Al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences,
Journal Year:
2023,
Volume and Issue:
37(Supplement I-IV), P. 121 - 128
Published: Dec. 1, 2023
Cutaneous
wounds
are
significant
problems
that
can
be
treated
with
traditional
herbal
supplements.
This
study
evaluated
the
wound
healing
potential
of
Quercus
aegilops
barks
extract
formulations
on
excision
wounds.
BQAE
extractions
were
acquired
and
employed
to
make
two
distinct
formulas,
namely,
10
20%
extract.
These
applied
topically
once
daily
for
12
days
check
out
their
capacity
heal
in
a
mice
model
repair.
At
0,3,6,9
days,
sizes
areas
observed.
Hematoxylin
Eosin
staining
used
skin
tissue
samples
histopathological
evaluation.
The
ointments
found
stable
skin-safe.
Comparing
contraction
area
positive
(standard
reference
Povidone-iodine)
negative
controls,
both
caused
substantial
(P<0.05)
reduction
these
parameters
(wound
area).
A
increase
levels
Reduced
glutathione,
Superoxide
dismutase,
Catalase,
as
decrease
Malondialdehyde
was
observed
groups
when
compared
groups.
studies
biopsy
day
increased
collagen
formation,
number
neovascularization,
reformation
sebaceous
glands,
full
thickness
epithelization
epidermal
layer
soon
standard
Povidone-
iodine
10%
(positive
control)
control
Thus,
vitro
(physical
properties
ointment)
vivo
scientifically
validated
wound-healing
activity
(BQAE),
which
explained
production
antioxidant
activity,
thereby
supporting
claims.
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 193 - 213
Published: Jan. 31, 2024
Ulcer
disorders
including
the
oral
mucosa,
large
intestine,
and
stomach
cause
significant
global
health
burdens.
Conventional
treatments
such
as
non-steroid
anti-inflammatory
drugs
(NSAIDs),
proton
pump
inhibitors
(PPIs),
histamine
H
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 403 - 403
Published: March 13, 2025
Background:
Carotenoids
are
bioactive
tetraterpenoid
C40
pigments
that
actively
synthesized
by
plants,
bacteria,
and
fungi.
Compounds
such
as
α-carotene,
β-carotene,
lycopene,
lutein,
astaxanthin,
β-cryptoxanthin,
fucoxanthin,
zeaxanthin
have
attracted
increasing
attention
for
their
antiaging
properties.
They
exhibit
antioxidant,
neuroprotective,
anti-inflammatory
properties,
contributing
to
the
prevention
treatment
of
age-related
diseases.
Objectives:
The
aim
this
study
was
comprehensively
analyze
pharmacological
potential
biological
mechanisms
carotenoids
associated
with
disorders
evaluate
application
in
nutraceuticals,
pharmaceuticals,
cosmeceuticals.
Methods:
A
systematic
review
studies
published
over
past
two
decades
conducted
using
databases
PubMed,
Scopus,
Web
Science.
selection
criteria
included
clinical,
silico,
vivo,
vitro
investigating
therapeutic
effects
carotenoids.
Results:
demonstrate
a
variety
health
benefits,
including
macular
degeneration,
cancer,
cognitive
decline,
metabolic
disorders,
skin
aging.
Their
role
nutraceuticals
is
well
supported
ability
modulate
oxidative
stress
inflammatory
pathways.
In
show
promising
results
formulations
targeting
neurodegenerative
diseases
disorders.
cosmeceuticals,
they
improve
protecting
it
against
UV
radiation
damage.
However,
bioavailability,
optimal
dosages,
toxicity,
interactions
other
compounds
remain
critical
factors
maximize
efficacy
still
require
careful
evaluation
scientists.
Conclusions:
interventions
applications
fields.
Further
research
needed
optimize
formulas,
confirm
long-term
safety
effectiveness,
especially
aging
population.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(5), P. e27598 - e27598
Published: March 1, 2024
Diabetes
is
a
significant
global
health
concern
that
increases
the
vulnerability
to
various
chronic
illnesses.
