Recent perspective of polymeric biomaterial in tissue engineering– a review

Materials Today Chemistry, Journal Year: 2023, Volume and Issue: 34, P. 101818 - 101818

Published: Nov. 18, 2023

Language: Английский

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Fundamental properties of smart hydrogels for tissue engineering applications: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127882 - 127882

Published: Nov. 10, 2023

Language: Английский

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Fabrication of Bilayer Nanofibrous-Hydrogel Scaffold from Bacterial Cellulose, PVA, and Gelatin as Advanced Dressing for Wound Healing and Soft Tissue Engineering

ACS Omega, Journal Year: 2024, Volume and Issue: 9(6), P. 6527 - 6536

Published: Feb. 1, 2024

Tissue engineering is currently one of the fastest-growing areas engineering, requiring fabrication advanced and multifunctional materials that can be used as scaffolds or dressings for tissue regeneration. In this work, we report a bilayer material prepared by electrospinning hybrid poly(vinyl alcohol) (PVA) bacterial cellulose (BC NFs) (top layer) over highly interconnected porous 3D gelatin-PVA hydrogel obtained freeze-drying process (bottom layer). The techniques were combined to produce an with synergistic effects on physical biological properties two materials. was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), water contact measurement system (WCMS). Studies swelling, degradability, porosity, drug release, cellular antibacterial activities performed standardized procedures assays. FTIR confirmed cross-linking both top bottom layers, SEM showed structure layer, random deposition NFs surface, aligned in cross section. angle (WCA) hydrophilic surface material. Swelling analysis high degradation good stability. released Ag-sulfadiazine sustained controlled manner against severe disease-causing gram + ive −ive (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa) strains. vitro studies fibroblasts (3T3) human embryonic kidneys (HEK-293), which desirable cell viability, proliferation, adhesion bilayer. Thus, effect resulted potential wound dressing healing soft engineering.

Language: Английский

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Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 5082 - 5106

Published: July 15, 2024

In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs regenerates fractured bones. Bone multihierarchical complex structure, it performs several essential biofunctions, including maintaining mineral balance structural support protecting soft organs. Protein-based gained interest developing ideal scaffolds as emerging biomaterials for healing regeneration, challenging to design substitutes perfect biomaterials. Several polymers, collagen, keratin, gelatin, serum albumin, etc., are potential materials due cytocompatibility, controlled biodegradability, high biofunctionalization, tunable mechanical characteristics. While numerous studies indicated encouraging possibilities proteins BTE, there still major challenges concerning stability physiological conditions, continuous release growth factors bioactive molecules. Robust derived from can be used replace broken or diseased biocompatible substitute; proteins, being biopolymers, provide engineering. Herein, recent developments protein cutting-edge engineering addressed this review within 3–5 years, focus on significant future perspectives. The first section discusses fundamentals anatomy scaffolds, second describes fabrication techniques scaffolds. third highlights importance applications BTE. Hence, development state-of-the-art has been discussed, highlighting

Language: Английский

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Hydrogels: Classifications, fundamental properties, applications, and scopes in recent advances in tissue engineering and regenerative medicine – A comprehensive review

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(10), P. 105968 - 105968

Published: Aug. 17, 2024

Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.

Language: Английский

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Eco-friendly bio-nanocomposites: pioneering sustainable biomedical advancements in engineering

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 9, 2024

Biomedical nanocomposites, which are an upcoming breed of mischievous materials, have ushered in a new dimension the healthcare sector. Incorporating these materials tends to boost features this component already possesses and give might things components could not withstand alone. The biopolymer, carries nanoparticles, can simultaneously improve composite's stiffness biological characteristics, vice versa. This increases options composite number times it be used. bio-nanocomposites nanoparticles enable ecocompatibility medicine their biodegradability, they, way, ecological sustainability. outcome is improved properties its associated positive impact on environment. They broad applications antimicrobial agents, drug carriers, tissue regeneration, wound care, dentistry, bioimaging, bone filler, among others. dissertation elements emphasizes production techniques, diverse medicine, match-up issues, future-boasting prospects field. Through utilization such scientists develop more suitable for environment healthy biomedical solutions, world way improves as well.

