Polymer–drug conjugate therapeutics: advances, insights and prospects

Nature Reviews Drug Discovery, Journal Year: 2018, Volume and Issue: 18(4), P. 273 - 294

Published: Dec. 12, 2018

Language: Английский

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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 47(10), P. 3574 - 3620

Published: Jan. 1, 2018

Peptide- and protein-nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, prevention of disease. In this review, we focus on key roles played by peptides proteins in improving, controlling, defining performance nanotechnologies. Within framework, provide a comprehensive overview sequences structures utilised to biological physical stability nano-constructs, direct particles their target influence cellular tissue distribution, induce control responses, form polypeptide self-assembled nanoparticles. doing so, highlight great advances made field, well challenges still faced achieving clinical translation peptide- protein-functionalised nano-drug delivery vehicles, imaging species, active therapeutics.

Language: Английский

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Bright Aggregation‐Induced‐Emission Dots for Targeted Synergetic NIR‐II Fluorescence and NIR‐I Photoacoustic Imaging of Orthotopic Brain Tumors

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(29)

Published: May 28, 2018

Abstract Precise diagnostics are of significant importance to the optimal treatment outcomes patients bearing brain tumors. NIR‐II fluorescence imaging holds great promise for brain‐tumor with deep penetration and high sensitivity. This requires development organic fluorescent agents quantum yield (QY), which is difficult achieve. Herein, design synthesis a new molecule aggregation‐induced‐emission (AIE) characteristics reported orthotopic imaging. Encapsulation in polymer matrix yields AIE dots showing very QY 6.2% large absorptivity 10.2 L g −1 cm at 740 nm an emission maximum near 1000 nm. Further decoration c‐RGD targeted dots, afford specific selective tumor uptake, signal/background ratio 4.4 resolution up 38 µm. The NIR facilitates NIR‐I photoacoustic intrinsically deeper than and, more importantly, precise tumor‐depth detection through intact scalp skull. research demonstrates molecules their dual cancer diagnostics.

Language: Английский

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Tumor penetrating peptides for improved drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2016, Volume and Issue: 110-111, P. 3 - 12

Published: April 3, 2016

Language: Английский

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Synthetic amorphous silica nanoparticles: toxicity, biomedical and environmental implications

Nature Reviews Materials, Journal Year: 2020, Volume and Issue: 5(12), P. 886 - 909

Published: Sept. 16, 2020

Language: Английский

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Ligand‐Installed Nanocarriers toward Precision Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(13)

Published: July 28, 2019

Development of drug-delivery systems that selectively target neoplastic cells has been a major goal nanomedicine. One strategy for achieving this milestone is to install ligands on the surface nanocarriers enhance delivery tissues, as well internalization by cells, which improves accuracy, efficacy, and ultimately enhances patient outcomes. Herein, recent advances regarding development ligand-installed are introduced effect their design biological performance discussed. Besides academic achievements, progress in clinical trials presented, along with challenges faced these formulations. Lastly, future perspectives discussed, particular emphasis potential emerging precision therapies.

Language: Английский

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Liposome-based drug co-delivery systems in cancer cells

Materials Science and Engineering C, Journal Year: 2016, Volume and Issue: 71, P. 1327 - 1341

Published: Nov. 23, 2016

Language: Английский

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Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

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Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 320, P. 180 - 200

Published: Jan. 21, 2020

Language: Английский

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Antibody fragments as nanoparticle targeting ligands: a step in the right direction

Chemical Science, Journal Year: 2016, Volume and Issue: 8(1), P. 63 - 77

Published: Sept. 16, 2016

Recent advances in nanomedicine have shown that dramatic improvements nanoparticle therapeutics and diagnostics can be achieved through the use of disease specific targeting ligands.

Language: Английский

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