From natural environment to animal tissues: A review of microplastics(nanoplastics) translocation and hazards studies

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 855, P. 158686 - 158686

Published: Sept. 10, 2022

Language: Английский

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Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway

Environmental Pollution, Journal Year: 2022, Volume and Issue: 300, P. 118986 - 118986

Published: Feb. 12, 2022

Language: Английский

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The potential impacts of micro-and-nano plastics on various organ systems in humans

EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104901 - 104901

Published: Dec. 6, 2023

Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems not yet fully understood. This review aims provide an overview potential impacts and identify knowledge gaps in current research. The summarized results suggest that exposure can lead oxidative stress, inflammation, immune dysfunction, altered biochemical energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal development, carcinogenicity. There is limited human data MNPs, despite evidence from animal cellular studies. Most published research has focused specific types assess their toxicity, while other plastic particles commonly found environment remain unstudied. Future studies should investigate by considering realistic concentrations, dose-dependent effects, individual susceptibility, confounding factors.

Language: Английский

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Harmful effects of the microplastic pollution on animal health: a literature review

PeerJ, Journal Year: 2022, Volume and Issue: 10, P. e13503 - e13503

Published: June 14, 2022

The environmental pollution by microplastics is a global problem arising from the extensive production and use of plastics. Small particles different plastics, measured less than 5 mm in diameter, are found water, air, soil, various living organisms around globe. Humans constantly inhale ingest these particles. associated health risks raise major concerns require dedicated evaluation.In this review we systematize summarize effects on animals. article would be interest to ecologists, experimental biologists, physicians, all those concerned with anthropogenic changes.We searched PubMed Scopus period 01/2010 09/2021 for peer-reviewed scientific publications focused (1) microplastics; (2) uptake humans; (3) impact animal health.The number published studies considering microplastic aquatic considerable. In invertebrates, cause decline feeding behavior fertility, slow down larval growth development, increase oxygen consumption, stimulate reactive species. fish, may structural damage intestine, liver, gills, brain, while affecting metabolic balance, behavior, fertility; degree harmful depends particle sizes doses, as well exposure parameters. corresponding data terrestrial mammals abundant: only 30 papers deal laboratory mice rats; remarkably, about half were 2021, indicating growing community issue. demonstrate that rats also biochemical noticeable dysfunctions excretory reproductive systems.Microplastics pollute seas negatively affect organisms. obtained suggest profound negative influence human health. However, given significant variation plastic types, sizes, models, modes administration, available still fragmentary controversial.

Language: Английский

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Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice

Chemosphere, Journal Year: 2021, Volume and Issue: 288, P. 132607 - 132607

Published: Oct. 20, 2021

Language: Английский

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Toxic Chemicals and Persistent Organic Pollutants Associated with Micro-and Nanoplastics Pollution

Chemical Engineering Journal Advances, Journal Year: 2022, Volume and Issue: 11, P. 100310 - 100310

Published: April 29, 2022

The prevalence of micro and nanoplastics (MNPs) across the various environments their negative impact on ecosystems have become a serious global threat are currently subject many environmental concerns. Studies provided evidence that MNPs potential to leach toxic plastic chemical additives can adsorb variety persistent organic pollutants, thereby enhancing bioavailability, toxicity, dispersion. Moreover, these easily penetrate food chain might cause health problems when ingested by humans other organisms. Currently, there is complexity in understanding mechanisms which chemicals adsorb/desorb onto/from MNPs, physical biological impacts additives. To date, considerable lack knowledge major concern used industry, fate once dispose into environment, factors affect degradation, consequent human health. This review critically analyzes current concerning physical, chemical, pollutants associated with MNPs. Emphasis was laid types, occurrence, fate, distribution environment. different techniques identification, characterization, removal were also elucidated. Furthermore, harmful effects discussed spur more future studies fill gaps this area.

Language: Английский

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Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2

Environmental Pollution, Journal Year: 2021, Volume and Issue: 289, P. 117904 - 117904

Published: Aug. 3, 2021

Language: Английский

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Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 838, P. 155825 - 155825

Published: May 19, 2022

Language: Английский

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Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway

Chemosphere, Journal Year: 2022, Volume and Issue: 307, P. 135662 - 135662

Published: July 10, 2022

Language: Английский

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Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts

iScience, Journal Year: 2023, Volume and Issue: 26(2), P. 106061 - 106061

Published: Jan. 28, 2023

Microplastics and nanoplastics (M-NPLs) are ubiquitous environmentally, chemically, or mechanically degraded plastic particles. Humans exposed to M-NPLs of various sizes types through inhalation contaminated air, ingestion water food, other routes. It is estimated that Americans ingest tens thousands millions particles yearly, depending on socioeconomic status, age, gender. have spurred interest in toxicology because their abundance, nature, ability penetrate bodily cellular barriers, producing toxicological effects cells, tissues, organs, organ systems. The present review paper highlights: (1) current knowledge understanding the detrimental mouse models human cell lines, (2) organelle localization M-NPLs, underlying uptake mechanisms focusing endocytosis, (3) possible pathways involved toxicity, particularly reactive oxygen species, nuclear factor-erythroid factor 2-related 2 (NRF2), Wnt/β-Catenin, Nuclear Factor Kappa B (NF-kB)-regulated inflammation, apoptosis, autophagy signaling. We also highlight potential role increasing incubation time, spread, transport COVID-19 virus. Finally, we discuss future prospects this field.

Language: Английский

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