Science Advances,
Journal Year:
2023,
Volume and Issue:
9(16)
Published: April 19, 2023
Intracerebral
vector
delivery
in
nonhuman
primates
has
been
a
major
challenge.
We
report
successful
blood-brain
barrier
opening
and
focal
of
adeno-associated
virus
serotype
9
vectors
into
brain
regions
involved
Parkinson’s
disease
using
low-intensity
focus
ultrasound
adult
macaque
monkeys.
Openings
were
well
tolerated
with
generally
no
associated
abnormal
magnetic
resonance
imaging
signals.
Neuronal
green
fluorescent
protein
expression
was
observed
specifically
confirmed
opening.
Similar
openings
safely
demonstrated
three
patients
disease.
In
these
one
monkey,
followed
by
18
F-Choline
uptake
the
putamen
midbrain
based
on
positron
emission
tomography.
This
indicates
cellular
binding
molecules
that
otherwise
would
not
enter
parenchyma.
The
less-invasive
nature
this
methodology
could
facilitate
viral
for
gene
therapy
might
allow
early
repeated
interventions
to
treat
neurodegenerative
disorders.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
123(2), P. 834 - 873
Published: Aug. 5, 2022
Biomaterials
with
the
ability
to
self-heal
and
recover
their
structural
integrity
offer
many
advantages
for
applications
in
biomedicine.
The
past
decade
has
witnessed
rapid
emergence
of
a
new
class
self-healing
biomaterials
commonly
termed
injectable,
or
printable
context
3D
printing.
These
injectable
biomaterials,
mostly
hydrogels
other
soft
condensed
matter
based
on
reversible
chemistry,
are
able
temporarily
fluidize
under
shear
stress
subsequently
original
mechanical
properties.
Self-healing
distinct
compared
traditional
biomaterials.
Most
notably,
they
can
be
administered
locally
targeted
minimally
invasive
manner
through
narrow
syringe
without
need
surgery.
Their
moldability
allows
patient-specific
intervention
shows
great
prospects
personalized
medicine.
Injected
facilitate
tissue
regeneration
multiple
ways
owing
viscoelastic
diffusive
nature,
ranging
from
simple
support,
spatiotemporally
controlled
delivery
cells
therapeutics,
local
recruitment
modulation
host
promote
regeneration.
Consequently,
have
been
at
forefront
cutting-edge
strategies.
This
study
provides
critical
review
current
state
As
key
challenges
toward
further
maturation
this
exciting
research
field,
we
identify
(i)
trade-off
between
injectability
vs
physical
stability,
(ii)
lack
consensus
rheological
characterization
quantitative
benchmarks
hydrogels,
particularly
regarding
capillary
flow
syringes,
(iii)
practical
limitations
translation
therapeutically
effective
formulations
specific
tissues.
Hence,
here
chemical
design
strategies
provide
guide
analysis,
showcase
applicability
various
tissues
printing
complex
organoids.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 1, 2024
Abstract
Combining
existing
drug
therapy
is
essential
in
developing
new
therapeutic
agents
disease
prevention
and
treatment.
In
preclinical
investigations,
combined
effect
of
certain
known
drugs
has
been
well
established
treating
extensive
human
diseases.
Attributed
to
synergistic
effects
by
targeting
various
pathways
advantages,
such
as
reduced
administration
dose,
decreased
toxicity,
alleviated
resistance,
combinatorial
treatment
now
being
pursued
delivering
combat
major
clinical
illnesses,
cancer,
atherosclerosis,
pulmonary
hypertension,
myocarditis,
rheumatoid
arthritis,
inflammatory
bowel
disease,
metabolic
disorders
neurodegenerative
Combinatorial
involves
combining
or
co-delivering
two
more
for
a
specific
disease.
Nanoparticle
(NP)-mediated
delivery
systems,
i.e.,
liposomal
NPs,
polymeric
NPs
nanocrystals,
are
great
interest
wide
range
due
targeted
delivery,
extended
release,
higher
stability
avoid
rapid
clearance
at
infected
areas.
This
review
summarizes
targets
diseases,
clinically
approved
combinations
the
development
multifunctional
emphasizes
strategies
based
on
severe
Ultimately,
we
discuss
challenging
NP-codelivery
translation
provide
potential
approaches
address
limitations.
offers
comprehensive
overview
recent
cutting-edge
NP-mediated
combination
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(20)
Published: March 27, 2023
Abstract
In
recent
years,
the
development
of
hyaluronic
acid
or
hyaluronan
(HA)
based
scaffolds,
medical
devices,
bioconjugate
systems
have
expanded
into
a
broad
range
research
and
clinical
applications.
Research
findings
over
last
two
decades
suggest
that
abundance
HA
in
most
mammalian
tissues
with
distinctive
biological
roles
chemical
simplicity
for
modifications
made
it
an
attractive
material
rapidly
growing
global
market.
Besides
its
use
as
native
forms,
has
received
much
interest
on
so‐called
“HA‐bioconjugates”
“modified‐HA
systems”.
this
review,
importance
HA,
underlying
rationale
approaches,
various
advancements
derivatives
their
potential
physicochemical,
pharmacological
advantages
are
summarized.
This
review
also
highlights
current
emerging
HA‐based
conjugates
small
molecules,
macromolecules,
crosslinked
systems,
surface
coating
strategies
implications,
including
potentials
key
challenges
discussed
detail.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
171, P. 116113 - 116113
Published: Jan. 5, 2024
Glioblastoma
multiforme
(GBM)
is
the
most
common
primary
malignant
brain
tumor,
characterized
by
high
heterogeneity,
strong
invasiveness,
poor
prognosis,
and
a
low
survival
rate.
A
broad
range
of
nanoparticles
have
been
recently
developed
as
drug
delivery
systems
for
GBM
therapy
owing
to
their
inherent
size
effect
ability
cross
blood-brain
barrier
(BBB).
Lipid-based
(LBNPs),
such
liposomes,
solid
lipid
NPs
(SLNs),
nano-structured
carriers
(NLCs),
emerged
promising
system
treatment
because
unique
size,
surface
modification
possibilities,
proven
bio-safety.
In
this
review,
main
challenges
current
clinical
strategies
on
how
novel
LBNPs
overcome
them
were
explored.
The
application
progress
LBNP-based
in
chemotherapy,
immunotherapy,
gene
recent
years
systematically
reviewed,
prospect
was
discussed.
