Healthy lifestyle behaviors, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: A cohort study

PLoS Medicine, Journal Year: 2023, Volume and Issue: 20(1), P. e1004135 - e1004135

Published: Jan. 10, 2023

Background The influence of overall lifestyle behaviors on diabetic microvascular complications remains unknown. In addition, the potential mediating biomarkers underlying association is unclear. This study aimed to examine associations combined factors with risks total and individual among patients type 2 diabetes (T2D) explore mediation effects metabolic biomarkers. Methods findings retrospective cohort included 15,104 T2D free macro- at baseline (2006 2010) from UK Biobank. Healthy noncurrent smoking, recommended waist circumference, regular physical activity, healthy diet, moderate alcohol drinking. Outcomes were ascertained using electronic health records. Over a median 8.1 years follow-up, 1,296 cases composite occurred, including 558 retinopathy, 625 kidney disease, 315 neuropathy, some having or 3 simultaneously. After multivariable adjustment for sociodemographic characteristics, history hypertension, glycemic control, medication histories, hazard ratios (95% confidence intervals (CIs)) participants adhering 4 5 low-risk versus 0 1 0.65 (0.46, 0.91) 0.43 (0.30, 0.61) 0.46 (0.29, 0.74) 0.54 (0.43, 0.68) outcome (all Ps -trend ≤0.01). Further, population-attributable fraction CIs) poor adherence (<4 factors) ranged 25.3% (10.0%, 39.4%) 39.0% (17.7%, 56.8%). albumin, HDL-C, triglycerides, apolipoprotein A, C-reactive protein, HbA 1c collectively explained 23.20% (12.70%, 38.50%) between complications. key limitation current analysis was underreporting because identified via Conclusions Adherence associated significantly lower risk in T2D, favorable partially mediated through improving systemic inflammation, liver function, lipid profile.

Language: Английский

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10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025

Diabetes Care, Journal Year: 2024, Volume and Issue: 48(Supplement_1), P. S207 - S238

Published: Dec. 9, 2024

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide components diabetes care, general treatment goals guidelines, tools evaluate quality care. Members ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating Standards annually, or more frequently as warranted. For a detailed description standards, statements, reports, well evidence-grading system full list Committee members, please refer Introduction Methodology. Readers who wish comment on invited do so at professional.diabetes.org/SOC.

Language: Английский

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Association between prediabetes and adverse outcomes in heart failure

Diabetes Obesity and Metabolism, Journal Year: 2021, Volume and Issue: 23(11), P. 2476 - 2483

Published: July 6, 2021

Patients with heart failure (HF) and diabetes experienced significantly worse outcomes than those without diabetes. However, data on the prognostic impact of prediabetes in HF are inconclusive. This meta-analysis aimed to explore association between risk all-cause mortality adverse cardiac patients HF.We searched multiple electronic databases (PubMed, Embase Google Scholar) for relevant studies up 31 March 2021. Studies were included analysis if multivariable adjusted relative risks reported compared normoglycaemia. Random-effects models used calculate pooled hazard ratios (HRs) 95% confidence intervals (CIs).Twelve comprising 28 643 associated prediabetes. The prevalence ranged from 9.6% 37.2%. After a median follow-up duration 2.3 years, an increased (HR 1.29, CI 1.06-1.58), cardiovascular 1.59, 1.09-2.32), hospitalization 1.33, 1.09-1.61), and/or 1.22, 1.01-1.47), as well 1.21, 1.07-1.37).Prediabetes is prognosis HF. Further stratification effective treatment strategies needed improve prognosis.

Language: Английский

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The global burden of disease attributable to high fasting plasma glucose in 204 countries and territories, 1990–2019: An updated analysis for the Global Burden of Disease Study 2019

Diabetes/Metabolism Research and Reviews, Journal Year: 2022, Volume and Issue: 38(8)

Published: Aug. 24, 2022

Abstract Aims High fasting plasma glucose (HFPG) is an independent risk factor for several adverse health outcomes and has become a serious public problem. We aimed to evaluate the spatial pattern temporal trend of disease burden attributed HFPG from 1990 2019 using data Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019. Materials Methods Using GBD 2019, we estimated numbers age‐standardized rates deaths disability‐adjusted life years (DALYs) by calendar year, age, gender, country, region, Socio‐demographic Index (SDI), specific causes. The joinpoint regression analysis was used assess trends DALYs Results In globally, attributable were approximately 6.50 million 172.07 million, respectively, with 83.00 per 100,000 people 2104.26 people, respectively. From global have over doubled. rate showed increasing trend, particularly in males regions middle SDI or below. leading causes diabetes mellitus, ischaemic heart disease, stroke, chronic kidney disease. Conclusions important contributor regional burden. Necessary measures should be taken curb growing HFPG,

Language: Английский

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Predicting and preventing heart failure in type 2 diabetes

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(8), P. 607 - 624

Published: June 26, 2023

Language: Английский

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Burden of type 1 and type 2 diabetes and high fasting plasma glucose in Europe, 1990-2019: a comprehensive analysis from the global burden of disease study 2019

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 13, 2023

Introduction With population aging rampant globally, Europe faces unique challenges and achievements in chronic disease prevention. Despite this, comprehensive studies examining the diabetes burden remain absent. We investigated of type 1 2 diabetes, alongside high fasting plasma glucose (HFPG), from 1990-2019, to provide evidence for global strategies. Methods Disease estimates due HFPG were extracted GBD 2019 across Eastern, Central, Western Europe. analyzed trends 1990 by Joinpoint regression, examined correlations between Socio-demographic indices (SDI), healthcare access quality (HAQ), prevalence using linear regression models. The Population Attributable Fraction (PAF) was used described risks. Results In Europe, accounted 596 age-standardized disability-adjusted life years (DALYs) per 100,000 people 2019, lower than globally. markedly higher males escalated with increasing age. Most DALYs showing regional inconsistency, highest Central From attributable rose faster Eastern slower led 2794 crude 2019. Type burdens correlated positively negatively SDI HAQ. High BMI (PAF 60.1%) dietary risks 34.6%) significant risk factors. Conclusion Europe’s average, but substantial reflecting heterogeneity. Altered composition suggested increased YLDs. Addressing heavy both types necessitate region-specific interventions reduce risk, improve systems, offer cost-effective care.

