Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney DOI Creative Commons
Hui Zou, Song Jie, Xiang‐Qian Luo

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104490 - 104490

Published: Nov. 12, 2024

Polyvinyl chloride microplastics (PVC-MPs) and Cadmium (Cd) are widely occurring water pollutants that interact with each other to exert toxic effects. As a waterfowl, Muscovy duck is more susceptible PVC-MPs Cd than land poultry. In this study, was used as research model, 10 mg/L 50 mg/kg were alone in combine explore the effect on kidney of duck. We found treatment or changed weight, increased creatinine urea nitrogen content, disrupted oxidative balance macro/trace element metabolism, while combination PVC-MPs+Cd reduced accumulation kidney. addition, caused mitochondrial damage, increase decrease mitochondria-associated proteins (Fis1, Drp1, PGC-1α, Nrf1), Nrf2 signaling pathway plays key role detoxification alleviation stress, we recovered related (Nrf2, Keap-1, HO-1, NQO1, AC-SOD

Language: Английский

Polyvinyl chloride (PVC), its additives, microplastic and human health: Unresolved and emerging issues DOI

Luca Campisi,

Concettina La Motta,

Dorota Napierska

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178276 - 178276

Published: Jan. 1, 2025

Language: Английский

Citations

2
Micro-nanoplastics and cardiovascular diseases: evidence and perspectives DOI Creative Commons
Francesco Prattichizzo, Antonio Ceriello, Valeria Pellegrini

et al.

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(38), P. 4099 - 4110

Published: Sept. 6, 2024

Abstract Emerging evidence indicates that chemical exposures in the environment are overlooked drivers of cardiovascular diseases (CVD). Recent suggests micro- and nanoplastic (MNP) particles derived largely from or mechanical degradation plastics might represent a novel CVD risk factor. Experimental data preclinical models suggest MNPs can foster oxidative stress, platelet aggregation, cell senescence, inflammatory responses endothelial immune cells while promoting range metabolic alterations lead to disease premature death. In humans, various plastics, including polyethylene polyvinylchloride, have been detected atherosclerotic plaques other tissues, pericardia, epicardial adipose pericardial myocardia, left atrial appendages. measurable levels within thrombi seem accumulate preferentially areas vascular lesions. Their presence carotid is associated with subsequent increased incidence events. To further investigate possible causal role CVD, future studies should focus on large, prospective cohorts assessing exposure individuals plastic-related pollution, routes absorption, existence putative safety limit, correspondence between accumulation timing development, pathophysiological mechanisms instigated by pertinent concentrations MNPs. Data such would allow design preventive, even therapeutic, strategies. Meanwhile, existing reducing plastic production use will produce benefits for human health. This goal could be achieved through UN Global Plastics Treaty currently negotiation.

Language: Английский

Citations

12
Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms DOI
Naveen Kumar,

Mridul Lamba,

Ashok Kumar Pachar

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3109 - 3121

Published: July 20, 2024

Language: Английский

Citations

11
Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence DOI Creative Commons

Faiza Mahmud,

Drishty B. Sarker,

Jonathan A. Jocelyn

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1788 - 1788

Published: Oct. 29, 2024

Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, increasing industrial production have led to questions about their long-term impact on human animal health. This narrative review describes the effects of MNPs oxidative stress, inflammation, aging. Exposure leads increased reactive oxygen species (ROS) across multiple experimental models, including cell lines, organoids, systems. ROS can cause damage cellular macromolecules such as DNA, proteins, lipids. Direct interaction between immune cells or an indirect result stress-mediated may lead pro-inflammatory cytokines throughout different MNP-exposure conditions. inflammatory response is a common feature in pathogenesis neurodegenerative, cardiovascular, other age-related diseases. also act senescence inducers by promoting mitochondrial dysfunction, impairing autophagy, activating DNA responses, exacerbating aging altogether. Increased reproductive transfer MNPs/induced damages from parents offspring animals further corroborates transgenerational health risks tiny particles. aims provoke deeper investigation into notorious these pervasive particles well-being longevity.

