Hygiene and Sanitation,
Journal Year:
2023,
Volume and Issue:
102(12), P. 1334 - 1347
Published: Dec. 28, 2023
Environmental
contamination
by
polymer
wastes
and
microplastics
(MPs)
has
recently
become
important
for
health
care,
due
to
the
emergence
of
a
lot
evidence
that
MPs
affect
living
organisms,
including
humans.
commonly
presented
in
drinking
water
various
groups
food
products,
are
found
human
stool,
colon
tissue,
blood
samples.
When
orally
ingested,
first
object
their
interaction
with
organism
is
gastrointestinal
microbiota.
Considering
essential
importance
intestinal
microbiota
health,
study
negative
consequences
such
contact
becomes
very
important.
The
results
“in
vitro”
vivo”
experimental
studies
summarized
review
indicate
have
effects
on
microbial
community
composition
barrier
state,
themselves
subject
degradation
tract.
“In
studies,
entry
into
intestine
accompanied
an
increase
α-diversity
microbiota,
presumably
foreign
microorganisms
attached
particles,
those
as
part
biofilms
formed
surfaces.
Competing
representatives
normal
flora,
these
able
enzymatically
degrade
or
overcome
mucosal
barrier.
Simultaneously
biofilm
matrix
associate
mucus
provides
particles
retention
mucin
layer
direct
apical
epitheliocytes.
This
leads
irritation,
local
inflammation,
damage
biotransformation
products
can
also
systemically
host
organism,
translocating
from
bloodstream.
emphasizes
identify
characterize
risks
associated
intake
food,
assessing
pathways
necessary.
Environmental Science and Ecotechnology,
Journal Year:
2024,
Volume and Issue:
21, P. 100428 - 100428
Published: May 3, 2024
Micro/nanoplastics
(MNPs)
are
detected
in
human
liver,
and
pose
significant
risks
to
health.
Oral
exposure
MNPs
derived
from
non-biodegradable
plastics
can
induce
toxicity
mouse
liver.
Similarly,
nasal
cause
airway
dysbiosis
mice.
However,
the
hepatotoxicity
induced
by
foodborne
airborne
biodegradable
remains
poorly
understood.
Here
we
show
hepatotoxic
effects
of
polylactic
acid
(PLA)
through
multi-omics
analysis
various
biological
samples
mice,
including
gut,
fecal,
nasal,
lung,
blood
samples.
Our
results
that
both
PLA
compromise
liver
function,
disrupt
serum
antioxidant
activity,
pathology.
Specifically,
lead
gut
microbial
dysbiosis,
metabolic
alterations
serum,
transcriptomic
changes.
Airborne
affect
lung
microbiota,
alter
metabolites,
transcriptomics.
The
Lachnospiraceae_NK4A136_group
is
a
potential
biomarker
for
MNP
exposure,
while
unclassified
AJP Endocrinology and Metabolism,
Journal Year:
2023,
Volume and Issue:
324(6), P. E488 - E505
Published: May 3, 2023
Plastic
pollution
breaks
a
planetary
boundary
threatening
wildlife
and
humans
through
its
physical
chemical
effects.
Of
the
latter,
release
of
endocrine
disrupting
chemicals
(EDCs)
has
consequences
on
prevalence
human
diseases
related
to
system.
Bisphenols
(BPs)
phthalates
are
two
groups
EDCs
commonly
found
in
plastics
that
migrate
into
environment
make
low-dose
exposure
ubiquitous.
Here
we
review
epidemiological,
animal,
cellular
studies
linking
BPs
altered
glucose
regulation,
with
emphasis
role
pancreatic
β-cells.
Epidemiological
indicate
is
associated
diabetes
mellitus.
Studies
animal
models
treatment
doses
within
range
decreases
insulin
sensitivity
tolerance,
induces
dyslipidemia,
modifies
functional
β-cell
mass
serum
levels
insulin,
leptin,
adiponectin.
These
reveal
disruption
physiology
by
plays
key
impairing
homeostasis
altering
mechanisms
used
β-cells
adapt
metabolic
stress
such
as
chronic
nutrient
excess.
at
level
demonstrate
modify
same
biochemical
pathways
involved
adaptation
excess
fuel.
include
changes
biosynthesis
secretion,
electrical
activity,
expression
genes,
mitochondrial
function.
The
data
summarized
here
important
risk
factors
for
mellitus
support
global
effort
decrease
plastic
EDCs.
Environment International,
Journal Year:
2023,
Volume and Issue:
183, P. 108350 - 108350
Published: Nov. 25, 2023
Micro/nanoplastics
(MNP)
are
ubiquitous
in
the
environment
and
multiple
living
organisms.
The
toxicity
of
some
common
types
MNP,
e.g.,
polyethersulfone
(PES)
remains
poorly
understood.
Multi-omics
approaches
were
used
this
study
to
determine
effects
foodborne
airborne
PES
MNP
on
liver
lung,
respectively.
Foodborne
capable
inducing
gut
microbial
dysbiosis,
serum
metabolic
disruption,
transcriptomic
dysregulation,
affecting
antioxidant
activity
function,
resulting
injury.
As
for
they
found
induce
nasal
lung
transcriptome
disturbance,
cause
disrupted
NP
respectively
greater
than
MP,
which
could
be
associated
with
differences
between
MP
exposures.
relevant
results
suggest
that
disrupt
"gut
microbiota-gut-liver"
axis
hepatic
injury,
while
affect
"airborne
microbiota-lung"
findings
benefit
diagnoses
injury
induced
by
as
well
proper
use
human
environment.