In
view
of
this
issue,
current
research
aimed
examine
effects
administering
an
extract
derived
from
tubers
Cyperus
rotundus
L
(CrE)
on
obesity,
type
1
diabetes,
and
liver-kidney
toxicity.
Through
utilization
HPLC-DAD
analysis,
it
was
discovered
contained
several
components,
including
quercetin
(47.8%),
luteolin
glucoside
(17%),
(7.56%),
apigenin-7-glucoside
(6.29%),
naringinin
(4.52%),
seven
others.
vitro
experiments
they
have
demonstrated
CrE
effectively
inhibited
key
digestive
enzymes
associated
with
obesity
2
such
as
DPP-4,
PTP1B,
lipase,
α-amylase,
evidenced
by
their
respective
IC50
values
are
about
23,
51,83,
67
μg/ml
respectively.
Furthermore,
when
diabetic
rats
were
administered
CrE,
activity
pancreatic
linked
inflammation,
namely
5-lipoxygenase
(5-LO),
hyaluronidase
(HAase),
myeloperoxidase
(MPO),
significantly
suppressed
48,
41,
75,
47%,
Moreover,
exhibited
protective
β-cells
inhibiting
formation
thiobarbituric
acid
reactive
substances
(TBARS)
65%
induction
superoxide
Dismutase
(SOD),
catalase
(CAT)
glutathione
peroxidase
(GPX)
activities
62,
108,
112%
respectively
compared
untreated
rat.
Additionally,
intestinal,
pancreatic,
serum
lipase
α-amylase
activities.
rats,
administration
glycogen
phosphorylase
(GP)
stimulated
synthase
(GS)
45
30%;
increased
liver
content
45%.
modulated
hepatic
involved
in
carbohydrate
metabolism,
hexokinase
(HK),
glucose-6-phosphate
dehydrogenase
(G6PD),
glucose-6-phosphatase
(G6P),
fructose-1,6-bisphosphatase
(FBP).
Notably,
average
food
water
intake
(AFI
AWI)
treated
reduced
15
16%
those
without
any
treatment.
Therefore,
study
effectiveness
preventing
treating
diabetes.
Resources,
Journal Year:
2022,
Volume and Issue:
11(10), P. 91 - 91
Published: Oct. 3, 2022
The
municipal
authorities
in
developing
nations
face
serious
challenges
marigold
flower
garbage
management.
primary
issue
is
that
they
never
are
reused
after
prayers.
Flower
waste
of
Tagetes
erecta,
T.
patula,
and
Calendula
officinalis
L.
commonly
used
for
carotenoid
flavonoid
extractions
and,
subsequently,
incense
stick
biogas
production.
Marigold
plants
also
phytoremediation
during
their
growth
stage.
lutein
industry
booming
due
to
its
increasing
market
demand,
expected
reach
~2121.2
billion
tons
by
2022,
where
marigolds
a
major
contributor
globally.
process
isolating
from
saponified
oleoresin
yields
product
with
70–85%
purity.
Lutein
xanthophyll
(70–88%)
petals,
maximum
21.23
mg/g
was
extracted.
This
review
discusses
the
properties
selective
species,
compositions,
extraction
different
flavonoids
carotenoids,
especially
lutein.
Moreover,
methods
lutein,
collection
waste,
subsequent
utilization
derive
several
value-added
products
discussed.
Among
physical
treatments,
ultrasonic-assisted
enzymatic
treatment
5%
solids
loading
were
maximum-yielding
methods.
Journal of Functional Foods,
Journal Year:
2024,
Volume and Issue:
117, P. 106228 - 106228
Published: May 6, 2024
The
study
investigates
the
medicinal
properties
of
Tagetes
erecta
L.
(marigold)
in
combating
inflammation
and
toxicity
induced
by
lipopolysaccharides
(LPS).
polyphenol-enriched
extract
from
T.
petals
(TE)
exhibited
significant
anti-inflammatory
effects
targeting
Toll-like
receptor
4
(TLR4)/myeloid
differentiation
factor
2
(MD2)
complex,
as
evidenced
cellular
animal
models.