Language: Английский

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Dual-sided centripetal microgrooved poly (D,L-lactide-co-caprolactone) disk encased in immune-regulating hydrogels for enhanced bone regeneration

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101436 - 101436

Published: Jan. 5, 2025

Well-designed artificial scaffolds are urgently needed due to the limited self-repair capacity of bone, which hampers effective regeneration in critical defects. Optimal must provide physical guidance recruit cells and immune regulation improve regenerative microenvironment. This study presents a novel scaffold composed dual-sided centripetal microgrooved poly(D,L-lactide-co-caprolactone) (PLCL) film combined with dynamic hydrogel containing prednisolone (PLS)-loaded Prussian blue nanoparticles (PB@PLS). The microgrooves on surface PLCL were imprinted using micropatterned polydimethylsiloxane (PDMS) template. Following aminolysis, was covalently grafted EM-7 peptide via glutaraldehyde. Functional group analysis, morphology hydrophilicity evaluated X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), an optical contact angle measuring instrument, respectively. Bone regeneration-related (e.g., bone marrow mesenchymal stem cells, macrophages, Schwann endothelial cells) cultured films tended align along stripes migrate from periphery toward center region vitro. Subsequently, encapsulated immune-regulating synthesized thiol-modified gelatin Cu2+ presence PB@PLS nanoparticles, demonstrated excellent antioxidant properties. significantly accelerated critical-sized regeneration, as evidenced by increase volume newly formed histological images vivo. innovative approach holds substantial promise for clinical applications broader tissue repair.

Language: Английский

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Revolutionizing Bone Regeneration: Vascularized Bone Tissue Engineering with Advanced 3D Printing Technology

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

ABSTRACT The repair and functional reconstruction of bone defects resulting from trauma, surgical resection, degenerative diseases, congenital malformations are major clinical challenges. Bone tissue engineering has significant advantages in the treatment severe defects. Vascularized scaffolds gradually attracting attention development because their excellent biomimetic properties efficient efficiency. Three‐dimensional (3D) printing technology, which can be used to fabricate structures at different scales using a wide range materials, been production vascularized scaffolds. This review discusses research progress 3D for Angiogenesis‐osteogenesis coupling regeneration process is first introduced, followed by summary technologies, inks, bioactive factors Notably, this focuses on structural design strategies Finally, application medicine, as well challenges outlooks future development, described.

Language: Английский

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Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 052001 - 052001

Published: July 8, 2024

Abstract Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular molecular levels. Quick wound problems associated with traditional techniques are being overcome multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, now considered promising class well-suited porous materials for in addition other applications. This detailed literature review provides an overview latest developments MOFs We have discussed synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, The possible major challenges limitations been discussed, along conclusions future perspectives. addresses MOFs-based several angles covers most current subject. readers may discover how advanced discipline by producing more inventive, useful, successful dressings. It influences development generations biomaterials wounds.

Language: Английский

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Current progress of protein-based dressing for wound healing applications – A review

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(15), P. 2402 - 2445

Published: July 17, 2024

Protein-based wound dressings have garnered increasing interest in recent years owing to their distinct physical, chemical, and biological characteristics. The intricate molecular composition of proteins gives rise unique characteristics, such as exceptional biocompatibility, biodegradability, responsiveness, which contribute the promotion healing. Wound healing is an ongoing process influenced by multiple causes, it consists four phases. Various treatments been developed repair different types skin wounds, thanks advancements medical technology recognition diverse nature wounds. This review has literature reviewed within last 3-5 years-the progress development protein fundamental properties ideal dressing. Herein, strides protein-based state-of-the-art dressing emphasize significant challenges summarize future perspectives for applications.

Language: Английский

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