Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Language: Английский

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Recent advances in the development and analytical applications of oxidase-like nanozymes

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 166, P. 117220 - 117220

Published: Aug. 3, 2023

Language: Английский

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Research Progress in Iron-Based Nanozymes: Catalytic Mechanisms, Classification, and Biomedical Applications

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(29), P. 10844 - 10858

Published: July 12, 2023

Natural enzymes are crucial in biological systems and widely used biology medicine, but their disadvantages, such as insufficient stability high-cost, have limited wide application. Since Fe3O4 nanoparticles were found to show peroxidase-like activity, researchers designed developed a growing number of nanozymes that mimic the activity natural enzymes. Nanozymes can compensate for defects higher with lower cost. Iron, nontoxic low-cost transition metal, has been synthesize variety iron-based unique structural physicochemical properties obtain different mimicking catalytic properties. In this perspective, mechanisms, modulation, recent research progress sensing, tumor therapy, antibacterial anti-inflammatory applications systematically presented. The challenges perspectives on development also analyzed discussed.

Language: Английский

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Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Language: Английский

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Research progress of nanozymes in colorimetric biosensing: Classification, activity and application

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150612 - 150612

Published: March 21, 2024

Language: Английский

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Nanozymes: powerful catalytic materials for environmental pollutant detection and degradation

Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(3), P. 766 - 796

Published: Jan. 1, 2024

Here we made a critical review on nanozyme-involved detection and degradation of environmental pollutants, the research progress achieved in last five years was emphatically concluded.

Language: Английский

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Bismuth-based metal-organic framework peroxidase-mimic nanozyme: Preparation and mechanism for colorimetric-converted ultra-trace electrochemical sensing of chromium ion

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 451, P. 131148 - 131148

Published: March 5, 2023

Language: Английский

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Biomimetic cascade intelligent paper chip sensor based on bimetallic porphyrin-based covalent organic framework with triple-enzyme mimetic activities

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151628 - 151628

Published: April 25, 2024

Language: Английский

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Dual pathway reduction of Mo4+ and photogenerated electrons restore catalytic sites to enhance heterogeneous peroxymonosulfate activation system

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 452, P. 139246 - 139246

Published: Sept. 16, 2022

Language: Английский

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Nanozymes with Multiple Activities: Prospects in Analytical Sensing

Biosensors, Journal Year: 2022, Volume and Issue: 12(4), P. 251 - 251

Published: April 16, 2022

Given the superiorities in catalytic stability, production cost and performance tunability over natural bio-enzymes, artificial nanomaterials featuring enzyme-like characteristics (nanozymes) have drawn extensive attention from academic community past decade. With these merits, they are intensively tested for sensing, biomedicine environmental engineering. Especially analytical sensing field, enzyme mimics found wide use biochemical detection, monitoring food analysis. More fascinatingly, rational design enables one fabrication of materials with versatile activities, which show great promise further advancement nanozyme-involved field. To understand progress such an exciting here we offer a review nanozymes multiple activities their application prospects. The main types enzyme-mimetic first introduced, followed by summary current strategies that can be employed to multi-activity nanozymes. In particular, typical at least two reviewed. Finally, opportunities applied field discussed, potential challenges also presented, better guide development methods sensors using different features.

Language: Английский

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