Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(8), P. 2543 - 2559

Published: March 19, 2024

Abstract The recent introduction of new-generation immunoassay methods allows the reliable quantification structural brain markers in peripheral matrices. Neurofilament light chain (NfL), a neuron-specific cytoskeletal component released extracellular matrices after neuroaxonal impairment, is considered promising blood marker active pathology. Given its sensitivity to wide range neuropathological alterations, NfL has been suggested for use clinical practice as highly sensitive, but unspecific tool quantify While large efforts have put characterizing profile many neurological conditions, received far less attention potential biomarker major psychiatric disorders. Therefore, we briefly introduce injury, systematically review findings on cerebrospinal fluid and levels patients with primary conditions highlight opportunities pitfalls. Current evidence suggests an elevation depression, bipolar disorder, psychotic disorders, anorexia nervosa, substance disorders compared physiological states. However, strongly vary across diagnostic entities, stage, patient subgroups, are influenced by several demographic, clinical, analytical factors, which require accurate characterization. Potential applications measure psychiatry seen prognostic algorithms, exclude neurodegenerative disease, assessment toxicity different pharmacological compounds, longitudinal monitoring treatment response. high inter-individual variability lack neurobiological understanding release some main current limitations. Overall, this primer aims researchers clinicians field provide conceptual framework future research directions.

Language: Английский

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Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(16), P. 10362 - 10362

Published: Aug. 19, 2022

The physio-affective phenome of Long COVID-19 is predicted by (a) immune-inflammatory biomarkers the acute infectious phase, including peak body temperature (PBT) and oxygen saturation (SpO2), (b) subsequent activation immune oxidative stress pathways during COVID. purpose this study was to delineate effects PBT SpO2 infection, as well increased neurotoxicity on physical, psychological, social environmental domains health-related quality life (HR-QoL) in people with We recruited 86 participants COVID 39 normal controls, assessed WHO-QoL-BREF (World Health Organization Quality Life Instrument-Abridged Version, Geneva, Switzerland) (comprising depression, anxiety fibromyalgia-fatigue rating scales) measured (NT, comprising serum interleukin (IL)-1β, IL-18 caspase-1, advanced oxidation protein products myeloperoxidase, calcium insulin resistance) found that 70.3% variance HR-QoL explained regression phenome, lowered NT, whilst 61.5% calcium, PBT, SpO2, female sex vaccination AstraZeneca Pfizer. were mediated NT yielding severity which largely affects HR-QoL. In conclusion, HR-Qol neuro-immune neuro-oxidative

Language: Английский

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Increased insulin resistance due to Long COVID is associated with depressive symptoms and partly predicted by the inflammatory response during acute infection

Brazilian Journal of Psychiatry, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Some months after the remission of acute COVID-19, some individuals show depressive symptoms, which are predicted by increased peak body temperature (PBT) and decreased blood oxygen saturation (SpO2). The present study aimed to examine data on whether long COVID is associated with insulin resistance (IR) in association neuroimmune oxidative (NIO) processes during infectious phases.

Language: Английский

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Simple dysmood disorder, a mild subtype of major depression, is not an inflammatory condition: Depletion of the compensatory immunoregulatory system

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 375, P. 75 - 85

Published: Jan. 21, 2025

Language: Английский

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T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 64, P. 171 - 181

Published: Nov. 13, 2023

Immune-inflammatory pathways in major depressive disorder are confined to the dysmood (MDMD) phenotype (Maes et al., 2022). No studies have addressed immune profile of first episode MDMD (FE-MDMD).

Language: Английский

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T cell activation and deficits in T regulatory cells are associated with major depressive disorder and severity of depression

