Endocrine Disruptor Chemicals and Children’s Health

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2671 - 2671

Published: Jan. 31, 2023

We are all exposed to endocrine-disrupting chemicals (EDCs) starting from embryonic life. The fetus and child set up crucial developmental processes allowing adaptation the environment throughout life: they extremely sensitive very low doses of hormones EDCs because developing organisms. Considering origin well-being diseases, every adult organism expresses consequences in which it developed. molecular mechanisms through main manifest their effects potential association with endocrine disorders, such as diabetes, obesity, thyroid disease alteration adrenal hormones, will be reviewed here. Despite 40 years having passed since first study on EDCs, little is yet known about them; therefore, our purpose take stock situation establish a point for further studies. Since there plenty evidence showing that exposure may adversely impact health adults children altered function-suggesting link endocrinopathies-it essential this context bear mind what already disruptors deepen knowledge rules conduct aimed at limiting EDCs' negative effects. during COVID-19 pandemic an increase disruptor has been reported, also useful address new phenomenon better understanding its basis consequences.

Language: Английский

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Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men

Frontiers in Endocrinology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 7, 2021

Male reproductive health has declined as indicated by increasing rates of cryptorchidism, i.e., undescended testis, poor semen quality, low serum testosterone level, and testicular cancer. Exposure to endocrine disrupting chemicals (EDCs) been proposed have a role in this finding. In utero exposure antiandrogenic EDCs, particularly at sensitive period fetal development, the so-called 'masculinization programming window (MPW)', can disturb development function. Low androgen effect during MPW cause both short- long-term disorders. A concurrent EDCs may also affect function or damage cells. Evidence from animal studies supports male However, evidence epidemiological is relatively mixed. article, we review current literature that evaluated relationship between prenatal EDC exposures anogenital distance, congenital penile abnormality called hypospadias. We on association early life postnatal hypothalamic-pituitary-gonadal axis hormone levels

Language: Английский

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Endocrine disruptors and the male reproductive system

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2021, Volume and Issue: 35(5), P. 101567 - 101567

Published: Aug. 14, 2021

In recent years, there has been an increased incidence in several of the most common reproductive disorders, including hypospadias and cryptorchidism newborns, testicular cancer lower sperm quality young adult males. addition, timing puberty also changed over time. Although cause these effects is a matter intense debate, link with presence ubiquitous compounds environment, or exposure to specific groups medications during foetal life, suggested. Results from epidemiological experimental studies, as well clinical observations humans indicate that endocrine-disrupting chemicals may be associated those disorders. this review, we will summarize results studies utilising human cells tissue. Due increasing public interest recently published data, main focus on prenatal mild analgesics.

Language: Английский

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Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5486 - 5486

Published: March 13, 2023

Benign prostatic hyperplasia (BPH) is an age-related disorder, which one of the most prevalent and costly benign neoplasms in men with over 94 million cases worldwide. Starting before or around 50 years age, there a linear increase prostate volume BPH symptoms, are influenced by changes hormonal, inflammatory, growth factors, cell receptor signaling, diet, physical activity, microbiome that leads to cellular proliferation. While current pharmaceutical surgical treatments currently available, each treatment has serious side effects. This dilemma motived seek without negative effects from medicinal plants such as botanicals, phytochemicals, vitamins have established safety records. narrative overview focuses on several phytochemicals widely used emphasizes how, some cases, combinations these natural ingredients may provide better symptom relief compared utilization single plant product (monotherapy). Finally, this highlights vitro, vivo animal studies mainly clinical data journal reports published past 5 January 2018 2023 nutraceuticals. Notably, evolving perspective rethinking role usage play; is, they hold promise likely alleviate symptoms.

