Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: Oct. 5, 2022
Polyploid
giant
cancer
cells
(PGCCs)
are
an
important
feature
of
cellular
atypia,
the
detailed
mechanisms
their
formation
and
function
remain
unclear.
PGCCs
were
previously
thought
to
be
derived
from
repeated
mitosis/cytokinesis
failure,
with
no
intrinsic
ability
proliferate
divide.
However,
recently,
have
been
confirmed
stem
cell
(CSC)-like
characteristics,
generate
progeny
through
asymmetric
division,
which
express
epithelial-mesenchymal
transition-related
markers
promote
invasion
migration.
The
can
attributed
multiple
stimulating
factors,
including
hypoxia,
chemotherapeutic
reagents,
radiation,
induce
PGCCs,
by
regulating
cycle
fusion-related
protein
expression.
properties
CSCs
suggest
that
induced
differentiate
into
non-tumor
cells,
produce
erythrocytes
composed
embryonic
hemoglobin,
a
high
affinity
for
oxygen,
thereby
allow
survival
severe
hypoxia.
number
is
associated
metastasis,
chemoradiotherapy
resistance,
recurrence
malignant
tumors.
Targeting
relevant
proteins
or
signaling
pathways
related
transdifferentiation
adipose
tissue
cartilage
in
may
provide
new
strategies
solid
tumor
therapy.
Cell Communication and Signaling,
Journal Year:
2020,
Volume and Issue:
18(1)
Published: April 7, 2020
Abstract
The
dynamic
interactions
of
cancer
cells
with
their
microenvironment
consisting
stromal
(cellular
part)
and
extracellular
matrix
(ECM)
components
(non-cellular)
is
essential
to
stimulate
the
heterogeneity
cell,
clonal
evolution
increase
multidrug
resistance
ending
in
cell
progression
metastasis.
reciprocal
cell-cell/ECM
interaction
tumor
hijacking
non-malignant
force
lose
function
acquire
new
phenotypes
that
promote
development
invasion
cells.
Understanding
underlying
cellular
molecular
mechanisms
governing
these
can
be
used
as
a
novel
strategy
indirectly
disrupt
interplay
contribute
efficient
safe
therapeutic
strategies
fight
cancer.
Furthermore,
tumor-derived
circulating
materials
also
diagnostic
tools
precisely
predict
monitor
outcome
therapy.
This
review
evaluates
such
potentials
various
advanced
models,
focus
on
3D
systems
well
lab-on-chip
devices.
Journal of Cellular Physiology,
Journal Year:
2018,
Volume and Issue:
234(6), P. 8381 - 8395
Published: Nov. 11, 2018
Abstract
Cancer
stem
cells
(CSCs)
are
self‐renewable
cell
types
that
identified
in
most
of
liquid
and
solid
cancers
contributed
to
tumor
onset,
expansion,
resistance,
recurrence,
metastasis
after
therapy.
CSCs
from
the
expression
surface
markers,
which
is
tumor‐type
dependent.
The
transition
between
with
cancer
other
non‐CSCs
occurs
cancers,
possibly
under
control
signals
microenvironment
(TME),
including
CSC
niche.
Cancer‐associated
fibroblasts
among
influential
for
promoting
both
differentiation
dedifferentiation
toward
attaining
a
CSC‐like
phenotype.
WNT/β‐catenin,
transforming
growth
factor‐β,
Hedgehog,
Notch
important
maintaining
self‐renewal
CSCs.
An
effective
therapeutic
strategy
relies
on
targeting
remove
possible
chance
relapse.
There
multiple
ways
target
CSCs,
immunotherapy,
hormone
therapy,
(mi)siRNA
delivery,
gene
knockout.
Such
approaches
can
be
designed
suppressing
stemness,
tumorigenic
cues
TME,
extrinsic
and/or
intrinsic
signaling,
hypoxia
or
cells.
Because
sharing
range
characteristics
normal
stem/progenitor
cells,
must
targeted
based
their
unique
markers
preferential
antigens.
Acta Pharmaceutica Sinica B,
Journal Year:
2020,
Volume and Issue:
11(1), P. 55 - 70
Published: Oct. 2, 2020
Cancer
stem
cells
(CSCs)
are
a
subpopulation
of
cancer
with
functions
similar
to
those
normal
cells.
Although
few
in
number,
they
capable
self-renewal,
unlimited
proliferation,
and
multi-directional
differentiation
potential.
In
addition,
CSCs
have
the
ability
escape
immune
surveillance.
Thus,
play
an
important
role
occurrence
development
tumors,
closely
related
tumor
invasion,
metastasis,
drug
resistance,
recurrence
after
treatment.
Therefore,
specific
targeting
may
improve
efficiency
therapy.
A
series
corresponding
promising
therapeutic
strategies
based
on
CSC
targeting,
such
as
niche,
signaling
pathways,
mitochondria,
currently
under
development.
