Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 6, 2023

Hydrogels with tailor-made swelling-shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients metabolites, well drug diffusion release, hydrogels high capacity been widely applicated full-thickness skin healing tissue regeneration, delivery. Nevertheless, fields adhesives internal soft-tissue healing, bioelectronics, non-swelling play very important functions owing to their stable macroscopic dimension physical performance physiological environment. Moreover, negative behavior (i.e., shrinkage) can be exploited drive noninvasive closure, achieve resolution enhancement hydrogel scaffolds. In addition, it help push out entrapped drugs, thus promote release. However, there still has not general review constructions applications from viewpoint properties. Therefore, this summarizes tactics employed so far tailoring applications. And relatively comprehensive understanding current progress future challenge different features provided potential clinical translations.

Language: Английский

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Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Materials Today Bio, Journal Year: 2022, Volume and Issue: 16, P. 100412 - 100412

Published: Aug. 29, 2022

Due to microbial infections dramatically affect cell survival and increase the risk of implant failure, scaffolds produced with antimicrobial materials are now much more likely be successful. Multidrug-resistant without suitable prevention strategies increasing at an alarming rate. The ability cells organize, develop, differentiate, produce a functioning extracellular matrix (ECM) create new functional tissue can all controlled by careful control microenvironment. This review covers present state advanced develop properties for bone, oral tissue, skin, muscle, nerve, trachea, cardiac other engineering applications. focuses on development against bacteria fungi using wide range materials, including polymers, biopolymers, glass, ceramics antimicrobials agents such as antibiotics, antiseptics, peptides, metals, carbon nanomaterials, combinatorial strategies, includes discussions mechanisms involved in these approaches. toxicological aspects also analyzed ensure future technological transfer clinics. main methods characterizing scaffolds' antibiofilm described. production porous supports, electrospinning, phase separation, gas foaming, porogen method, polymerization solution, fiber mesh coating, self-assembly, membrane lamination, freeze drying, 3D printing bioprinting, among others, included this article. These important advances materials-based regenerative medicine offer many promising avenues material design tissue-engineering communities.

Language: Английский

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pH-Responsive PVA/BC-f-GO Dressing Materials for Burn and Chronic Wound Healing with Curcumin Release Kinetics

Polymers, Journal Year: 2022, Volume and Issue: 14(10), P. 1949 - 1949

Published: May 11, 2022

Polymeric materials have been essential biomaterials to develop hydrogels as wound dressings for sustained drug delivery and chronic healing. The microenvironment healing is created by biocompatibility, bioactivity, physicochemical behavior. Moreover, a bacterial infection often causes the process. cellulose (BC) was functionalized using graphene oxide (GO) hydrothermal method cellulose-functionalized-Graphene (BC-f-GO). A simple blending used crosslink BC-f-GO with polyvinyl alcohol (PVA) tetraethyl orthosilicate (TEOS) crosslinker. structural, morphological, wetting, mechanical tests were conducted Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), water contact angle, Universal testing machine (UTM). release of Silver-sulphadiazine kinetics studied at various pH levels different mathematical models (zero-order, first-order, Higuchi, Hixson, Korsmeyer–Peppas, Baker–Lonsdale). antibacterial properties against Gram-positive Gram-negative severe infection-causing pathogens. These composite presented potential anticancer activities U87 cell line an increased GO amount. result findings show that these physical-mechanical inherent antimicrobial controlled release, making them ideal approach skin As result, discovered be biomaterial

Language: Английский

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Recent perspective of polymeric biomaterial in tissue engineering– a review

Materials Today Chemistry, Journal Year: 2023, Volume and Issue: 34, P. 101818 - 101818

Published: Nov. 18, 2023

Language: Английский

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Fundamental properties of smart hydrogels for tissue engineering applications: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127882 - 127882

Published: Nov. 10, 2023

Language: Английский

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Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications

ACS Omega, Journal Year: 2023, Volume and Issue: 8(18), P. 15909 - 15919

Published: March 27, 2023

Biopolymer-based hydrogels have several advantages, including robust mechanical tunability, high biocompatibility, and excellent optical properties. These can be ideal wound dressing materials advantageous to repair regenerate skin wounds. In this work, we prepared composite by blending gelatin graphene oxide-functionalized bacterial cellulose (GO-f-BC) with tetraethyl orthosilicate (TEOS). The were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscope (AFM), water contact angle analyses explore functional groups their interactions, surface morphology, wetting behavior, respectively. swelling, biodegradation, retention tested respond the biofluid. Maximum swelling was exhibited GBG-1 (0.01 mg GO amount) in all media (aqueous = 1902.83%, PBS 1546.63%, electrolyte 1367.32%). All hemocompatible, as hemolysis less than 0.5%, blood coagulation time decreased hydrogel concentration amount increased under vitro standard conditions. unusual antimicrobial activities against Gram-positive Gram-negative strains. cell viability proliferation an amount, maximum values found for GBG-4 (0.04 fibroblast (3T3) lines. mature well-adhered morphology of 3T3 cells samples. Based on findings, these would a potential material healing applications.

