BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2081 - 2081

Published: Aug. 3, 2023

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays significant role in the survival and development of neurons, being involved several diseases such as Alzheimer’s disease major depression disorder. The association between BDNF depressive disorder subject extensive research. Indeed, numerous studies indicate decreased levels are linked to an increased occurrence symptoms, neuronal loss, cortical atrophy. Moreover, it has been observed antidepressive therapy can help restore levels. In this review, we will focus on serotonergic imbalance associated stress conditions, particularly hypothalamic–pituitary–adrenal (HPA) axis dysregulation oxidative stress. All these features highly connected signaling pathways context disease, exploring topic aim advance our understanding disorder, improve diagnostic treatment approaches, potentially identify new therapeutic targets alleviate heavy burden society.

Language: Английский

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Unveiling the potential of selenium-enriched tea: Compositional profiles, physiological activities, and health benefits

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 145, P. 104356 - 104356

Published: Feb. 3, 2024

Language: Английский

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Impaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression

Redox Biology, Journal Year: 2025, Volume and Issue: 80, P. 103491 - 103491

Published: Jan. 8, 2025

Adolescent depression is a globally concerned mental health issue, the pathophysiological mechanisms of which remain elusive. Membrane lipids play crucial role in brain development and function, potentially serving as crossroad for abnormalities neurotransmitters, neuroendocrine, inflammation, oxidative stress, energy metabolism observed depressed adolescents. The primary aim this study was to investigate erythrocyte membrane lipid profile adolescent depression. A total 2838 were detected quantified 81 adolescents with 67 matched healthy using ultra-high performance liquid chromatography-mass spectrometry. Depressed exhibited significantly different characteristics compared controls. Specifically, levels cholesterol, sphingomyelins, ceramides increased, while ether decreased patients. Moreover, patients showed reduced polyunsaturated fatty acids elevated lipophilic index membrane, suggesting diminished fluidity. higher oxidized plasma malondialdehyde depression, indicating presence stress. Importantly, damage associated more severe depressive symptoms worse cognitive function In addition, fluidity may be partly responsible blunted niacin skin flushing response found conclusion, our results reveal impaired homeostasis implicate dysfunction brain. These findings offer new insights into underlying molecular highlighting potential counteracting promising avenue future therapeutic interventions.

Language: Английский

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How Oxidative Stress Induces Depression?

ASN NEURO, Journal Year: 2023, Volume and Issue: 15

Published: Jan. 1, 2023

Depression increasingly affects a wide range and large number of people worldwide, both physically psychologically, which makes it social problem requiring prompt attention management. Accumulating clinical animal studies have provided us with substantial insights disease pathogenesis, especially central monoamine deficiency, considerably promotes antidepressant research treatment. The first-line antidepressants mainly target the system, whose drawbacks include slow action treatment resistant. novel esketamine, targeting on glutamatergic rapidly robustly alleviates depression (including treatment-resistant depression), efficiency is shadowed by potential addictive psychotomimetic side effects. Thus, exploring pathogenesis necessary, for seeking more safe effective therapeutic methods. Emerging evidence has revealed vital involvement oxidative stress (OS) in depression, inspires to pursue antioxidant pathway prevention Fully uncovering underlying mechanisms OS-induced first step towards avenue, thus we summarize expound possible downstream pathways OS, including mitochondrial impairment related ATP neuroinflammation, glutamate excitotoxicity, brain-derived neurotrophic factor/tyrosine receptor kinase B dysfunction serotonin microbiota-gut-brain axis disturbance hypothalamic-pituitary-adrenocortical dysregulation. We also elaborate intricate interactions between multiple aspects, molecular mediating interplay. Through reviewing progress field, hope depict an integral overview how OS induces order provide fresh ideas targets final goal efficient disease.

Language: Английский

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Lactobacillus brevis-Fermented Gamma-Aminobutyric Acid Ameliorates Depression- and Anxiety-Like Behaviors by Activating the Brain-Derived Neurotrophic Factor-Tropomyosin Receptor Kinase B Signaling Pathway in BALB/C Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(6), P. 2977 - 2988

Published: Feb. 1, 2024

This study investigated the effects of Lactobacillus brevis-fermented gamma-aminobutyric acid (LB-GABA) on depressive and anxiety-like behaviors with underlying molecular mechanism in a chronic stress model BALB/c mice. LB-GABA attenuates both neuronal cell death increase monoamine oxidase activity induced by hydrogen peroxide. Behavioral tests revealed that GABA significantly increased sucrose preference reduced immobility time tail suspension forced swimming tests. exploration open arms elevated plus maze restored field. Moreover, lowered hormone inflammatory mediator levels. Mechanistically, protein levels BDNF TrkB, activating downstream targets (AKT, ERK, CREB), crucial for survival plasticity. Furthermore, protected hippocampal neurons from stress-induced serotonin dopamine Overall, has potential to alleviate depression symptoms neuroinflammation BDNF-TrkB signaling pathway.

