Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
11(8), P. 2096 - 2113
Published: Feb. 2, 2021
Cell
membranes
have
recently
emerged
as
a
new
source
of
materials
for
molecular
delivery
systems.
been
extruded
or
sonicated
to
make
nanoscale
vesicles.
Unlike
synthetic
lipid
polymeric
nanoparticles,
cell
membrane-derived
vesicles
unique
multicomponent
feature,
comprising
lipids,
proteins,
and
carbohydrates.
Because
contain
the
intrinsic
functionalities
signaling
networks
their
parent
cells,
they
can
overcome
various
obstacles
encountered
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(4), P. 2839 - 2891
Published: Jan. 1, 2021
Supramolecular
cancer
nanotheranostics
have
shown
promising
potentials
in
early-stage
diagnosis
and
personal
therapy.
Herein,
we
summarize
the
progress
of
supramolecular
provide
guidance
for
designing
new
targeted
theranostic
agents.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(8), P. 4932 - 4973
Published: Jan. 1, 2021
Antimicrobial
resistance
(AMR)
is
one
of
the
greatest
threats
to
human
health
that,
by
2050,
will
lead
more
deaths
from
bacterial
infections
than
cancer.
New
antimicrobial
agents,
both
broad-spectrum
and
selective,
that
do
not
induce
AMR
are
urgently
required.
peptides
(AMPs)
a
novel
class
alternatives
possess
potent
activity
against
wide
range
Gram-negative
positive
bacteria
with
little
or
no
capacity
AMR.
This
has
stimulated
substantial
chemical
development
peptide-based
antibiotics
possessing
improved
therapeutic
index.
review
summarises
recent
synthetic
efforts
their
impact
on
analogue
design
as
well
various
applications
in
AMP
development.
It
includes
modifications
have
been
reported
enhance
including
lipidation,
glycosylation
multimerization
through
broad
application
bio-orthogonal
chemistry,
perspectives
direction
future
research.
The
subject
area
primarily
next-generation
agents
rational
modification
AMPs.
further
serves
guide
toward
most
promising
directions
this
field
stimulate
scientific
attention,
new,
effective
selective
solutions
for
several
biomedical
challenges
which
peptidomimetics
being
applied.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
31(6)
Published: Oct. 23, 2020
Abstract
Foreign‐body
response
caused
by
implanted
biomaterials
seriously
impedes
the
function
of
implants
and
is
a
major
obstacle
to
development
implantable
medical
devices.
Recent
advances
in
devices
have
provided
strategies
resist
foreign‐body
response.
In
this
review,
mechanism
conventional
mitigate
briefly
introduced.
Then,
three
types
promising
resisting
materials
are
focused
advantages,
characteristics,
applications
each
material
discussed.
Finally,
prospects
put
forward
for
future
current
challenges
that
require
in‐depth
study.
Bioconjugate Chemistry,
Journal Year:
2019,
Volume and Issue:
30(2), P. 366 - 383
Published: Jan. 4, 2019
Oligonucleotide-based
agents
have
the
potential
to
treat
or
cure
almost
any
disease,
and
are
one
of
key
therapeutic
drug
classes
future.
Bioconjugated
oligonucleotides,
a
subset
this
class,
emerging
from
basic
research
being
successfully
translated
clinic.
In
review,
we
first
briefly
describe
two
approaches
for
inhibiting
specific
genes
using
oligonucleotides
--
antisense
DNA
(ASO)
RNA
interference
(RNAi)
followed
by
discussion
on
delivery
cells.
We
then
summarize
analyze
recent
developments
in
bioconjugated
including
those
possessing
GalNAc,
cell
penetrating
peptides,
$\alpha$-tocopherol,
aptamers,
antibodies,
cholesterol,
squalene,
fatty
acids,
nucleolipids.
These
novel
conjugates
provide
means
enhance
tissue
targeting,
internalization,
endosomal
escape,
target
binding
specificity,
resistance
nucleases,
more.
next
approved
patient
use
clinical
trials.
Finally,
state
field,
current
limitations,
discuss
future
prospects.
Biocon-jugation
chemistry
is
at
centerpiece
oligonucleotide
revolution,
significant
opportunities
exist
development
new
modification
chemistries,
mechanistic
studies
chemical-biology
interface,
translating
such
