Biomaterials Science, Journal Year: 2020, Volume and Issue: 9(4), P. 1153 - 1188
Published: Dec. 23, 2020
Restricted entry into the cells stands as an ultimate challenge for nanotherapeutics to exhibit their efficacy. Cell penetrating peptides can act a crucial assistant overcoming this challenge.
Language: Английский
Journal of Advanced Research, Journal Year: 2018, Volume and Issue: 15, P. 1 - 18
Published: June 25, 2018
Nonspecific distribution and uncontrollable release of drugs in conventional drug delivery systems (CDDSs) have led to the development smart nanocarrier-based systems, which are also known as Smart Drug Delivery Systems (SDDSs). SDDSs can deliver target sites with reduced dosage frequency a spatially controlled manner mitigate side effects experienced CDDSs. Chemotherapy is widely used treat cancer, second leading cause death worldwide. Site-specific keen interest an alternative chemotherapy. nanocarriers, nanoparticles carry drugs, at focus SDDSs. A system consists targeting mechanisms, stimulus techniques. This review highlights recent for number including liposomes, micelles, dendrimers, meso-porous silica nanoparticles, gold super paramagnetic iron-oxide carbon nanotubes, quantum dots. The nanocarriers described terms their structures, classification, synthesis degree smartness. Even though feature advantages over chemotherapy, there major concerns about toxicity nanocarriers; therefore, substantial study on biocompatibility has been reported. Finally, challenges future research scope field presented. It expected that this will be useful those who seeking new directions start studies delivery.
Language: Английский
Citations
856
ACS Applied Materials & Interfaces, Journal Year: 2020, Volume and Issue: 13(8), P. 9500 - 9519
Published: June 30, 2020
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have abilities to bind specific target molecules that rival those monoclonal antibodies. They attracting great attention in diverse clinical translations on account their various advantages, including prolonged storage life, little batch-to-batch differences, very low immunogenicity, and feasibility chemical modifications for enhancing stability, prolonging the half-life serum, targeted delivery. In this Review, we demonstrate emerging aptamer discovery technologies developing advanced techniques producing aptamers high performance consistently efficiently as well requiring less cost resources but offering chance success. Further, therapeutic applications agents, aptamer–drug conjugates, delivery materials comprehensively summarized.
Language: Английский
Citations
428
International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 18(10), P. 2142 - 2142
Published: Oct. 14, 2017
Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with high affinity and specificity. The process selecting an aptamer is called Systematic Evolution Ligands by Exponential Enrichment (SELEX). Thanks the inherit merits, aptamers have been used in a wide range applications, including disease diagnosis, targeted delivery agents therapeutic uses. To date, great achievements regarding selection, modifications application made. However, few aptamer-based products already successfully entered into clinical industrial use. Besides, it still challenge obtain more efficient way. Thus, important comprehensively review current shortage achievement aptamer-related technology. In this review, we first present limitations notable advances selection. Then, compare different methods kinetic characterization aptamers. We also discuss impetus developments
Language: Английский
Citations
401
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Nov. 3, 2023
Abstract Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading innovative developments in smart nanoparticles safer more effective therapy. In this review, we will highlight recent advancements including polymeric dendrimers, micelles, liposomes, protein cell membrane mesoporous silica gold iron oxide quantum dots, carbon nanotubes, black phosphorus, MOF others. We focus on their classification, structures, synthesis, intelligent features. These possess the ability various external internal stimuli, such enzymes, pH, temperature, optics, magnetism, making them systems. Additionally, review explore latest studies tumor targeting functionalizing surfaces with tumor-specific ligands like antibodies, peptides, transferrin, folic acid. also summarize different types options, small molecules, proteins, nucleic acids, even living cells, potential use While is promising, acknowledge challenges clinical prospects associated use. Finally, propose blueprint that involves artificial intelligence-powered treatment applications. By harnessing aims usher new era personalized therapy, providing patients individualized options.
Language: Английский
Citations
366
Molecules, Journal Year: 2020, Volume and Issue: 25(23), P. 5672 - 5672
Published: Dec. 1, 2020
In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used carrier, and only NP system currently approved by FDA for clinical use, owing to their advantageous physicochemical properties excellent biocompatibility. Recent advances in liposome technology have been focused on bioconjugation strategies improve loading, targeting, overall efficacy. this review, we highlight recent literature reports (covering last five years) enhancement of liposome-mediated delivery. These encompass improvement loading/incorporation specific targeting site interest/drug action. We conclude with a section highlighting role systems being evaluated use forward-looking discussion field liposomal
Language: Английский
Citations
216
Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9
Published: Feb. 6, 2018
There are currently a number of imaging techniques available for evaluating the morphology liposomes and other nanoparticles, with each having its own advantages disadvantages that should be considered when interpreting data. Controlling validating nanoparticles is key importance effective clinical translation liposomal formulations. physical characteristics determine their in vivo behaviour, including size, surface characteristics, lamellarity homogeneity. Despite great it generally not well characterized difficult to control. Appropriate provide important details regarding morphological used conjunction methods assess physicochemical parameters. In this review, we will discuss limitations evaluate
Language: Английский
Citations
198
Carbohydrate Polymers, Journal Year: 2018, Volume and Issue: 202, P. 382 - 396
Published: Sept. 6, 2018
Language: Английский
Citations
193
Biomedical Materials, Journal Year: 2021, Volume and Issue: 16(4), P. 042005 - 042005
Published: Feb. 12, 2021
Nanomaterials (NMs) have revolutionized multiple aspects of medicine by enabling novel sensing, diagnostic, and therapeutic approaches. Advancements in processing fabrication also allowed significant expansion the applications major classes NMs based on polymer, metal/metal oxide, carbon, liposome, or multi-scale macro-nano bulk materials. Concomitantly, concerns regarding nanotoxicity overall biocompatibility been raised. These involve putative negative effects both patients those subjected to occupational exposure during manufacturing. In this review, we describe current state testing including that are clinical use, trials, under development. We discuss cellular molecular interactions dictate their toxicity biocompatibility. Specifically, focus reciprocal between host proteins, lipids, sugars how these induce responses immune other cell types leading topical and/or systemic effects.
Language: Английский
Citations
160
ACS Nano, Journal Year: 2021, Volume and Issue: 15(2), P. 2099 - 2142
Published: Jan. 26, 2021
Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy at overcoming obstacles not readily surmounted by nonhybridized counterparts. Currently, are implemented gene therapy, drug delivery, phototherapy in addition to tissue regeneration, vaccines, antibacterials, biomolecule detection, imaging probes, theranostics. Though diverse, these can be classified according foundational inorganic/organic components, accessory moieties, architecture of hybridization. Within this Review, we begin providing a historical context the development biomedical before describing properties, synthesis, characterization component building blocks. Afterward, introduce architectures hybridization highlight recent nanosystem developments area application, emphasizing hybrids distinctive utility innovation. Finally, draw attention ongoing clinical trials recapping our discussion perspective on future field.
Language: Английский
Citations
147
Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8
Published: Dec. 1, 2021
Recently, owing to well-controlled release, enhanced distribution and increased permeability, nanocarriers used for alternative drug food-delivery strategies have received increasingly attentions. Nanocarriers attracted a large amount of interest as potential carriers various bioactive molecules multiple applications. Drug food-based delivery via polymeric-based lipid-based has been widely investigated. Nanocarriers, especially liposomes, are more in the area novel nano-pharmaceutical or design. Herein, we aimed discuss recent advancement different surface-engineered type, along with cutting-edge applications food nanomedicine highlight phytochemical nanocarrier. Additionally, safety concern was also highlighted.
Language: Английский
Citations
140