Given
rapid
progression
this
field
nanotechnology,
delivery
systems
(DDSs)
for
increasingly
being
developed.
review,
we
summarize
advances
CSC-targeted
DDSs.
Furthermore,
highlight
latest
developmental
trends
through
main
line
process;
some
considerations
about
rationale,
advantages,
limitations
different
DDSs
therapies
were
discussed.
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(6), P. 784 - 784
Published: June 4, 2022
Cancer
is
one
of
the
main
causes
death
worldwide.
To
date,
and
despite
advances
in
conventional
treatment
options,
therapy
cancer
still
far
from
optimal
due
to
non-specific
systemic
biodistribution
antitumor
agents.
The
inadequate
drug
concentrations
at
tumor
site
led
an
increased
incidence
multiple
resistance
appearance
many
severe
undesirable
side
effects.
Nanotechnology,
through
development
nanoscale-based
pharmaceuticals,
has
emerged
provide
new
innovative
drugs
overcome
these
limitations.
In
this
review,
we
overview
approved
nanomedicine
for
rationale
behind
their
designs
applications.
We
also
highlight
approaches
that
are
currently
under
investigation
perspectives
challenges
nanopharmaceuticals,
focusing
on
microenvironment
disseminate
cells
as
most
attractive
effective
strategies
treatments.
Frontiers in Cell and Developmental Biology,
Journal Year:
2020,
Volume and Issue:
8
Published: May 19, 2020
Flexibility
in
the
exchange
of
genetic
material
takes
place
between
different
organisms
same
or
species.
This
phenomenon
is
known
to
play
a
key
role
genetic,
physiological,
and
ecological
performance
host.
Exchange
materials
can
cause
both
beneficial
and/or
adverse
biological
consequences.
Horizontal
gene
transfer
(HGT)
lateral
(LGT)
as
general
mechanism
leads
biodiversity
innovations
nature.
HGT
mediators
are
one
engineering
tools
used
for
selective
introduction
desired
changes
genome
gene/cell
therapy
purposes.
HGT,
however,
crucial
development,
emergence,
recurrence
various
human-related
diseases,
such
cancer,
genetic-,
metabolic-,
neurodegenerative
disorders
negatively
affect
therapeutic
outcome
by
promoting
resistant
forms
disrupting
editing
toolkits.
Because
importance
its
vital
physio-
pathological
roles,
here
variety
mechanisms
reviewed,
ranging
from
extracellular
vesicles
(EVs)
nanotubes
prokaryotes
cell-free
DNA
apoptotic
bodies
eukaryotes.
Next,
we
argue
that
plays
development
useful
features
states
associated
with
emerging
recurrent
disease.
A
better
understanding
their
genome-altering
effects/potentials
may
pave
way
more
effective
diagnostic
regimes.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 12, 2024
Abstract
Cancer
treatment
faces
many
hurdles
and
resistance
is
one
among
them.
Anti-cancer
strategies
are
evolving
due
to
innate
acquired
capacity,
governed
by
genetic,
epigenetic,
proteomic,
metabolic,
or
microenvironmental
cues
that
ultimately
enable
selected
cancer
cells
survive
progress
under
unfavorable
conditions.
Although
the
mechanism
of
drug
being
widely
studied
generate
new
target-based
drugs
with
better
potency
than
existing
ones.
However,
broader
flexibility
in
resistance,
advanced
therapeutic
options
efficacy
need
be
explored.
Combination
therapy
an
alternative
a
success
rate
though
risk
amplified
side
effects
commonplace.
Moreover,
recent
groundbreaking
precision
immune
ways
overcome
has
revolutionized
anticancer
greater
extent
only
limitation
individual-specific
needs
further
attention.
This
review
will
focus
on
challenges
opted
withstand
current
therapies
at
molecular
level
also
highlights
emerging
-like
immunological,
stem
cell-based
may
prove
have
potential
challenge
problem
resistance.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(9), P. 10875 - 10885
Published: Feb. 22, 2024
Chemotherapy
is
widely
used
for
cancer
therapy;
however,
its
efficacy
limited
due
to
poor
targeting
specificity
and
severe
side
effects.
Currently,
the
next
generations
of
delivery
systems
with
multitasking
potential
have
attracted
significant
attention
therapy.
This
study
reports
on
design
synthesis
a
multifunctional
nanoplatform
based
niosomes
(NIO)
coloaded
paclitaxel
(PTX),
chemotherapeutic
drug
commonly
treat
breast
cancer,
sodium
oxamate
(SO),
glycolytic
inhibitor
enhance
cytotoxicity
anticancer
drug,
along
quantum
dots
(QD)
as
bioimaging
agents,
hyaluronic
acid
(HA)
coating
active
targeting.
HN@QPS
nanoparticles
size
∼150
nm
surface
charge
-39.9
mV
more
than
90%
EE
PTX
were
synthesized.
Codelivery
SO
remarkably
boosted
effects
PTX,
achieving
IC
