Polymers,
Journal Year:
2024,
Volume and Issue:
16(23), P. 3353 - 3353
Published: Nov. 29, 2024
In
this
work,
new
materials
based
on
the
blends
of
polyvinyl
alcohol
(PVA),
pyrrolidone
(PVP),
chitosan
(CS),
and
polydopamine
(PDA)
have
been
prepared.
Fourier
Transform
Infrared
Spectra
conducted
to
verify
presence
individual
components
in
composite
materials.
EDX
elemental
analysis
showed
a
clear
view
element’s
materials,
with
maximum
values
for
carbon
oxygen.
Atomic
force
microscopy
(AFM)
was
used
observe
surface
topography
measure
roughness.
case
polymers,
CS
presented
higher
value
roughness
(Rq
=
3.92
nm
Ra
3.02
nm),
found
be
lowest
it
2.34
0.95
nm).
PVA
films
roughness,
which
3.38
2.11
composites,
highest
PVA,
PVP,
CS,
11.91
8.71
After
addition
polymeric
reduction
observed
7.49
5.15
The
than
that
polymers.
PDA
(PVA/PVP/CS)
led
decrease
Young’s
modulus.
elongation
percentage
PVA/PVP/CS/PDA
blend
without
(9.80%
vs.
5.68%
PVA/PVP/CS).
hydrophilic.
results
from
MTT
assay
all
tested
specimens
are
non-toxic,
manifested
by
significant
increase
viability
L929
cells
compared
control
cells.
However,
additional
studies
required
check
biocompatibility
samples.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(4)
Published: May 28, 2024
Abstract
Since
most
solid
tumors
have
a
low
pH
value,
pH‐responsive
drug
delivery
system
may
offer
broad
method
for
tumor‐targeting
treatment.
The
present
study
is
used
to
analyze
the
anticancer
activity
of
carvacrol‐zinc
oxide
quantum
dots
(CVC‐ZnO
QDs)
against
breast
cancer
cells
(MDA‐MB‐231).
CVC‐ZnO
QDs
demonstrate
responsive
and
are
specifically
released
within
acidic
tumor
microenvironment.
This
property
enables
targeted
exclusively
while
minimizing
impact
on
normal
cells.
To
synthesized
ZnO
QDs,
CVC
was
loaded
then
examined
by
X‐ray
diffraction,
ultraviolet‐visible,
Fourier
transform
infrared
spectrophotometer,
scanning
electron
microscopy‐energy
dispersive
X‐ray,
transmission
microscopy.
For
up
20
h,
release
in
different
pH‐buffered
solutions.
results
showed
that
carvacrol
stable
an
solution.
Further,
cytotoxicity
assay,
antioxidant,
lipid
peroxidation
activity,
reactive
oxygen
species,
mitochondrial
membrane
potential,
nuclear
damage,
ability
cause
apoptosis
were
all
examined.
Apoptosis
markers
such
as
Bcl2,
Bax,
caspase‐3,
caspase‐9,
also
studied.
In
conclusion,
destabilized
MDA‐MB‐231cells
under
its
microenvironment
regulated
apoptosis.
Inorganic Chemistry Communications,
Journal Year:
2023,
Volume and Issue:
159, P. 111749 - 111749
Published: Nov. 24, 2023
An
innovative
hydrogel
nanocomposite,
synthesized
from
a
hybrid
of
PAA,
PVP,
and
MoS2,
represents
pioneering
solution
for
pH-responsive
drug
delivery.
This
nanocomposite
is
specifically
tailored
the
controlled
release
5-Fluorouracil
(5-FU),
an
anti-cancer
agent.
The
infusion
MoS2
into
PAA-modified
PVP
imparts
distinct
feature,
further
enriched
by
incorporation
Span
80
surfactant,
culminating
in
creation
stable
niosomal
microemulsions
that
enhance
retention
5-FU.
paraffin
oil
helps
reduce
size
while
maintaining
their
quasi-spherical
shape.
To
characterize
this
study,
we
employed
FT-IR
spectroscopy
X-ray
diffraction
(XRD)
methods
our
analysis.
Additionally,
Dynamic
Light
Scattering
(DLS)
analysis
confirmed
presence
nanoparticles
within
nanocarriers,
with
average
dimension
nearly
315
nm
polydispersity
index
(PDI)
0.27.
These
entities
exhibit
spherical
morphology,
as
revealed
SEM
imaging.
Zeta
potential
measurements
highlight
negative
surface
charge
approximately
–33.5
mV.
Remarkably,
achieved
significant
loading
entrapment
efficiencies,
reaching
46
%
87.25
%,
respectively,
surpassing
those
reported
other
nanocarriers
previous
studies.
Cellular
experiments
conducted
on
A549
L929
cell
lines
showcased
enhanced
anticancer
activity
5-FU-loaded
assessed
side
effects.The
results
underscore
promising
nanocarrier
favorable
strategy
delivering
drugs
cancer
treatment.