In
vitro,
TE
effectively
inhibited
LPS-induced
proinflammatory
mediators
key
genes
associated
with
inflammation.
Molecular
docking
analyses
suggested
that
constituents
TE,
such
patulitrin,
quercetagetin,
kaempferol,
patuletin,
isorhamnetin,
have
potential
to
bind
TLR4/MD2
therefore
supporting
its
effects.
Experiments
on
zebrafish
larvae
revealed
mitigates
abnormalities
mortality,
well
attenuates
expression
genes,
highlighting
therapeutic
potential.
Overall,
underscores
promising
value
L.,
particularly
addressing
disorders,
thus
warranting
further
exploration
clinical
applications.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
25(1), P. 280 - 280
Published: Dec. 24, 2023
Tagetes
erecta
is
an
edible
flower
deeply
rooted
in
traditional
Mexican
culture.
It
holds
a
central
role
the
most
popular
and
iconic
celebration,
“the
Day
of
Dead”.
Furthermore,
it
currently
receiving
interest
as
potential
therapeutic
agent,
motivated
mainly
by
its
polyphenol
content.
The
present
study
aims
to
evaluate
biological
activity
extract
synthesized
from
petals
T.
erecta.
This
showed
significant
antioxidant
scores
measured
common
vitro
methodologies
(FRAP,
ABTS,
DPPH),
with
values
1475.3
μM
trolox/g
extr,
1950.3
977.7
respectively.
In
addition,
up
36
individual
polyphenols
were
identified
chromatography.
Regarding
biomedical
aspects
petal
extract,
exhibited
antitumoral
against
ovarian
carcinoma
cells
evaluated
MTS
assay,
revealing
lower
value
IC50
compared
other
extracts.
For
example,
reported
half
low
Rosa
×
hybrida
six
times
than
another
Tulbaghia
violacea.
effect
arises
induction
apoptotic
process;
thus,
incubating
increased
rate
flow
cytometry.
Moreover,
also
demonstrated
efficacy
agent
tauopathy,
feature
Alzheimer’s
disease
(AD)
Caenorhabditis
elegans
experimental
model.
Treating
worms
prevented
disfunction
several
motility
parameters
such
wavelength
swimming
speed.
release
Reactive
Oxygen
Species
(ROS),
which
are
associated
progression
AD.
Thus,
treatment
resulted
approximate
20%
reduction
ROS
production.
These
findings
suggest
that
these
could
serve
suitable
source
for
applications.
Horticulturae,
Journal Year:
2024,
Volume and Issue:
10(8), P. 846 - 846
Published: Aug. 9, 2024
Using
desi-cow
waste
products
like
Jeevamrit
under
natural
farming
is
widespread
among
farmers
for
improving
soil
biology
and
productivity.
enhances
chemical
microbiological
properties
without
needing
a
large
quantity
of
farmyard
manure
(FYM)
as
sustainable
practice
with
reduced
carbon
footprint.
Despite
its
traditional
use,
faces
criticism
due
to
lack
scientific
evidence.
This
study
investigated
the
comparative
effect
fertilizers
on
growth
yield
marigold
cv.
Siracole.
The
experiment
employed
randomized
block
design
(RBD)
three
replications.
mother
marigolds
was
raised
both
summer
winter
seasons.
From
this
block,
harvesting
flushes
were
taken
propagated
from
cuttings.
rooted
cuttings
planted
at
monthly
intervals
evaluated
flowering
parameters
compared
those
treated
RDF
(30:20:20
N,
P,
K
g/m2).
Soil
supplied
showed
enhanced
bacteria
(26.33%),
fungi
(18.92%),
actinomycetes
(31.21%)
populations
recommended
dose
(RDF)
(i.e.,
N–P–K
@
30:20:20
g
m−2).
Jeevamrit-treated
plants
have
more
marketable
flower
per
square
meter
(3.98%)
longer
shelf
life
(9.93%)
RDF.
concludes
that
2
liters
m−2
effective
alternative
enhancing
production
in
mid-hills
Himachal
Pradesh,
where
already
accepted.
