Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 13, 2024
The
emerging
extracellular
vesicles
technologies
is
an
advanced
therapeutic
approach
showing
promising
potential
for
addressing
inflammatory
diseases.
These
techniques
have
been
proven
to
positive
effects
on
immune
modulation
and
anti-inflammatory
responses.
With
these
advancements,
a
comprehensive
review
update
the
role
of
in
diseases
become
timely.
This
aims
summarize
research
progress
vesicle
such
as
plant-derived
vesicles,
milk-derived
mesenchymal
stem
cell-derived
macrophage-derived
etc.,
treatment
It
elucidates
their
significance
regulating
inflammation,
promoting
tissue
repair,
treating
goal
provide
insights
future
this
field,
fostering
application
development
technology
Molecules,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3863 - 3863
Published: May 3, 2023
Ginseng,
a
medicinal
plant
of
the
genus
Panax,
boasts
rich
historical
record
usage
that
dates
back
to
Paleolithic
period.
This
botanical
is
extensively
acknowledged
and
consumed
in
Eastern
countries
for
its
therapeutic
properties,
and,
Western
countries,
it
becoming
increasingly
popular
as
remedy
fatigue
asthenia.
review
provides
an
update
on
current
research
pertaining
ginseng
isolated
compounds,
namely,
ginsenosides
polysaccharides.
The
primary
focus
three
crucial
pharmacological
activities,
immunomodulation,
anti-inflammatory,
anti-cancer
effects.
encompasses
studies
both
compounds
various
extracts
obtained
from
root,
leaves,
berries.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(5)
Published: Oct. 1, 2023
Inflammasomes
are
a
group
of
protein
complex
located
in
cytoplasm
and
assemble
response
to
wide
variety
pathogen-associated
molecule
patterns,
damage-associated
cellular
stress.
Generally,
the
activation
inflammasomes
will
lead
maturation
proinflammatory
cytokines
pyroptotic
cell
death,
both
associated
with
inflammatory
cascade
amplification.
A
sensor
protein,
an
adaptor,
procaspase
interact
through
their
functional
domains
compose
one
subunit
inflammasome
complex.
Under
physiological
conditions,
functions
against
pathogen
infection
endogenous
dangers
including
mtROS,
mtDNA,
so
on,
while
dysregulation
its
can
unwanted
results.
In
recent
years,
advances
have
been
made
clarify
mechanisms
activation,
structural
details
them
(negative/positive)
multiple
disease
models
animal
human.
The
range
stimuli
makes
function
diverse
Here,
we
review
structure,
biological
functions,
therapeutic
targets
inflammasomes,
highlight
NLRP3,
NLRC4,
AIM2
which
most
well
studied.
conclusion,
this
focuses
on
process,
structure
well-studied
summarizing
predicting
approaches
for
treatment
prevention
as
target.
We
aim
provide
fresh
insight
into
new
solutions
challenges
field.
Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
20(2)
Published: Jan. 14, 2023
Adverse
cardiac
remodeling
may
lead
to
the
development
and
progression
of
heart
failure,
which
is
lack
effective
clinical
treatment.
Ginsenoside
Rg1
(GRg1),
a
primary
ingredient
Panax
ginseng,
protects
against
diverse
cardiovascular
disease,
but
its
effects
on
remain
unclear.
Thus,
we
investigated
protective
effect
mechanism
GRg1
after
myocardial
infarction.
significantly
ameliorated
in
mice
with
left
anterior
descending
coronary
artery
ligation,
reflected
by
reduced
ventricular
dilation
decreased
fibrosis,
accompanied
improved
function.
Mechanistically,
considerably
increased
mitophagosomes
formation,
mitochondria
damage,
enhanced
SIRT1/PINK1/Parkin-mediated
mitophagy
during
remodeling.
Consistently,
cell
viability
attenuated
apoptosis
fibrotic
responses
H2
O2
-treated
H9c2
cells
promoting
SIRT1/PINK1/Parkin
axis.
Furthermore,
SIRT1-specific
inhibitor
(EX527)
or
use
small
interfering
RNA
Parkin
abolished
vitro.
These
findings
reveal
novel
alleviating
via
enhancing
mitophagy.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(4), P. 999 - 999
Published: March 23, 2023
Increasingly
prevalent
acute
and
chronic
human
brain
diseases
are
scourges
for
the
elderly.
Besides
lack
of
therapies,
these
ailments
share
a
neuroinflammation
that
is
triggered/sustained
by
different
innate
immunity-related
protein
oligomers
called
inflammasomes.
Relevant
players
such
as
microglia/monocytes
typically
exhibit
strong
NLRP3
inflammasome
activation.
Hence
idea
suppression
might
solve
neurodegenerative
ailments.
Here
we
review
recent
Literature
about
this
topic.
First,
update
conditions
mechanisms,
including
RNAs,
extracellular
vesicles/exosomes,
endogenous
compounds,
ethnic/pharmacological
agents/extracts
regulating
function.
Second,
pinpoint
NLRP3-activating
mechanisms
known
inhibition
effects
in
(ischemia,
stroke,
hemorrhage),
(Alzheimer’s
disease,
Parkinson’s
Huntington’s
MS,
ALS),
virus-induced
(Zika,
SARS-CoV-2,
others)
diseases.
The
available
data
show
(i)
disease-specific
divergent
activate
(mainly
animal)
brains
NLRP3;
(ii)
no
evidence
proves
modifies
(yet
ad
hoc
trials
ongoing);
(iii)
findings
exclude
concurrently
activated
other-than-NLRP3
inflammasomes
functionally
replace
inhibited
NLRP3.
Finally,
highlight
among
causes
persistent
therapies
species
difference
problem
disease
models
preference
symptomatic
over
etiologic
therapeutic
approaches.
Therefore,
posit
neural
cell-based
could
drive
etiological,
pathogenetic,
advances,
NLRP3’s
other
inflammasomes’
regulation,
while
minimizing
failure
risks
candidate
drug
trials.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(4), P. 2007 - 2022
Published: Feb. 19, 2024
Abstract
This
review
highlights
the
increasing
interest
in
one
of
natural
compounds
called
saponins,
for
their
potential
therapeutic
applications
addressing
inflammation
which
is
a
key
factor
various
chronic
diseases.
It
delves
into
molecular
mechanisms
responsible
anti‐inflammatory
effects
these
amphiphilic
compounds,
prevalent
plant‐based
foods
and
marine
organisms.
Their
structures
vary
with
soap‐like
properties
influencing
historical
uses
traditional
medicine
sparking
renewed
scientific
interest.
Recent
research
focuses
on
inflammatory
diseases,
unveiling
actions
such
as
NF‐κB
MAPK
pathway
regulation
COX/LOX
enzyme
inhibition.
Saponin‐containing
sources
like
Panax
ginseng
soybeans
suggest
novel
therapies.
The
explores
emerging
role
shaping
gut
microbiome,
composition
activity,
contributing
to
effects.
Specific
examples,
notoginseng
Gynostemma
pentaphyllum
,
illustrate
intricate
relationship
between
collective
impact
immune
metabolic
health.
Despite
promising
findings,
emphasizes
need
further
comprehend
behind
interactions
underscoring
crucial
balanced
microbiome
optimal
health
positioning
saponins
dietary
interventions
managing
conditions.
