ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(36), P. 47124 - 47136
Published: Aug. 28, 2024
Nanocrystals
(NCs)
have
entirely
changed
the
panorama
of
hydrophobic
drug
delivery,
showing
improved
biopharmaceutical
performance
through
multiple
administration
routes.
NCs
are
potential
highly
loaded
nanovectors
due
to
their
pure
composition,
standing
out
from
conventional
polymers
and
lipid
nanoparticles
that
limited
drug-loading
capacity.
However,
research
in
this
area
is
limited.
This
study
introduces
concept
surface
modification
single-layer
poly(ethylene
glycol)
(PEG)
polymerization
as
an
innovative
strategy
boost
targeting
efficiency.
The
postpolymerization
analysis
revealed
size
composition
alterations,
indicating
successful
engineering
model
curcumin
approximately
200
nm.
Interestingly,
mucosal
tissue
penetration
showed
enhanced
entry
for
fully
coated
low
cross-linked
(LCS)
PEG
NCs,
with
increase
15
μg/cm2
compared
control
NCs.
In
addition,
we
found
polymer
chemistry
variations
on
NCs'
notably
impacted
mucin
binding,
those
armored
LCS
most
significant
reduction
interaction
glycoprotein.
We
validated
vitro
nose-to-brain
model,
all
exhibiting
a
promising
ability
cross
tight
monolayer.
Furthermore,
metabolic
pro-inflammatory
activity
clear
indications
that,
despite
modifications,
efficacy
remains
unaffected.
These
findings
highlight
PEGylated
targeted
delivery.
Altogether,
work
sets
baseline
further
exploration
optimization
polymerized
delivery
applications,
more
efficient
treatments
specific
disorders
conditions
requiring
active
targeting.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 3, 2023
Modern
agriculture
is
primarily
focused
on
the
massive
production
of
cereals
and
other
food-based
crops
in
a
sustainable
manner
order
to
fulfill
food
demands
an
ever-increasing
global
population.
However,
intensive
agricultural
practices,
rampant
use
agrochemicals,
environmental
factors
result
soil
fertility
degradation,
pollution,
disruption
biodiversity,
pest
resistance,
decline
crop
yields.
Thus,
experts
are
shifting
their
focus
eco-friendly
safer
methods
fertilization
ensure
sustainability.
Indeed,
importance
plant
growth-promoting
microorganisms,
also
determined
as
“plant
probiotics
(PPs),”
has
gained
widespread
recognition,
usage
biofertilizers
being
actively
promoted
means
mitigating
harmful
effects
agrochemicals.
As
bio-elicitors,
PPs
promote
growth
colonize
or
tissues
when
administered
soil,
seeds,
surface
used
alternative
avoid
heavy
In
past
few
years,
nanotechnology
brought
revolution
due
application
various
nanomaterials
(NMs)
nano-based
fertilizers
increase
productivity.
Given
beneficial
properties
NMs,
these
two
can
be
tandem
maximize
benefits.
combinations
NMs
PPs,
synergistic
use,
its
infancy
but
exhibited
better
crop-modulating
terms
improvement
productivity,
mitigation
stress
(drought,
salinity,
etc.),
restoration
fertility,
strengthening
bioeconomy.
addition,
proper
assessment
necessary
before
application,
dose
should
applicable
without
showing
any
toxic
impact
environment
microbial
communities.
The
combo
encapsulated
within
suitable
carrier,
this
method
aids
controlled
targeted
delivery
entrapped
components
increases
shelf
life
PPs.
review
highlights
functional
annotation
combined
manner.
Small,
Journal Year:
2024,
Volume and Issue:
20(26)
Published: Jan. 12, 2024
Abstract
Although
bioactive
compounds
(BCs)
have
many
important
functions,
their
applications
are
greatly
limited
due
to
own
defects.
The
development
of
nanocarriers
(NCs)
technology
has
gradually
overcome
the
defects
BCs.
NCs
equally
as
BCs
some
extent.
Self‐assembly
(SA)
methods
build
advantages
than
chemical
methods,
and
SA
significant
impact
on
structure
function
NCs.
However,
relationship
among
mechanism,
structure,
not
been
given
enough
attention.
Therefore,
from
perspective
bottom‐up
building
concept
SA‐structure‐function
is
emphasized
promote
SA‐based
First,
conditions
forces
for
occurring
introduced,
then
basis
molecular
mechanism
protein,
polysaccharide,
lipid
summarized.
Then,
varieties
structures
formed
based
introduced
in
detail.
Finally,
facing
how
be
well
solved
by
also
elaborated.
This
review
attempts
describe
great
significance
constructing
artificial
deliver
aspects
SA‐structure‐function,
so
wide
application
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(44), P. 10538 - 10565
Published: Jan. 1, 2023
Polysaccharides
have
found
extensive
utilization
as
biomaterials
in
drug
delivery
systems
owing
to
their
remarkable
biocompatibility,
simple
functionalization,
and
inherent
biological
properties.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(18), P. 3806 - 3806
Published: Sept. 12, 2022
Most
commercialized
wound
dressings
are
polymer-based.
Synthetic
and
natural
polymers
have
been
utilized
widely
for
the
development
of
dressings.
However,
use
is
limited
by
their
poor
mechanical
properties,
resulting
in
combination
with
synthetic
other
materials
to
enhance
properties.
Natural
mostly
affordable,
biocompatible,
biodegradable
promising
antimicrobial
activity.
They
further
tailored
into
unique
hybrid
when
combined
selected
biomaterials.
Some
important
features
required
an
ideal
dressing
include
capability
prevent
bacteria
invasion,
reduce
odor,
absorb
exudates,
be
comfortable,
facilitate
easy
application
removal
as
well
frequent
changing,
skin
tear
irritation
applied
or
removed,
provide
a
moist
environment
soothing
effect,
permeable
gases,
etc.
The
efficacy
design
cannot
overemphasized.
This
review
article
reports
prepared
from
polymers.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: June 30, 2022
Pathogenic
bacterial
infections
are
the
second
highest
cause
of
death
worldwide
and
bring
severe
challenges
to
public
healthcare.
Antibiotic
resistance
makes
it
urgent
explore
new
antibacterial
therapy.
As
an
essential
metal
element
in
both
humans
bacteria,
zinc
ions
have
various
physiological
biochemical
functions.
They
can
stabilize
folded
conformation
metalloproteins
participate
critical
reactions,
including
DNA
replication,
transcription,
translation,
signal
transduction.
Therefore,
deficiency
would
impair
activity
inhibit
growth
bacteria.
Interestingly,
excess
also
could
oxidative
stress
damage
DNA,
proteins,
lipids
by
inhibiting
function
respiratory
enzymes
promote
formation
free
radicals.
Such
dual
characteristics
endow
with
unparalleled
advantages
direction
Based
on
fascinating
features
ions,
nanomaterial-based
ion
interference
therapy
emerges
relying
outstanding
benefits
nanomaterials.
Zinc
is
divided
into
two
classes:
overloading
deprivation.
In
this
review,
we
summarized
recent
innovative
strategy
for
treatment
focused
analyzing
mechanism
Finally,
discuss
current
limitations
put
forward
problems
clinical
translation
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(5), P. 2912 - 2936
Published: Jan. 1, 2023
Copper(
i
)
catalyzed
alkyne
azide
cycloaddition
is
the
quintessential
example
of
‘Click
Chemistry’,
provides
an
adaptable
platform
for
synthesis
nanogels
sustained
drug
release
at
targeted
sites
owing
to
their
better
biocompatibility.
