Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114825 - 114825
Published: April 18, 2023
Language: Английский
Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 159, P. 110625 - 110625
Published: Sept. 10, 2024
Language: Английский
Citations
13
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 332, P. 103270 - 103270
Published: Aug. 6, 2024
Language: Английский
Citations
12
Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 144 - 144
Published: Jan. 8, 2025
Probiotics are an essential dietary supplement for intestinal flora balance, inhibition of pathogenic bacteria and immune regulation. However, probiotic inactivation during gastrointestinal transportation remains a big challenge oral administration. Hence, delivery systems (ODSs) based on polysaccharides have been constructed to protect probiotics from harsh environments. Cellulose, chitosan, alginate their derivates used form protective layer probiotics. This review summarizes the superiority application in forming layers Meanwhile, ODS processes including extrusion, emulsion spray drying also summarized. The preparation technique mechanism, microparticle formation process especially role serve overviewed. Lastly, need cell viability retention dehydration construction core-shell microparticles is emphasized this review.
Language: Английский
Citations
2
Food Hydrocolloids, Journal Year: 2025, Volume and Issue: 163, P. 111060 - 111060
Published: Jan. 7, 2025
Language: Английский
Citations
1
Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 1, 2025
Abstract Probiotics are highly regarded for their multiple functions, such as regulating gut health, enhancing the immune system, and preventing chronic diseases. However, stability in harsh environments targeted release remain significant challenges. Therefore, exploring effective protection delivery strategies to ensure of probiotics is critically important. Polysaccharides, known non‐toxicity, excellent biocompatibility, superior biodegradability, show broad prospects probiotic by forming physical barriers protect probiotics. Particularly, polysaccharide‐based gels (PBGs), with unique “spider‐web” like structure, capture probiotics, significantly efficacy. This review discusses common polysaccharides used PBG preparation, classification synthesis food applications, advantages PBGs systems. Despite potential, challenges inconsistent gel properties need improved remain. Future research should focus on developing novel materials higher biodegradability mechanical strength, optimizing physicochemical cross‐linking methods, well designing multilayered structures more precise control. Additionally, co‐delivery prebiotics, active ingredients, or multi‐strain systems could further enhance efficacy delivery.
Language: Английский
Citations
1
Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 64, P. 223 - 235
Published: Nov. 26, 2023
The microbiota inhabits the epithelial surfaces of hosts, which influences physiological functions from helping digest food and acquiring nutrition to regulate metabolism shaping host immunity. With deep insight into microbiota, an increasing amount research reveals that it is also involved in initiation progression cancer. Intriguingly, gut can mediate biotransformation drugs, thereby altering their bioavailability, bioactivity, or toxicity. Review review aims elaborate on role microbial metabolites efficacy adverse effects chemotherapeutics. Furthermore, we discuss clinical potential various ways harness for cancer chemotherapy. Key Scientific Concepts Recent evidence shows modulates toxicity chemotherapy agents, leading diverse responses Thereinto, targeting improve diminish chemotherapeutic drugs may be a promising strategy tumor treatment.
Language: Английский
Citations
19
Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(3)
Published: April 10, 2024
Abstract Adequate intake of live probiotics is beneficial to human health and wellbeing because they can help treat or prevent a variety conditions. However, the viability reduced by harsh environments experience during passage through gastrointestinal tract (GIT). Consequently, oral delivery viable significant challenge. Probiotic encapsulation provides potential solution this problem. production methods used create conventional technologies often damage probiotics. Moreover, systems produced do not have required physicochemical attributes robustness for food applications. Single‐cell based on forming protective coating around single probiotic cell. These coatings may be biofilms biopolymer layers designed protect from environment, enhance their colonization, introduce additional functions. This article reviews factors affecting probiotics, analyses shortcomings existing technologies, highlights advantages single‐cell encapsulation. It also various approaches available including implementation characteristics produce. In addition, mechanisms which improve bioavailability benefits are described. benefits, limitations, safety issues technology applications in beverages analyzed. Finally, future directions challenges widespread adoption highlighted.
Language: Английский
Citations
8
LWT, Journal Year: 2024, Volume and Issue: 199, P. 116100 - 116100
Published: April 16, 2024
In this study, soyasaponin (Ssa), corn oil, and soybean protein isolate (SPI) were used to prepare a water-in-oil-in-water (W/O/W) double emulsion system that can protect Lactobacillus plantarum (L.P) in the upper gastrointestinal tract for delivery small intestine colon. Incorporating different amounts of L.P (0.1–0.6% (w/v)) W/O/W caused viscoelastic modulus droplet size L.P-embedded change, transformed from non-Newtonian fluid "solid-like" gel. These results revealed encapsulation led significantly improved stability emulsion. addition, concentrations had effects on survival rate simulated digestive fluids, after vitro digestion, was naturally delivered stomach into intestines. The optimal concentration obtaining stable found be 0.3%, encapsulated as high 78.96% 1 h. Thus, choosing an appropriate amount crucial. effectively maintained viability successfully it
Language: Английский
Citations
8
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 652, P. 123810 - 123810
Published: Jan. 18, 2024
Language: Английский
Citations
7
Designed Monomers & Polymers, Journal Year: 2024, Volume and Issue: 28(1), P. 1 - 34
Published: Dec. 31, 2024
This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.
Language: Английский
Citations
7