Chinese Chemical Letters, Journal Year: 2021, Volume and Issue: 33(4), P. 1927 - 1932
Published: Nov. 24, 2021
Language: Английский
Biomaterials, Journal Year: 2022, Volume and Issue: 293, P. 121975 - 121975
Published: Dec. 20, 2022
Language: Английский
Citations
61
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: Nov. 24, 2022
Abstract Sulfur bonds, especially trisulfide bond, have been found to ameliorate the self-assembly stability of homodimeric prodrug nanoassemblies and could trigger sensitive reduction-responsive release active drugs. However, antitumor efficacy with single reduction-responsivity may be restricted due heterogeneous tumor redox microenvironment. Herein, we replace middle sulfur atom bond an oxidizing tellurium or selenium construct dual-responsive sulfur-tellurium-sulfur sulfur-selenium-sulfur hybrid chalcogen bonds. The exhibit ultrahigh dual-responsivity both oxidation reduction conditions, which effectively address Moreover, promotes prodrugs by providing strong intermolecular forces sufficient steric hindrance. above advantages bridged result in improved docetaxel satisfactory safety. exploration bonds drug delivery deepened insight into development prodrug-based chemotherapy heterogeneity, thus enriching design theory nanomedicines.
Language: Английский
Citations
52
Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6652 - 6703
Published: Jan. 1, 2022
Degradable polyprodrugs are developed to increase therapeutic properties of drugs and reduce detrimental side effects.
Language: Английский
Citations
51
Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 135160 - 135160
Published: Feb. 9, 2022
Language: Английский
Citations
49
Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(4)
Published: Nov. 9, 2022
Abstract Safe and effective strategies are urgently needed to fight against the life‐threatening diseases of various cancers. However, traditional therapeutic modalities, such as radiotherapy, chemotherapy surgery, exhibit suboptimal efficacy for malignant tumors owing serious side effects, drug resistance even relapse. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), emerging localized tumor inhibition, which can produce a large amount reactive oxygen species (ROS) or elevate temperature initiate cell death by non‐invasive irradiation. In consideration poor bioavailability phototherapy agents (PTAs), lots delivery systems have been developed enhance targeted delivery. Nevertheless, carriers inevitably bring biosafety concerns on account their metabolism, degradation, accumulation. Of note, carrier‐free nanomedicine attracts great attention clinical translation with synergistic antitumor effect, is characterized high loading, simplified synthetic method good biocompatibility. this review, latest advances nanomedicines summarized, may provide new paradigm future development precision therapy.
Language: Английский
Citations
49
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 102 - 122
Published: Sept. 20, 2022
Language: Английский
Citations
46
DNA repair, Journal Year: 2023, Volume and Issue: 123, P. 103449 - 103449
Published: Jan. 14, 2023
Language: Английский
Citations
35
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(8), P. 3252 - 3276
Published: March 5, 2023
Chemotherapy has occupied the critical position in cancer therapy, especially towards post-operative, advanced, recurrent, and metastatic tumors. Paclitaxel (PTX)-based formulations have been widely used clinical practice, while therapeutic effect is far from satisfied due to off-target toxicity drug resistance. The caseless multi-components make preparation technology complicated aggravate concerns with excipients-associated toxicity. self-assembled PTX nanoparticles possess a high content could incorporate various functional molecules for enhancing index. In this work, we summarize self-assembly strategy diverse nanodrugs of PTX. Then, advancement tumor emphasis on mono-chemotherapy, combinational theranostics, outlined. Finally, challenges potential improvements briefly spotlighted.
Language: Английский
Citations
29
Aggregate, Journal Year: 2023, Volume and Issue: 5(1)
Published: Oct. 12, 2023
Abstract Nowadays, cancer has become the leading cause of death worldwide, driving need for effective therapeutics to improve patient prognosis. Photodynamic therapy (PDT) been widely applied as an antitumor modality, owing its minimal invasiveness, localized tumor damage, and high safety profile. However, efficacy is limited by poor stability photosensitizers, inadequate accumulation, a complex microenvironment. To overcome these challenges, extensive endeavors have made explore co‐assembly used photosensitizer chlorin e6 (Ce6) with various functional small molecules enhance pharmacodynamic activity. This review provides comprehensive overview current studies on Ce6‐based nanoparticles PDT precise delivery molecules. The self‐assembly mechanism will be discussed in detail, focus potential strategies combinational PDT.
Language: Английский
Citations
25
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(32), P. 22675 - 22688
Published: Aug. 1, 2024
Redox-responsive homodimer prodrug nanoassemblies (RHPNs) have emerged as a significant technology for overcoming chemotherapeutical limitations due to their high drug-loading capacity, low excipient-associated toxicity, and straightforward preparation method. Previous studies indicated that α-position disulfide bond bridged RHPNs exhibited rapid drug release rates but unsatisfactory assembly stability. In contrast, γ-disulfide showed better stability rates. Therefore, designing chemical linkages ensure both stable remains challenging. To address this paradox of in RHPNs, we developed carbon-spaced double-disulfide (CSDD)-bridged (CSDD-RHPNs) with two carbon-spaces. Pilot CSDD-RHPNs carbon-spaces enhanced stability, reduction-responsive release, improved selective toxicity compared α-/γ-position single RHPNs. Based on these findings, four six were designed further investigate the properties CSDD-RHPNs. These excellent ability, safety, prolonged circulation. Particularly, displayed best antitumor efficacy 4T1 B16–F10 tumor-bearing mice. CSDD offer novel perspectives rational design potentially regarding contradictory ability rate.
Language: Английский
Citations
9