect result stress-mediated may lead pro-inflammatory cytokines throughout different MNP-exposure conditions. inflammatory response is a common feature in pathogenesis neurodegenerative, cardiovascular, other age-related diseases. also act senescence inducers by promoting mitochondrial dysfunction, impairing autophagy, activating DNA responses, exacerbating aging altogether. Increased reproductive transfer MNPs/induced damages from parents offspring animals further corroborates transgenerational health risks tiny particles. aims provoke deeper investigation into notorious these pervasive particles well-being longevity.

Language: Английский

Citations

11
A review on advancements in atmospheric microplastics research: The pivotal role of machine learning DOI

Jiaer Yang,

Zezhi Peng,

Jian Sun

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 945, P. 173966 - 173966

Published: June 17, 2024

Language: Английский

Citations

10
Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress: In vivo and liver organoids-based in vitro study DOI Creative Commons
Wei Cheng,

Hange Chen,

Yue Zhou

et al.

Environment International, Journal Year: 2024, Volume and Issue: 191, P. 108949 - 108949

Published: Aug. 15, 2024

Ageing is a nature process of microplastics that occurrs daily, and human beings are inevitably exposed to aged microplastics. However, systematic understanding ageing status its toxic effect currently still lacking. In this study, plastic cup lids-originated polypropylene (PP) were UV-photoaged until the carbonyl index (CI), canonical indicator for ageing, achieved 0.08, 0.17, 0.22 0.28. The adverse hepatic these PPs (aPPs) was evaluated in Balb/c mice (75 ng/mL water, about 200 particles/day) human-originated liver organoids (LOs, 50 particles/mL, ranged from 5.94 13.15 ng/mL) at low-dose equivalent exposure level. Low-dose PP could induce reductive stress both vitro vivo, by elevating NADH/NAD+ratio CI-dependent manner, together with hepatoxicity (indicated increased AST secretion cytotoxicity), disrupted genes encoding nutrients transporters NADH subunits accompanied restricted ATP supply, declined mitochondrial membrane potential complexI/IV activities, without significant increase MDA levels liver. These changes metabolism, representing circulatory panel increases lactate, triglyceride, Fgf21 levels, decreases pyruvate level, linked body weight gain but elevated contents following aPPs exposure. Additionally, assessing LOs, it found digestion drastically accelerated worsen energy supply upon mitochondria, "scattergun effect" induced formation micro- nano-plastics mixture toward NADH/NAD+imbalance.

Language: Английский

Citations

6
Investigation of Cell-to-cell Transfer of Polystyrene Microplastics Through Extracellular Vesicle-mediated Communication. DOI
Nara Kim, Joo Hyun Park, Inha Lee

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150719 - 150719

Published: Sept. 24, 2024

Language: Английский

Citations

4
Microplastics and potential damage to human cells DOI
R. H. Waring,

Stephen C. Mitchell

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 405 - 416

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enhancing food safety and cultivated meat production: exploring the impact of microplastics on fish muscle cell proliferation and differentiation DOI Creative Commons
Taozhu Sun, Alfonso Timoneda,

Amiti Banavar

et al.

Frontiers in Food Science and Technology, Journal Year: 2024, Volume and Issue: 4

Published: Feb. 28, 2024

Cultivated meat, a sustainable alternative to traditional livestock farming, has gained attention for its potential environmental and health benefits. However, concerns about microplastic contamination pose challenges, especially when sourcing cells from marine organisms prone bioaccumulation. Additionally, the pervasive presence of microplastics in laboratory settings, ingredients, during production, increases risk unintentional contamination. This study focused on Atlantic mackerel ( Scomber scombrus ) skeletal muscle cell lines examine effects exposure, represented by fluorescent polyethylene microspheres (10–45 µm) performance including proliferation, viability, gene expression, differentiation processes critical cultivated meat production. The results revealed significant impacts attachment proliferation at concentrations 1 μg/mL, 10 50 μg/mL. Notably, μg/mL concentration exerted most pronounced viability both phases. While indicated that size influence remained unaffected, additional contributing factors require further investigation. These findings underscore necessity thoroughly exploring microplastic-cell interactions ensure food safety safeguard within burgeoning industry.

Language: Английский

Citations

3
Probing Long-Term Impacts: Low-Dose Polystyrene Nanoplastics Exacerbate Mitochondrial Health and Evoke Secondary Glycolysis via Repeated and Single Dosing DOI
Miao Peng, Charlotte Grootaert, Maaike Vercauteren

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(23), P. 9967 - 9979

Published: May 30, 2024

Nanoplastics (NPs) are omnipresent in the environment and contribute to human exposure. However, little is known regarding long-term effects of NPs on health. In this study, intestinal Caco-2 cells were exposed polystyrene nanoplastics (nanoPS) an environmentally relevant concentration range (102–109 particles/mL) under two realistic exposure scenarios. first scenario, repeatedly nanoPS every 2 days for 12 study effects. second only was added once cultured duration initial NPs. Under repeated dosing, subtle mitochondria induced by low concentrations would accrue over consistent finally lead significant impairment mitochondrial respiration, mass, cell differentiation process at end prolonged exposure, accompanied significantly increased glycolysis whole period. Single dosing elicited transient glycolytic functions, as well reactive oxygen species (ROS) production early phase but self-recovery capacity mitigated these intermediate culture times. Notably, secondary ROS observed during late period, while mass not affected end. These crucial importance comprehensively evaluating health hazards arising from lifetime NPs, complementing extensively acute associated with prevalent short-term high concentrations. Our underlines need toxicity scenarios such dosing.

Language: Английский

Citations

3
The Potential Mechanisms Involved in the Disruption of Spermatogenesis in Mice by Nanoplastics and Microplastics DOI Creative Commons

Yixian Wen,

Jing Cai, Huilian Zhang

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1714 - 1714

Published: Aug. 1, 2024

Plastic-based products are ubiquitous due to their tremendous utility in our daily lives. Nanoplastic (NP) and microplastic (MP) pollution has become a severe threat the planet is growing concern. It been widely reported that polystyrene (PS) MPs severely toxic male reproduction system, with effects including decreased sperm parameters, impaired spermatogenesis, damaged testicular structures. However, molecular mechanisms for spermatogenesis remain poorly understood.

Language: Английский

Citations

3