Long-COVID Symptoms in Individuals Infected with Different SARS-CoV-2 Variants of Concern: A Systematic Review of the Literature

Viruses, Journal Year: 2022, Volume and Issue: 14(12), P. 2629 - 2629

Published: Nov. 25, 2022

The association of SARS-CoV-2 variants with long-COVID symptoms is still scarce, but new data are appearing at a fast pace. This systematic review compares the prevalence according to relevant in COVID-19 survivors. MEDLINE, CINAHL, PubMed, EMBASE and Web Science databases, as well medRxiv bioRxiv preprint servers, were searched up 25 October 2022. Case-control cohort studies analyzing presence post-COVID after an acute infection by Alpha (B.1.1.7), Delta (B.1.617.2) or Omicron (B.1.1.529/BA.1) included. Methodological quality was assessed using Newcastle-Ottawa Scale. From 430 identified, 5 peer-reviewed 1 met inclusion criteria. sample included 355 patients infected historical variant, 512 41,563 57,616 variant. methodological all high. higher individuals variant (50%) compared those Alpha, variants. It seems that smallest, current heterogeneous, long-term have, this stage, obviously shorter follow-up earlier Fatigue most prevalent symptom variants, pain likewise prevalent. available suggest results fewer previous variants; however, small number lack control cofounders, e.g., reinfections vaccine status, some limit generality results. appears more likely develop symptomatology.

Language: Английский

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Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant

Pathogens, Journal Year: 2022, Volume and Issue: 11(7), P. 725 - 725

Published: June 25, 2022

This study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated because in one hospital during three different waves pandemic (Wuhan, Delta) were scheduled for a telephone interview. The presence was systematically assessed. Hospitalization clinical data collected from medical records. A total 201 patients infected Wuhan variant, 211 variant 202 assessed six months after hospitalization. Patients had greater number admission (higher prevalence fever, dyspnea gastrointestinal problems) than those (p < 0.01). proportion reported headache, anosmia ageusia as onset mean higher 0.001) (mean: 2.7 ± 1.3) 1.8 1.1) 2.1 1.5) Post-COVID-19 more prevalent people whereas hair loss = 0.002). No differences fatigue by found 0.594). Differences COVID-19 associated observed depending on common symptom to all variants.

Language: Английский

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Variability in the Clinical Course of COVID-19 in a Retrospective Analysis of a Large Real-World Database

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 149 - 149

Published: Jan. 3, 2023

The COVID-19 pandemic proceeds in waves, with variable characteristics of the clinical picture resulting from evolution SARS-CoV-2 virus. This study aimed to compare epidemiological characteristics, symptomatology, and outcomes disease patients hospitalized for during periods different variants dominance. Comparing dominance preceding Delta variant, period was characterized by a higher share females, less frequent comorbidities among patients, age distribution. lowest need oxygen therapy mechanical ventilation observed under Omicron triad classic symptoms, cough, fever, dyspnoea, fatigue, were most prevalent period, significantly common During nearly twice as many previous could be discharged hospital within 7 days; overall 28-day mortality lower compared that period. It also did not differ between dominated BA.1 BA.2 subvariants. indicates variant January June 2022 caused which resembled cold, seasonal alpha beta-coronaviruses low pathogenicity humans. However, one should note this effect may only have been related biological features lineage, but additionally driven increased levels immunization through natural infections vaccinations, we account due lack sufficient data.

Language: Английский

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Comparison of Symptoms Associated With SARS-CoV-2 Variants Among Children in Canada

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(3), P. e232328 - e232328

Published: March 9, 2023

Importance Clinical manifestations of SARS-CoV-2 variants have not been systematically compared in children. Objective To compare symptoms, emergency department (ED) chest radiography, treatments, and outcomes among children with different variants. Design, Setting, Participants This multicenter cohort study was performed at 14 Canadian pediatric EDs. included adolescents younger than 18 years (hereinafter referred to as children) tested for infection an ED between August 4, 2020, February 22, 2022, days follow-up. Exposure(s) detected on a specimen collected from the nasopharynx, nares, or throat. Main Outcomes Measures The primary outcome presence number presenting symptoms. secondary were core COVID-19 radiography findings, 14-day outcomes. Results Among 7272 participants ED, 1440 (19.8%) had test results positive infection. Of these, 801 (55.6%) boys, median age 2.0 (IQR, 0.6-7.0) years. Children Alpha variant reported fewest symptoms (195 237 [82.3%]), which most often by Omicron (434 468 [92.7%]; difference, 10.5% [95% CI, 5.1%-15.9%]). In multivariable model original type referent, Delta associated fever (odds ratios [ORs], 2.00 1.43-2.80] 1.93 1.33-2.78], respectively) cough (ORs, 1.42 1.06-1.91] 1.57 1.13-2.17], respectively). Upper respiratory tract (OR, 1.96 1.38-2.79]); lower systemic 1.04-1.92] 1.77 1.24-2.52], received treatments; those who infection, they more likely (difference, 9.7% 4.7%-14.8%]), receive intravenous fluids 5.6% 1.0%-10.2%]) corticosteroids 7.9% 3.2%-12.7%]), revisit 8.8% 3.5%-14.1%]). proportions admitted hospital intensive care unit did differ Conclusions Relevance findings this suggest that strongly original-type virus variant. report manifestations, undergo interventions. No differences found undesirable (ie, hospitalization, admission) across

