Transethosomes: A Comprehensive Review of Ultra-Deformable Vesicular Systems for Enhanced Transdermal Drug Delivery

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 17, 2025

Language: Английский

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Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.

Language: Английский

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Bacterial cellulose in transdermal drug delivery systems: Expanding horizons in multi-scale therapeutics and patient-centric approach

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125254 - 125254

Published: Jan. 1, 2025

Language: Английский

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The application of corticosteroids for pathological scar prevention and treatment: current review and update

Burns & Trauma, Journal Year: 2023, Volume and Issue: 11

Published: Jan. 1, 2023

The prevention and treatment of pathological scars remain challenging. Corticosteroids are the mainstay drugs in clinical scar as they effectively induce regression improve pruritus pain. Currently, intralesional injections corticosteroids widely used practice. These require professional medical manipulation; however, significant accompanying injection pain, repetition adverse effects, such skin atrophy, pigmentation telangiectasia, make this modality an unpleasant experience for patients. Transdermal administration is, therefore, a promising non-invasive easy-to-use method corticosteroid treatment. In review, we first summarize mechanisms action treatment; then, discuss current developments progress transdermal delivery systems corticosteroids, well their corresponding advantages disadvantages.

Language: Английский

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Oxymatrine-fatty acid deep eutectic solvents as novel penetration enhancers for transdermal drug delivery: Formation mechanism and enhancing effect

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 637, P. 122880 - 122880

Published: March 21, 2023

Language: Английский

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Polysaccharide hydrogel platforms as suitable carriers of liposomes and extracellular vesicles for dermal applications

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115028 - 115028

Published: July 28, 2023

Lipid-based nanocarriers have been extensively investigated for their application in drug delivery. Particularly, liposomes are now clinically established treating various diseases such as fungal infections. In contrast, extracellular vesicles (EVs) - small cell-derived nanoparticles involved cellular communication just recently sparked interest carriers but development is still at the preclinical level. To drive this further, methods and technologies exploited context of liposome research should be applied domain EVs to facilitate accelerate clinical translation. One crucial steps EV-based therapeutics designing them proper dosage forms specific applications. This review offers a comprehensive overview state-of-the-art polysaccharide-based hydrogel platforms designed artificial natural with delivery skin. We discuss physicochemical biological properties try create sound basis optimization EV-embedded hydrogels versatile therapeutic avenues.

Language: Английский

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Solubilization techniques used for poorly water-soluble drugs

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716

Published: Sept. 2, 2024

About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.

Language: Английский

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Microneedle Delivery Platform Integrated with Codelivery Nanoliposomes for Effective and Safe Androgenetic Alopecia Treatment

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 15701 - 15717

Published: March 20, 2024

Although topical application of minoxidil is a widely used, FDA-approved therapy for androgenetic alopecia (AGA) treatment, it suffers from low bioavailability, the requirement frequent long-term use, and side effects. With similar structure as minoxidil, kopexil kopyrrol are less toxic have been commercialized, but show an inferior hair regeneration effect compared to minoxidil. Herein, we developed hyaluronic acid (HA)-based dissolvable microneedles (MNs) delivery platform integrated with coencapsulated nanoliposomes (KK-NLPs) effectively safely treat AGA. Facilitated by MNs, encapsulated KK-NLPs performed efficient skin penetration enhanced cellular internalization into human dermal papilla cells. Furthermore, within target cells, codelivered synergistic effects orchestrating upregulation in expression Ki67, β-catenin, vascular endothelial growth factor (VEGF), CD31. These molecular responses collectively foster cell proliferation, migration, antioxidative effects, thereby facilitating expedited progression follicles (HFs) anagen phase promoting peripheral angiogenesis. Notably, KK-NLPs-integrated MNs treatment group exhibits noteworthy vivo, identical or superior therapeutic at much lower dosage than that results suggest great potential this codelivery nanoliposomes-integrated AGA safe way.

Language: Английский

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Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115198 - 115198

Published: Feb. 9, 2024

Language: Английский

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Incorporating surfactants into PCL microneedles for sustained release of a hydrophilic model drug

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 652, P. 123826 - 123826

Published: Jan. 21, 2024

Language: Английский

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