Expanding the insight of ecological risk on the novel chiral pesticide mefentrifluconazole: Mechanism of enantioselective toxicity to earthworms (Eisenia fetida)

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 466, P. 133585 - 133585

Published: Jan. 22, 2024

Language: Английский

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Enantioselective Degradation and Bioactivity Mechanism of a New Chiral Fungicide Fluindapyr in Paddy Ecosystems

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(3), P. 1426 - 1433

Published: Jan. 11, 2023

Fluindapyr is a novel chiral succinate dehydrogenase inhibitor used to control fungal diseases. The enantioselective effects of fluindapyr in paddy ecosystems are unknown. We developed new determination method using ultrahigh performance liquid chromatography tandem mass spectrometry. absolute configuration the enantiomers was identified by an electron circular dichroism model. A husk-based biochar material optimize and establish QuEchERs for soil determination. Under anaerobic conditions, half-lives R-fluindapyr S-fluindapyr were 69.6 101.8 days, respectively. degraded more rapidly than S-fluindapyr. 87.8 times active against Rhizoctonia solani R-fluindapyr. bioactivity mechanism illustrated molecular docking between SDH R. solani. binding powers proteins -32.12 - 42.91 kcal/mol, This study reports stereoselectivity about determination, degradation, bioactivity, its mechanism. It provides foundation in-depth at enantiomer level.

Language: Английский

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Stereoselective bioaccumulation and degradation of chiral pesticide hexythiazox in earthworm-soil microcosm

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 273, P. 116148 - 116148

Published: Feb. 28, 2024

The chiral pesticide hexythiazox was extensively employed in agricultural activities and has garnered growing concern for its harmful impact on the ecosystem. This study investigates toxicodynamic earthworm at enantiomeric level of hexythiazox. Earthworms exhibited notable enantioselectivity during accumulation stage. Furthermore, presence earthworms can rate degradation soil. two enantiomers adhered to one-compartment model, whereas elimination phase governed by first-order kinetics equation. it discovered that there no observed phase.

Language: Английский

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Enantioselectivity in ecotoxicity of pharmaceuticals, illicit drugs, and industrial persistent pollutants in aquatic and terrestrial environments: A review

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169573 - 169573

Published: Dec. 25, 2023

At present, there is a serious concern about the alarming number of recalcitrant contaminants that can negatively affect biodiversity threatening ecological status marine, estuarine, freshwater, and terrestrial ecosystems (e.g., agricultural soils forests). Contaminants emerging (CEC) such as pharmaceuticals (PHAR), illicit drugs (ID), industrial persistent pollutants, polychlorinated biphenyls (PCBs) polybrominated diphenyl ethers (PBDEs) chiral ionic solvents are globally spread potentially toxic to non-target organisms. More than half these have been measured at different enantiomeric proportions in diverse ecosystems. Enantiomers exhibit toxicodynamics toxicokinetics, thus, cause effects. Therefore, distribution occurrence cannot be neglected toxicity other adverse biological effects expected enantioselective. Hence, this review aims reinforce recognition stereochemistry environmental risk assessment (ERA) CEC gather up-to-date information current knowledge regarding enantioselectivity ecotoxicity PHAR, ID, pollutants (PCBs PBDEs) present freshwater soil We performed an online literature search obtain state-of-the-art research enantioselective studies available for assessing impact classes CEC. Ecotoxicity assays carried out using organisms belonging trophic levels microorganisms, plants, invertebrates, vertebrates, considering ecologically relevant aquatic species or models recommended by regulatory entities. A battery was also reported encompassing standard acute sub-chronic chronic endpoints biomarkers biochemical, morphological alterations, reproduction, behavior, etc.). Nevertheless, we call attention lack potential many several compounds. Additionally, questions key species, selection most appropriate toxicological ERA addressed critically discussed.

Language: Английский

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Systemic evaluation of novel acaricide hexythiazox for bioactivity improvement and risk reduction at the enantiomer level

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 171907 - 171907

Published: March 22, 2024

Language: Английский

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Enantioselective bioaccumulation, biotransformation and spatial distribution of chiral fungicide difenoconazole in earthworms (Eisenia fetida)

Chemosphere, Journal Year: 2024, Volume and Issue: 361, P. 142404 - 142404

Published: May 21, 2024

Language: Английский

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Absorption, distribution, metabolism, and elimination of epoxiconazole enantiomers in lizards (Eremias argus)

Chemosphere, Journal Year: 2024, Volume and Issue: 360, P. 142444 - 142444

Published: May 24, 2024

Language: Английский

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Stereoselective accumulation and biotransformation of chiral fungicide epoxiconazole and oxidative stress, detoxification, and endogenous metabolic disturbance in earthworm (Eisenia foetida)

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 858, P. 159932 - 159932

Published: Nov. 5, 2022

Language: Английский

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Systematic health risks assessment of chiral fungicide famoxadone: Stereoselectivities in ferroptosis-mediated cytotoxicity and metabolic behavior

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135199 - 135199

Published: July 14, 2024

Language: Английский

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Stereoselective toxicity: Investigating the adverse effects of benzovindiflupyr on Xenopus laevis tadpoles

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: unknown, P. 135789 - 135789

Published: Sept. 1, 2024

Language: Английский

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