Language: Английский

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Clinical characteristics of the Omicron variant - results from a Nationwide Symptoms Survey in the Faroe Islands

International Journal of Infectious Diseases, Journal Year: 2022, Volume and Issue: 122, P. 636 - 643

Published: July 8, 2022

Omicron appears to lead a milder illness for patients compared with previous COVID-19 variants. However, not all infected would describe their as mild. In this study, we investigate the experienced severity and symptoms of variant.We conducted nationwide cross-sectional including 5036 individuals ages, consisting reverse transcription-polymerase chain reaction confirmed SARS-CoV-2 cases from 1 January 31 2022 (n = 4506) control group without SARS-COV-2 infection in December 2021 or 530). was dominant during period. Cases were asked about acute answered web-based questionnaire 10-30 days after positive test while controls past week.Among cases, 97% reported at least one symptom phase 79% controls. Just over half assessed asymptomatic mild, whereas 46% moderate severe. Children fewer less severe illnesses than adults (P <0.001). The largest risk differences (RDs) between adult due observed fever (RD 60.6%, confidence interval [CI] 57.4-63.6), fatigue 49.6%, CI 44.1-54.7), chills 48.8%, 43.8-53.2).Most those experience symptoms, variant disease. does mean that an unprecedented rate infections worldwide leads urgent questions long COVID infections.

Language: Английский

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SARS-CoV-2 Omicron infection is associated with high nasopharyngeal viral load

Journal of Infection, Journal Year: 2022, Volume and Issue: 84(6), P. 834 - 872

Published: Feb. 26, 2022

Language: Английский

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SARS-CoV-2 B.1.1.529 (Omicron) Variant Causes an Unprecedented Surge in Children Hospitalizations and Distinct Clinical Presentation Compared to the SARS-CoV-2 B.1.617.2 (Delta) Variant

Frontiers in Pediatrics, Journal Year: 2022, Volume and Issue: 10

Published: June 27, 2022

Background In the midst of successive waves SARS-CoV-2 variants, B.1.1.529 (omicron) variant has recently caused a surge in pediatric infections and hospitalizations. This study aimed to describe compare symptoms, explorations, treatment evolution COVID-19 hospitalized children during B.1.617.2 (delta) waves. Methods observational was performed Pediatric Pulmonology Department University Hospital Paris, France. All aged between 0 18 years who tested positive for using reverse transcription polymerase chain reaction (RT-PCR) nasopharyngeal swabs from July 15th December 2021 (delta wave), February 28th 2022 (omicron wave) were included. Results total, 53 included, 14 (26.4%) delta wave 39 (73.6%) omicron (almost three times as many hospitalizations half time latter wave). During wave, patients mostly &lt; 5 (90 vs. 71% all waves, respectively), tended have fewer underlying conditions (56 79% respectively, p = 0.20). The also responsible different clinical presentation when compared variant, with significantly higher often poorly tolerated temperatures ( 0.03) increased digestive symptoms 0.01). None older than 12 fully vaccinated. Conclusion dramatic increase hospitalization modification latest require pediatricians remain vigilant. It should encourage caregivers ensure vaccination years, whom BNT162b2 vaccine been deemed safe, immunogenic, effective.

Language: Английский

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Changes in symptoms and characteristics of COVID-19 patients across different variants: two years study using neural network analysis

BMC Infectious Diseases, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 28, 2023

Considering the fact that COVID-19 has undergone various changes over time, its symptoms have also varied. The aim of this study is to describe and compare in personal characteristics, symptoms, underlying conditions individuals infected with different strains COVID-19.This descriptive-analytical was conducted on 46,747 patients who underwent PCR testing during a two-year period from February 22, 2020 23, 2022, South Khorasan province, Iran. Patient characteristics were extracted based self-report information system. data analyzed using logistic regression artificial neural network approaches. R software used for analysis significance level 0.05 considered tests.Among cases analyzed, 23,239 (49.7%) male, mean age 51.48 ± 21.41 years. There significant difference among variants disease (p < 0.001). factors positive association myalgia (OR: 2.04; 95% CI, 1.76 - 2.36), cough 1.93; 1.68-2.22), taste or smell disorder 2.62; 2.1 3.28). Additionally, aging found increase likelihood across six periods.We older age, myalgia, taste/smell are better compared dyspnea high body temperature, identifying patient. As evolved, chills diarrhea, demonstrated prognostic strength as Omicron.

Language: Английский

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Adjusted control rate closely associated with the epidemiologic evolution of the recent COVID-19 wave in Shanghai, with 94.3% of all new cases being asymptomatic on first diagnosis

Journal of Infection, Journal Year: 2022, Volume and Issue: 85(4), P. e89 - e91

Published: July 16, 2022

Language: Английский

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Addressing Google Trends inconsistencies

Technological Forecasting and Social Change, Journal Year: 2024, Volume and Issue: 202, P. 123318 - 123318

Published: March 4, 2024

Google Trends reports the evolution of popularity internet searches. Its main output is Search Volume Index (SVI), a relative measure term computed using sample Due to sampling, SVI series are not entirely consistent, as same query produces different results that can widely change from day day. This paper investigates nature these inconsistencies by modeling and simulating data-generating process. Simulations applied describe how typical time distorted due sampling process quantify averaging extractions smoothes series. Finally, relationship between popularity, dispersion, averaged derived, so recommendations for constructing consistent SVIs be provided.

Language: Английский

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