Language: Английский

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Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 22, 2025

To determine the relative effectiveness of combination therapy antidepressants with low-dose methylfolate versus antidepressant monotherapy in patients depressive disorder. In an open-label clinical trial, forty-four disorder (6A70, 6A71, and 6A72 according to ICD-11) received evidence-based (either escitalopram 10-20 mg, sertraline 50-100 fluoxetine 20-40 duloxetine 30-60 mirtazapine 15-30 venlafaxine 75-150 trazodone amitriptyline 25-75 or clomipramine mg orally daily for 4 weeks). The experimental group, Group B was additionally given a dose 800 µg four weeks. psychometric testing depression achieved through administration Patient Health Questionnaire-9 (PHQ-9) on days 0, 14, 28, find improvement score day remission rate decrease time lag 14. Adverse effects were analyzed by self-assessment questionnaire observe tolerability. paired sample t-test independent applied analysis using SPSS v27.0. p-value ≤ 0.05 considered statistically significant. On low showed 40.33% symptoms, compared 26.43% (p-value < 0.05). This treatment strategy had no effect time-lag outcomes 14 28 not found Only one patient reported insomnia, while another mentioned irritability. Combination may provide safe effective NCT05931965.ClinicalTrials.gov. https://classic.clinicaltrials.gov/ct2/show/NCT05931965

Language: Английский

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Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 28, 2025

Language: Английский

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Novel therapeutic targets for major depressive disorder related to oxidative stress identified by integrative multi-omics and multi-trait study

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 19, 2024

Oxidative stress (OS) is strongly implicated in the pathophysiology of major depressive disorder (MDD) but molecular mechanisms remain largely unknown. The purpose this study to identify genes related both OS and MDD, further evaluate utility these as diagnostic markers potential treatment targets. We searched datasets MDD from Gene Expression Omnibus (GEO) database for differentially expressed (DEGs) also according GeneCards. Bioinformatics analyses machine learning algorithms were used hub mediating OS–MDD interactions. A summary data-based Mendelian randomization (SMR) approach was employed possible causal blood tissue eQLT data. These investigations identified 32 interactions, while SMR analysis KCNE1 (OR = 1.057, 95%CI 1.013–1.102, P value 0.010), MAPK3 1.023, 1.004–1.043, 0.020), STIP1 0.792, 0.641–0.979, 0.031) OS-related MDD. may thus serve useful therapeutic

Language: Английский

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Ginsenoside Re Prevents Depression-like Behaviors via Inhibition of Inflammation, Oxidative Stress, and Activating BDNF/TrkB/ERK/CREB Signaling: An In Vivo and In Vitro Study

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(36), P. 19838 - 19851

Published: Aug. 26, 2024

Depression is a widespread disease, with high mortality and recurrence rates. Recent studies have shown that elevated cytokine levels are implicated in the molecular mechanisms of depression. Oxidative stress contributes to stimulation production. Growing evidence suggests ginsenoside Re (Gs-Re) exerts neuroprotective effect on hippocampus by suppressing oxidative inflammation. However, mechanism Gs-Re treatment depression remain understudied. This study aimed evaluate antidepressant-like effects possible underlying mechanisms. In this article, was studied both vitro (H

Language: Английский

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Association between serum copper, zinc, and selenium concentrations and depressive symptoms in the US adult population, NHANES (2011–2016)

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 11, 2023

Abstract Background Evidence suggests that alterations in serum trace element concentrations are closely associated with mental illness. However, ​studies on the relationship between copper, zinc, and selenium depressive symptoms limited controversial results. We aimed to investigate association of these elements US adults. Methods Data from National Health Nutrition Examination Survey (NHANES) (2011–2016) were used this cross-sectional study. The Patient Questionnaire-9 Items (PHQ-9) was employed assess symptoms. Multiple logistic regression performed determine Results A total 4552 adults included. Subjects had higher copper (123.88 ± 1.87) than those without (116.99 0.86) ( p < 0.001). In Model 2, weighted analysis showed second (Q2) quartile zinc (odds ratio [OR] = 1.534, 95% confident interval [CI]: 1.018 2.313) significantly an increased risk Subgroup revealed third (Q3) fourth (Q4) quartiles (Q3: OR 2.699, CI: 1.285 5.667; Q4: 2.490, 1.026 6.046) also positively obese individuals after controlling for all confounders. no significant observed. Conclusions Obese high concentrations, as well general low susceptible Nevertheless, causal mechanisms underlying relationships need be further explored.

Language: Английский

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