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 16, 2024

Abstract Major depressive disorder (MDD) is associated with T cell activation, but no studies have examined the combined effects of activation and deficits in regulatory (Treg) cells on severity acute phase MDD. Using flow cytometry, we determined percentage median fluorescence intensity CD69, CD71, CD40L, HLADR-bearing CD3+, CD4+, CD8+ cells, cannabinoid type 1 receptor (CB1), CD152 GARP (glycoprotein A repetitions predominant)-bearing CD25+ FoxP3 30 MDD patients 20 healthy controls unstimulated stimulated (anti-CD3/CD28) conditions. Based cytokine levels, assessed M1 macrophage, helper (Th)-1 cell, immune-inflammatory response system (IRS), growth, neurotoxicity immune profiles. We found that profiles (including IRS neurotoxicity) were significantly predicted by decreased numbers or GARP-bearing expression combination increases activated (especially CD40L+ expression). showed increased CD3+ CD71+, CD40L+, CD4+ HLADR+, HLADR+ CD71+ expression, lowered FoxP+ CB1+ as compared controls. The Hamilton Depression Rating Scale score was strongly (between 40% its variance) a lower number CB1 Treg one more subtypes CD40L+). In conclusion, cytotoxic along homeostatic defenses are important parts lead to enhanced responses and, result, neuroimmunotoxicity.

Language: Английский

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T cell activation and lowered T regulatory cell numbers are key processes in severe major depressive disorder: Effects of recurrence of illness and adverse childhood experiences

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 362, P. 62 - 74

Published: June 29, 2024

Language: Английский

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Association between depressive symptoms and cognitive function in the older population, and the mediating role of neurofilament light chain: Evidence from NHANES 2013–2014

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 360, P. 221 - 228

Published: May 30, 2024

This study aimed to investigate the potential mediating role of neurofilament light chain (NfL) level between depressive symptoms and cognitive function in older population. A total 495 adults (age ≥60 years) from National Health Nutrition Examination Survey (NHANES) participated this study. Cognitive was assessed using a combination Animal Fluency Test (AFT), Consortium Establish Registry for Alzheimer's Disease (CERAD) Digit Symbol Substitution (DSST). Word List Learning Test. Patient Questionnaire-9 (PHQ-9) used assess symptoms. Data on serum NfL(sNfL) were collected. Multiple linear regressions mediation analysis utilized examine associations. After adjusting confounding factors, proportions mediated by sNfL 19.65 %. The indirect effect significant (β[95 % CI]:-0.0089 [−0.0191, −0.0017],p = 0.040), while direct absence non-significant CI]: −0.0365 [−0.0739 0.0008],p 0.055). is an explorative cross-sectional with its limits generalizability ability establish definitive causal results should be interpreted caution due constraints imposed characteristics population relatively low overall level, symptoms, decline are interconnected, could mediate relationship among adults.

Language: Английский

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Lower Nerve Growth Factor Levels in Major Depression and Suicidal Behaviors: Effects of Adverse Childhood Experiences and Recurrence of Illness

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(7), P. 1090 - 1090

Published: July 18, 2023

Major depressive disorder (MDD) and its severe subtype, major dysmood (MDMD), are distinguished by activation of inflammatory growth factor subnetworks, which associated with recurrence illness (ROI) adverse childhood experiences (ACEs). Nerve (NGF) plays a crucial role in facilitating neuro-immune communications may regulate the response.

Language: Английский

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T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: April 17, 2023

Abstract Background Immune-inflammatory pathways in major depressive disorder are confined to the dysmood (MDMD) phenotype (Maes et al., 2022). No studies have addressed immune profile of first episode MDMD (FE-MDMD). Methods This study examines 48 cytokines/chemokines/growth factors, and classical M1, alternative M2, T helper (Th)-1, Th-2, Th-17 phenotypes, immune-inflammatory response system (IRS), compensatory immunoregulatory (CIRS), neuro-immunotoxicity profiles acute phase FE-MDMD (n=71) versus healthy controls (40). Results patients show significantly activated Th-1, IRS, CIRS, neurotoxicity, but not Th-2 or Th-17, compared controls. is accompanied by Th-1 polarization, while there no changes M1/M2 IRS/CIRS ratios. The top single indicator was far interleukin (IL)-16, followed at a distance TRAIL, IL-2R, tumor necrosis factor (TNF)-β. severity depression anxiety strongly associated with IRS (positively) (inversely) profiles, whereas suicidal behavior M1 activation. Around 56-60% variance depression, anxiety, scores explained IL-16, platelet-derived growth (PDGF) (both positively), IL-1 receptor antagonist (inversely). Increased neurotoxicity mainly driven TNF-α, IL-6 chemokine (CCL2, CCL11, CXCL1, CXCL10) signaling. Antidepressant-treated an increased ratio as drug-naïve patients. Conclusions positive regulation polarization cell activation (via binding IL-16 CD4), TNF, chemokine,

Language: Английский

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