Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 871, P. 161962 - 161962

Published: Feb. 10, 2023

Language: Английский

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Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis

Journal of Advanced Research, Journal Year: 2022, Volume and Issue: 52, P. 3 - 18

Published: Nov. 10, 2022

Microplastic pollution seriously threatens the health and safety of humans wildlife. Avian is one main species endangered by microplastics. However, damage mechanism microplastics to digestive system avian not clear. The gut-liver axis a bidirectional channel that regulates exchange information between gut liver also key target for tissue caused pollutants. This study aimed elucidate toxicity in role it. We constructed an exposure model environmental concentrations toxicological chickens reveal polystyrene (PS-MPs) 16S rRNA, transcriptomics metabolomics. PS-MPs changed death mode from apoptosis necrosis pyroptosis upregulating Caspase 8, disrupting intestinal vascular barrier, disturbing flora promoting accumulation lipopolysaccharide. Harmful metabolites were translocated through liver-gut axis, eliciting hepatic immune responses lipid metabolism disorders apoptosis. Liver injury involves multiple molecular effects mitochondrial dynamics disturbance, oxidative stress, endoplasmic reticulum cell cycle disturbance. Furthermore, metabolomics suggested caffeine melanin may be potential natural resistance substances Taken together, our data demonstrate avian, revealing critical will provide reference protecting populations.

Language: Английский

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Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 8307 - 8324

Published: March 4, 2024

Periodontitis is a chronic inflammatory disease closely associated with reactive oxygen species (ROS) involvement. Eliminating ROS to control the periodontal microenvironment and alleviate response could potentially serve as an efficacious therapy for periodontitis. Melatonin (MT), renowned its potent antioxidant anti-inflammatory characteristics, frequently employed scavenger in diseases. However, therapeutic efficacy of MT remains unsatisfactory due low water solubility poor bioavailability. Carbon dots have emerged promising innovative nanomaterial facile synthesis, environmental friendliness, cost. In this study, melatonin-derived carbon (MT-CDs) were successfully synthesized via hydrothermal method. The MT-CDs good biocompatibility feature excellent ROS-scavenging capacity without additional modification. vitro experiments proved that efficiently regulated intracellular ROS, which maintained mitochondrial homeostasis suppressed production mediators. Furthermore, findings from mouse model periodontitis indicated significantly inhibited deterioration alveolar bone reduced osteoclast activation inflammation, thereby contributing regeneration damaged tissue. terms mechanism, may scavenge preventing cellular damage factors by regulating nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. will offer vital understanding advancement secure effective platforms more biomedical applications.

Language: Английский

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Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens

Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: 25(3), P. 233 - 243

Published: March 1, 2024

Language: Английский

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ROS-mediated PPAR/RXR inhibition contributes to acetochlor-induced apoptosis and autophagy in Ctenopharyngodon idella hepatic cells

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 128, P. 684 - 694

Published: Aug. 24, 2022

Language: Английский

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Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 38(1), P. 78 - 89

Published: Oct. 7, 2022

Microplastics (MPs) seriously pollute and potentially threaten human health. Birds are sentinels of environmental pollutants, which respond quickly to contamination events reveal current exposure. Therefore, birds good bioindicators for monitoring pollutants. However, the mechanism lung injury in role PTEN/PI3K/AKT axis unknown. In this study, broilers treated with different polystyrene microplastics (PS-MPs) (0, 1, 10, 100 mg/L) were exposed drinking water 6 weeks analyze effect PS-MPs on broilers. The results showed that increase concentration, malonaldehyde (MDA) content increased, catalase (CAT) glutathione (GSH) activity decreased, further leading oxidative stress. caused PI3K/Akt/mTOR pathway be inhibited by phosphorylation, autophagy accelerated formation (LC3) degradation (p62), causing autophagy. tissues, expression Bax/Bcl-2 Caspase family MAPK signaling pathways (p38, ERK, JNK) an phosphorylation level, thus cell apoptosis. Our research could activate antioxidant system. system unbalance-regulated family, initiated apoptosis autophagy, turn led tissue damage chickens. These great significance toxicological study protection ecosystem.

Language: Английский

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The decrease of selenoprotein K induced by selenium deficiency in diet improves apoptosis and cell progression block in chicken liver via the PTEN/PI3K/AKT pathway

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 189, P. 20 - 31

Published: July 13, 2022

Language: Английский

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Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 367, P. 110180 - 110180

Published: Sept. 13, 2022

Language: Английский

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Micro-algal astaxanthin improves lambda-cyhalothrin-induced necroptosis and inflammatory responses via the ROS-mediated NF-κB signaling in lymphocytes of carp (Cyprinus carpio L.)

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 139, P. 108929 - 108929

Published: July 4, 2023

Language: Английский

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Selenium alleviates lead-induced CIK cells pyroptosis and inflammation through IRAK1/TAK1/IKK pathway

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 142, P. 109101 - 109101

Published: Sept. 26, 2023

Language: Английский

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