Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117277 - 117277

Published: Aug. 9, 2024

Language: Английский

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Revolutionizing Alzheimer's treatment: Harnessing human serum albumin for targeted drug delivery and therapy advancements

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102379 - 102379

Published: June 18, 2024

Language: Английский

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Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 336 - 357

Published: July 24, 2024

Alzheimer's disease (AD) is a complex neurodegenerative condition characterized by metabolic imbalances and neuroinflammation, posing formidable challenge in medicine due to the lack of effective treatments. Despite considerable research efforts, cure for AD remains elusive, with current therapies primarily focused on symptom management rather than addressing disease's underlying causes. This study initially discerned, through Mendelian randomization analysis that elevating pantothenate levels significantly contributes prophylaxis disease. We explore therapeutic potential encapsulated liposomes (Pan@TRF@Liposome NPs), targeting modulation CRM1-mediated PKM2 nuclear translocation, critical mechanism pathology. Additionally, we investigate synergistic effects exercise, proposing combined approach treatment. Exercise-induced alterations share significant similarities those associated dementia, suggesting complementary effect. The Pan@TRF@Liposome NPs exhibit notable biocompatibility, showing no liver or kidney toxicity vivo, while demonstrating stability effectiveness modulating thereby reducing neuroinflammation neuronal apoptosis. treatment exercise NP administration an animal model leads improved neurofunctional outcomes cognitive performance. These findings highlight nanoparticles' role as modulators implications mitigating Together this dual-modality could offer new avenues enhancing performance AD, marking promising step forward developing strategies challenging disorder.

Language: Английский

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Assessment of Neuroprotective Potential of Cuscuta reflexa in Aluminium Chloride-Induced Experimental Model of Alzheimer’s Disease: In Vitro and In Vivo Studies

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127612 - 127612

Published: Feb. 1, 2025

Language: Английский

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Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

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Cornus officinalis Sieb. attenuates Aβ25-35-induced mitochondrial damage and neuroinflammation in mice by modulating the ERK pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155709 - 155709

Published: May 3, 2024

Language: Английский

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Unlocking the Potential: Semaglutide’s Impact on Alzheimer’s and Parkinson’s Disease in Animal Models

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(6), P. 5929 - 5949

Published: June 13, 2024

Semaglutide (SEM), a glucagon-like peptide-1 receptor agonist, has garnered increasing interest for its potential therapeutic effects in neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s (PD). This review provides comprehensive description of SEM’s mechanism action preclinical studies these debilitating conditions. In animal models AD, SEM proved beneficial on multiple pathological hallmarks the disease. administration been associated with reductions amyloid-beta plaque deposition mitigation neuroinflammation. Moreover, treatment shown to ameliorate behavioral deficits related anxiety social interaction. SEM-treated animals exhibit improvements spatial learning memory retention tasks, evidenced by enhanced performance maze navigation tests novel object recognition assays. Similarly, PD, demonstrated promising neuroprotective through various mechanisms. These include modulation neuroinflammation, enhancement mitochondrial function, promotion neurogenesis. Additionally, improve motor function dopaminergic neuronal loss, offering disease-modifying strategies. Overall, accumulating evidence from suggests that holds promise approach AD PD. Further research is warranted elucidate underlying mechanisms translate findings into clinical applications devastating disorders.

Language: Английский

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Evolution of lipid nanoparticles as charioteers of Alzheimer's disease therapeutics

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102442 - 102442

Published: Sept. 23, 2024

Language: Английский

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Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders

Neuroscience, Journal Year: 2024, Volume and Issue: 565, P. 63 - 79

Published: Nov. 26, 2024

Language: Английский

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Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier

Biomimetics, Journal Year: 2025, Volume and Issue: 10(1), P. 25 - 25

Published: Jan. 3, 2025

Meningitis is the acute or chronic inflammation of protective membranes, surrounding brain and spinal cord, this inflammatory process spreads throughout subarachnoid space. The traditional drug delivery methods pose a disadvantage in limiting capacity crossing blood–brain barrier (BBB) to reach central nervous system (CNS). Hence, it imperative develop novel approaches that can overcome these constraints offer efficient therapy for meningitis. Nanoparticle (NP)-based therapeutic have potential address limitations such as penetrating BBB achieving targeted release specific cells tissues. This review highlights recent advancements nanotechnology-based approaches, functionalized polymeric nanoparticles, solid lipid nanoparticles (SLNs), nanostructured carriers, nanoemulsions, liposomes, transferosomes, metallic NPs treatment Recently, bionics has emerged next-generation technology development ideas from biological principles, structures, interactions neurological neuroinfectious diseases. Despite their potential, more studies are needed ensure safety efficacy NP-based systems focusing on critical aspects toxicity, immunogenicity, pharmacokinetics. Therefore, addresses current strategies innovative nanoparticle discusses future directions meningitis therapies.

Language: Английский

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