Language: Английский

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Fabrication of Bilayer Nanofibrous-Hydrogel Scaffold from Bacterial Cellulose, PVA, and Gelatin as Advanced Dressing for Wound Healing and Soft Tissue Engineering

ACS Omega, Journal Year: 2024, Volume and Issue: 9(6), P. 6527 - 6536

Published: Feb. 1, 2024

Tissue engineering is currently one of the fastest-growing areas engineering, requiring fabrication advanced and multifunctional materials that can be used as scaffolds or dressings for tissue regeneration. In this work, we report a bilayer material prepared by electrospinning hybrid poly(vinyl alcohol) (PVA) bacterial cellulose (BC NFs) (top layer) over highly interconnected porous 3D gelatin-PVA hydrogel obtained freeze-drying process (bottom layer). The techniques were combined to produce an with synergistic effects on physical biological properties two materials. was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), water contact measurement system (WCMS). Studies swelling, degradability, porosity, drug release, cellular antibacterial activities performed standardized procedures assays. FTIR confirmed cross-linking both top bottom layers, SEM showed structure layer, random deposition NFs surface, aligned in cross section. angle (WCA) hydrophilic surface material. Swelling analysis high degradation good stability. released Ag-sulfadiazine sustained controlled manner against severe disease-causing gram + ive −ive (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa) strains. vitro studies fibroblasts (3T3) human embryonic kidneys (HEK-293), which desirable cell viability, proliferation, adhesion bilayer. Thus, effect resulted potential wound dressing healing soft engineering.

Language: Английский

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A bifunctional endolytic alginate lyase with two different lyase catalytic domains from Vibrio sp. H204

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 13, 2024

Alginate lyases can fully degrade alginate into various size-defined unsaturated oligosaccharide products by β -elimination. Here, we identified the bifunctional endolytic lyase Aly35 from marine bacterium Vibrio sp. Strain H204. The enzyme is classified polysaccharide 7 superfamily and contains two catalytic domains. relationship function of domains are not well known. Thus, full-length recombinant its truncated proteins Aly35-CD1 (catalytic domain 1), Aly35-CD2 2 domain) were constructed. three enzymes showed similar biochemical characteristics exhibited temperature pH stability. Further research that efficiently alginate, polymannuronate (PM) polyguluronate (PG) a series oligosaccharides, while exhibits greater PM-degrading activity than but degraded PG efficiently. results suggest (Trp 295 -His 582 ) critical for PG-degrading activity, has (Leu 53 -Lys 286 higher both together confer increased (including M-blocks G blocks)-degrading activity. truncations will be useful tools structural analyses preparing bioactive especially used to prepare unit–rich oligosaccharides alginate.

Language: Английский

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Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 5082 - 5106

Published: July 15, 2024

In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs regenerates fractured bones. Bone multihierarchical complex structure, it performs several essential biofunctions, including maintaining mineral balance structural support protecting soft organs. Protein-based gained interest developing ideal scaffolds as emerging biomaterials for healing regeneration, challenging to design substitutes perfect biomaterials. Several polymers, collagen, keratin, gelatin, serum albumin, etc., are potential materials due cytocompatibility, controlled biodegradability, high biofunctionalization, tunable mechanical characteristics. While numerous studies indicated encouraging possibilities proteins BTE, there still major challenges concerning stability physiological conditions, continuous release growth factors bioactive molecules. Robust derived from can be used replace broken or diseased biocompatible substitute; proteins, being biopolymers, provide engineering. Herein, recent developments protein cutting-edge engineering addressed this review within 3–5 years, focus on significant future perspectives. The first section discusses fundamentals anatomy scaffolds, second describes fabrication techniques scaffolds. third highlights importance applications BTE. Hence, development state-of-the-art has been discussed, highlighting

Language: Английский

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Recent progress of electrospun nanofibers as burning dressings

RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14374 - 14391

Published: Jan. 1, 2024

Burns are a global public health problem, which brings great challenges to and the economy.

Language: Английский

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