Language: Английский

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Associations Between Life's Essential 8 and Chronic Kidney Disease

Journal of the American Heart Association, Journal Year: 2023, Volume and Issue: 12(24)

Published: Dec. 8, 2023

Chronic kidney disease (CKD) is closely associated with cardiovascular disease. We aimed to examine the association of Life's Essential 8 (LE8), recently updated measurement health, prevalence CKD among US adults.

Language: Английский

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Lifestyle factors and their relative contributions to longitudinal progression of cardio-renal-metabolic multimorbidity: a prospective cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 18, 2024

Abstract Background The role of lifestyle factors and their relative contributions to the development mortality cardio-renal-metabolic multimorbidity (CRMM) remains unclear. Methods A study was conducted with 357,554 UK Biobank participants. CRMM defined as coexistence two or three diseases (CRMDs), including cardiovascular disease (CVD), type 2 diabetes (T2D) chronic kidney (CKD). prospective examined associations individual combined scores (diet, alcohol consumption, smoking, physical activity, sedentary behavior, sleep duration social connection) longitudinal progression from healthy first (FCRMD), then CRMM, ultimately death, using a multistate model. Subsequently, quantile G-computation employed assess contribution each factor. Results During median follow-up 13.62 years, played crucial in all transitions FCRMD, death. hazard ratios (95% CIs) per score increase were 0.91 (0.90, 0.91) 0.90 (0.89, for FCRMD 0.84 (0.83, 0.86), 0.87 (0.86, 0.89), (0.88, 0.93) risk healthy, respectively. Among seven factors, smoking status contributed high proportions whole progression, accounting 19.88–38.10%. High-risk diet largest proportion transition 22.53%. Less-frequent connection 28.81%. When we further consider disease-specific transitions, find that had slightly stronger T2D than CVD CKD. Conclusions Our indicates may have protective effect throughout informing more effective management treatment. Smoking status, diet, pivotal roles specific transitions.

Language: Английский

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Sex-specific risks for cardiovascular disease across the glycaemic spectrum: a population-based cohort study using the UK Biobank

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 32, P. 100693 - 100693

Published: Aug. 10, 2023

We sought to examine sex-specific risks for incident cardiovascular disease (CVD) across the full glycaemic spectrum.Using data from UK Biobank, we categorised participants' glycated haemoglobin (HbA1c) at baseline as low-normal (<35 mmol/mol), normal (35-41 pre-diabetes (42-47 undiagnosed diabetes (≥48 or diagnosed diabetes. Our outcomes were coronary artery (CAD), atrial fibrillation, deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, heart failure, and a composite outcome of any CVD. Cox regression estimated associations between HbA1c each outcome, sequentially adjusting socio-demographic, lifestyle, clinical characteristics.Among 427,435 people, CVD rates 16.9 9.1 events/1000 person-years men women, respectively. Both women with pre-diabetes, diabetes, and, more markedly, higher than those HbA1c, relative increases pronounced in men. Age-adjusted HRs ranged 1.30 1.47; 1.55 (1.49-1.61) 2.00 (1.89-2.12) (p-interaction <0.0001). Excess attenuated similar after lifestyle factors particularly obesity antihypertensive statin use (fully adjusted diabetes: 1.06 [1.02-1.11] 1.17 [1.10-1.24], respectively).Excess largely explained by modifiable factors, could be ameliorated attention weight reduction strategies greater medications. Addressing these risk reduce sex disparities among people without diabetes.Diabetes (#15/0005250) British Heart Foundation (SP/16/6/32726).

Language: Английский

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The National Clinical Care Commission Report to Congress: Leveraging Federal Policies and Programs to Prevent Diabetes in People With Prediabetes

Diabetes Care, Journal Year: 2023, Volume and Issue: 46(2), P. e39 - e50

Published: Jan. 26, 2023

Individuals with an elevated fasting glucose level, level after challenge, or hemoglobin A1c below the diagnostic threshold for diabetes (collectively termed prediabetes) are at increased risk type 2 diabetes. More than one-third of U.S. adults have prediabetes but fewer one in five aware diagnosis. Rigorous scientific research has demonstrated efficacy both intensive lifestyle interventions and metformin delaying preventing progression from to The National Clinical Care Commission (NCCC) was a federal advisory committee charged evaluating making recommendations improve programs related prevention its complications. In this article, we describe NCCC subcommittee that focused primarily on people prediabetes. These aim current activities by 1) increasing awareness diagnosis population basis; 2) availability of, referral to, insurance coverage Diabetes Prevention Program Medicare Program; 3) facilitating Food Drug Administration review approval prevention; 4) supporting enhance effectiveness prevention. Cognizant burden 1 diabetes, also highlight importance advance our understanding etiology opportunities

Language: Английский

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