Language: Английский

Citations

11
A review on advancements in atmospheric microplastics research: The pivotal role of machine learning DOI

Jiaer Yang,

Zezhi Peng,

Jian Sun

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 945, P. 173966 - 173966

Published: June 17, 2024

Language: Английский

Citations

9
A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis DOI
R. K. Gautam,

Laltanpuia,

Nishant Singh

et al.

Inhalation Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 11, 2025

In the past decade, microplastics (MPs) have drawn significant attention as widespread environmental contaminants, with research increasingly highlighting their harmful effects on respiratory health in aquatic and terrestrial organisms. Findings revealed human lung tissues, raising concerns about potential role damaging tissue integrity contributing to pulmonary fibrosis-a chronic inflammatory condition characterized by scarring of epithelial tissues due accumulated extracellular matrix, triggered factors such alcohol, pathogens, genetic mutations, pollutants. this review, we explore both well-studied lesser-studied mechanisms signaling pathways, aiming shed light how might act mediators that activate distinct, often overlooked cascades. This review searched PubMed Google Scholar using keywords like "plastic," "microplastic," "lung fibrosis," "pulmonary system," "exposure route," "signaling pathways," combined "OR" "AND" singular plural forms. These pathways could not only induce damage but also play a development fibrosis. be targeted reduce microplastic-induced fibrosis, opening new avenues for future treatments.

Language: Английский

Citations

1
Raman-guided exploration of placental microplastic exposure: Unraveling the polymeric tapestry and assessing developmental implications DOI
Yun Xiang, Liyang Liang, Jiaqi Tian

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135271 - 135271

Published: July 20, 2024

Language: Английский

Citations

6
Micro(nano)plastics: an Emerging Burden for Human Health DOI Creative Commons

Isabella Donisi,

Antonino Colloca,

Camilla Anastasio

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(14), P. 5779 - 5792

Published: Oct. 21, 2024

The escalation of plastic pollution represents a global environmental and health problem. Important toxic effects have been attributed to the increasing diffusion microplastics (MPs) nanoplastics (NPs) derived from degradation plastics. These particles ubiquitously observed in environment, with humans being continuously exposed via ingestion, inhalation skin contact. Nonetheless, cellular homeostasis imbalance induced by micro- nano- plastics (MNPs) human has only recently shown, while most evidence molecular mechanisms studies

Language: Английский

Citations

5
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors DOI Creative Commons
Michelangela Barbieri, Francesco Prattichizzo, Rosalba La Grotta

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102405 - 102405

Published: July 4, 2024

Diabetes mellitus, a metabolic condition affecting around 537 million individuals worldwide, poses significant challenges, particularly among the elderly population. The etiopathogenesis of type 2 diabetes (T2D) depends on combination effects driven by advancing age, genetic background, and lifestyle habits, e.g. overnutrition. These factors influence development T2D differently in men women, with an obvious sexual dimorphism possibly underlying diverse clinical features disease different sexes. More recently, environmental pollution, estimated to cause 9 deaths every year, is emerging as novel risk factor for T2D. Indeed, exposure atmospheric pollutants such PM2.5, O3, NO2, Persistent Organic Pollutants (POP)s, along their bioaccumulation, associated obesity, 15 % excess case very high levels PM2.5. Similar data are available plasticizer molecules, bisphenol A phthalates, endocrine-disrupting chemicals. Even though causality still debated at this stage, preclinical evidence sustains ability multiple affect pancreatic function, promote insulin resistance, alter lipid metabolism, contributing onset progression. In addition, findings suggest possible role also plastic itself pioneeristic studies evidenced that micro- or nanoplastics (MNP)s, particles nano- range, cellular damage, senescence, inflammation, disturbances, leading resistance impaired glucose metabolism animal and/or vitro models. Here we synthesize recent knowledge relative association between air-related plastic-derived incidence T2D, discussing mechanistic links suggested literature. We then anticipate need future field candidate therapeutic strategies limiting pollution-induced damage models, SGLT-2 inhibitors. finally postulate guidelines prevention should consider pollution sex additional limit pandemic.

Language: Английский

Citations

4
Integrin A5B1-mediated endocytosis of polystyrene nanoplastics: Implications for human lung disease and therapeutic targets DOI
Mingming Han, Ji Liang, K. Wang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 176017 - 176017

Published: Sept. 3, 2024

Language: Английский

Citations

4