Journal of Molecular Structure, Journal Year: 2021, Volume and Issue: 1230, P. 129928 - 129928
Published: Jan. 12, 2021
Language: Английский
Biosensors, Journal Year: 2021, Volume and Issue: 11(4), P. 97 - 97
Published: March 26, 2021
Retinoblastoma is a rare type of cancer, and its treatment, as well diagnosis, challenging, owing to mutations in the tumor-suppressor genes lack targeted, efficient, cost-effective therapy, exhibiting significant need for novel approaches address these concerns. For this purpose, nanotechnology has revolutionized field medicine with versatile potential capabilities both retinoblastoma via targeted controlled delivery anticancer drugs binding overexpressed gene. Nanotechnology also generated massive advancements treatment based on use surface-tailored multi-functionalized nanocarriers; receptor-based nanocarriers ligands (folate, galactose, hyaluronic acid); lipid-based metallic nanocarriers. These seem benchmark mitigating plethora malignant at specified site, resulting programmed apoptosis cancer cells. The effectiveness nanoplatforms diagnosing treating intraocular cancers such not been properly discussed, despite increasing significance nanomedicine management. This article reviewed recent milestones future development areas drug diagnostic platforms focused nanotechnology.
Language: Английский
Citations
64
International Materials Reviews, Journal Year: 2022, Volume and Issue: 68(1), P. 1 - 25
Published: Jan. 26, 2022
In the last two decades nanogels have emerged as very promising and versatile biomaterials suitable for a wide range of applications. Their features such large surface area, ability to hold molecules, flexibility in size water-based formulations ensured them great recognition drug delivery systems with various vivo applications which confirmed their potential. On other handnanogels been investigated recent years fields than biomedicine. Clear examples this are represented by possibility employing sensing materials, catalysts or adsorbents environmental view variety possible applications, work we extend our knowledge on topic uses described literature, taking stock state art all nanogel employment synthesis methods.
Language: Английский
Citations
43
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 1195 - 1218
Published: March 1, 2023
Abstract: Malignant tumor, the leading cause of death worldwide, poses a serious threat to human health. For decades, natural product has been proven be an essential source for novel anticancer drug discovery. Shikonin (SHK), molecule separated from root Lithospermum erythrorhizon , shows great potential in therapy. However, its further clinical application is significantly restricted by poor bioavailability, adverse effects, and non-selective toxicity. With development nanotechnology, nano delivery systems have emerged as promising strategies improve bioavailability enhance therapeutic efficacy drugs. To overcome shortcoming SHK, various such liposomes, polymeric micelles, nanoparticles, nanogels, nanoemulsions, were developed achieve efficient enhanced antitumor effects. Herein, this review summarizes pharmacological activities pharmacokinetics SHK. Additionally, latest progress SHK nanomedicines cancer therapy outlined, focusing on long circulation, tumor targeting ability, microenvironment responsive release, nanosystem-mediated combination Finally, challenges prospects future are spotlighted. Graphical Keywords: shikonin, therapy, pharmacokinetics, nanomedicine,
Language: Английский
Citations
37
Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 586 - 586
Published: Feb. 27, 2023
Citrus (genus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic divided into subclasses, in which flavanones the most prominent. Among them, naringenin and hesperidin emerging anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including modulation epigenetics, estrogen signaling, induction cell death via regulation apoptotic signaling pathways, inhibition tumor invasion metastasis. However, this information is sparse literature needs to be brought together provide an overview how can serve therapeutic tools drug development a successful co-adjuvant strategy against BC. This review detailed context highlighted could interfere BC carcinogenesis helpful potential alternative treatment.
Language: Английский
Citations
35
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1158 - 1158
Published: April 6, 2023
Nucleic acid (NA)-based biopharmaceuticals have emerged as promising therapeutic modalities. NA therapeutics are a diverse class of RNA and DNA include antisense oligonucleotides, siRNA, miRNA, mRNA, small activating RNA, gene therapies. Meanwhile, posed significant stability delivery challenges expensive. This article discusses the opportunities for achieving stable formulations NAs with novel drug systems (DDSs). Here we review current progress in issues significance DDSs associated NA-based biopharmaceuticals, well mRNA vaccines. We also highlight European Medicines Agency (EMA) US Food Drug Administration (FDA)-approved their formulation profiles. could impact future markets if remaining requirements addressed. Regardless limited information available therapeutics, reviewing collating relevant facts figures generates precious resource experts familiar therapeutics' profile, challenges, regulatory acceptance.
Language: Английский
Citations
32
Small, Journal Year: 2023, Volume and Issue: 19(50)
Published: Aug. 27, 2023
Abstract Dendrimers are a family of polymers with highly branched structure, well‐defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers ideal nanocarriers for delivering anticancer agents due to the explicit study their characteristics particle size, charge, biological properties such as toxicity, blood circulation time, biodistribution, cellular internalization. Here, classification, preparation, structure dendrimer micelles reviewed, specific groups modified on surface tumor active targeting, stimuli‐responsive drug release, reduced prolonged time discussed. In addition, applications summarized various platforms related cancer therapy including delivery, gene transfection, nano‐contrast imaging, combined therapy. Other tissue engineering biosensor also involved. Finally, possible challenges perspectives further
Language: Английский
Citations
32
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(26)
Published: Aug. 4, 2023
Abstract The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, have found significant role improving drug delivery inhibiting the growth metastasis tumor cells. Moreover, recent studies highlighted potential modulating microenvironment (TME) enhancing activity immune cells improve therapy efficacy. Various types are currently utilized carriers, immunosuppressants, activators, immunoassay reagents, more for immunotherapy. Necessarily, used immunotherapy can be grouped into two categories: organic inorganic nanomaterials. Though both shown ability achieve purpose immunotherapy, composition properties result differences mechanisms modes action. Organic further divided polymers, cell membranes, nanoemulsion‐modified, hydrogel forms. At same time, broadly classified nonmetallic metallic current work aims explore action these different prospects promoting
Language: Английский
Citations
31
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)
Published: Jan. 11, 2024
Abstract Brain cancers, especially glioblastoma multiforme, are associated with poor prognosis due to the limited efficacy of current therapies. Nanomedicine has emerged as a versatile technology treat various diseases, including and played an indispensable role in combatting COVID‐19 pandemic evidenced by that lipid nanocarrier‐based vaccines have played. The tunability nanocarrier physicochemical properties —including size, shape, surface chemistry, drug release kinetics— resulted development wide range nanocarriers for brain cancer treatment. These can improve pharmacokinetics drugs, increase blood‐brain barrier transfer efficiency, specifically target cells. unique features would potentially allow more efficient treatment fewer side effects better therapeutic outcomes. This review provides overview options, challenges latest advances nanomedicine strategies investigated emphasis on targeted stimulus‐responsive their potential clinical translation.
Language: Английский
Citations
15
BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4219 - 4237
Published: Jan. 10, 2024
Language: Английский
Citations
11
Cancer Chemotherapy and Pharmacology, Journal Year: 2025, Volume and Issue: 95(1)
Published: Jan. 4, 2025
Language: Английский
Citations
1