Language: Английский

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Anthocyanins Prevent AAPH-Induced Steroidogenesis Disorder in Leydig Cells by Counteracting Oxidative Stress and StAR Abnormal Expression in a Structure-Dependent Manner

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 508 - 508

Published: Feb. 17, 2023

Testosterone deficiency may increase the risk of sexual dysfunction and failure spermatogenesis. Oxidative stress that is derived from destruction homeostasis, disease, exposure to contaminants can damage steroidogenicity process in Leydig cells, resulting a reduction testosterone synthesis. Anthocyanins are group innoxious antioxidants widely recognized food sources, an ideal candidate relieve oxidative stress-related steroidogenesis disorder. However, there still major gap our knowledge structure-function relationship anthocyanin on activity mentioned above. In present study, four anthocyanins including cyanidin-3-glucoside (Cy-3-glu), delphinidin-3-glucoside (Dp-3-glu), pelargonidin-3-glucoside (Pg-3-glu), cyanidin-3,5-diglucoside (Cy-3,5-diglu) were applied reverse generation after employing 2,2'-Azobis(2-amidinopropane)-dihydrochloride (AAPH) as inducer R2C cells. The results demonstrated all kinds inhibit ROS generation, alleviate mitochondrial membrane potential damage, contribute increased testosterone. Among them, Cy-3,5-diglu with diglycoside performed best antioxidative ability improved cell upregulated expression steroidogenic acute regulatory protein (StAR). molecular docking further revealed direct combination between StAR, suggesting monosaccharide more likely interact StAR than diglycoside. Taken together, these data indicate recipient cells under submitted exhibited structure-dependent manner. could be considered ingredients against stress-induced deficiency.

Language: Английский

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Effects of cigarette smoking on semen quality, reproductive hormone levels, metabolic profile, zinc and sperm DNA fragmentation in men: results from a population-based study

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 18, 2023

Background Cigarette smoking seems to have a negative impact on men’s reproductive health, but our knowledge of its effects the function Russian men is still very limited. The purpose this study was evaluate effect cigarette semen quality, including sperm DNA fragmentation, hormonal, zinc and metabolic status in young from general multi-ethnic population (n=1,222, median age 23 years) find out ethno-specific by comparing male groups different ethnicity. Methods Each participant filled standardized questionnaire, provided one blood sample. Semen parameters, serum hormones, lipids, glucose, uric acid seminal were analyzed. Participants classified as smokers (n=450) non-smokers (n=772), stratified into moderate (≤10 cigarettes/day) heavy (>10 smokers. Results In entire population, characterized decrease volume, total count, concentration motility, an increase fragmentation teratozoospermia compared with (p<0.05). There also reduction level well impairment health No significant differences between found for levels LH, FSH, inhibin B, testosterone estradiol. second part study, most numerous ethnic Slavs (n=654), Buryats (n=191), Yakuts (n=125) selected population. Among three groups, intensity higher than or suggesting greater tobacco addiction Asians. A parameters levels, observed only (p<0.05); triglyceride revealed (p<0.05), no changes detected Buryats. Conclusion We concluded that has function, probably due activity antioxidant system, which yet be elucidated.

Language: Английский

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Association between serum testosterone level and cardiovascular health in US male adults: results from the 2013-2016 NHANES

The Journal of Sexual Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Language: Английский

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Association between dietary intake estimated levels of PCDD/Fs and human sperm quality

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108831 - 108831

Published: Jan. 1, 2025

Language: Английский

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RETHINKING LOW TESTOSTERONE IN OLDER MEN: ASSOCIATION WITH OBESITY RATHER THAN AGING

Urology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 867 - 867

Published: Feb. 28, 2025

Background/Objectives: Modern societal stressors have been linked to declining testosterone levels among young men, contributing somatic, psychological, and sexual health problems. Despite growing evidence suggesting a link between trace elements testosterone-related symptoms, there are only few comprehensive analyses on younger populations. This study's aim was examine how serum modulate the relationship symptom severity. Methods: cross-sectional study included 225 men seeking infertility consultation in Japan. Serum total free were measured, along with self-reported symptoms using Aging Males' Symptoms scale (somatic, sexual) Erection Hardness Score. The concentrations of 20 measured. We used unsupervised clustering classify participants based severity then compared distribution resulting clusters. Results: Three distinct clusters emerged: (1) lowest highest severity, (2) intermediate, (3) minimal symptoms. Interestingly, intermediate cluster displayed low but Eleven (phosphorus, sulfur, potassium, calcium, iron, zinc, arsenic, rubidium, strontium, molybdenum, cesium) identified as potential contributors dynamics. Weighted quantile sum regression indicated that phosphorus, molybdenum negatively influenced outcomes, whereas zinc beneficial. Conclusions: element profiles significantly associated men. Targeted interventions may address decline its implications. These findings help develop tailored strategies for optimizing male health.

Language: Английский

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