Physiological Research,
Journal Year:
2023,
Volume and Issue:
72(3)
Published: June 30, 2023
Reactive
oxygen
species
(ROS)
are
small
reactive
molecules
produced
by
cellular
metabolism
and
regulate
various
physiological
pathological
functions.
Many
studies
have
shown
that
ROS
plays
an
essential
role
in
the
proliferation
inhibition
of
tumor
cells.
Different
concentrations
can
a
“double-edged
sword”
effect
on
occurrence
development
tumors.
A
certain
concentration
activate
growth-promoting
signals,
enhance
invasion
cells,
cause
damage
to
biomacromolecules
such
as
proteins
nucleic
acids.
However,
body's
antitumor
signal
at
higher
levels
initiating
oxidative
stress-induced
apoptosis
autophagy
This
review
analyzes
ROS's
unique
bidirectional
regulation
mechanism
focusing
key
signaling
pathways
regulatory
factors
affect
tumors
providing
ideas
for
in-depth
understanding
action
its
clinical
application.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 1, 2024
Abstract
Combining
existing
drug
therapy
is
essential
in
developing
new
therapeutic
agents
disease
prevention
and
treatment.
In
preclinical
investigations,
combined
effect
of
certain
known
drugs
has
been
well
established
treating
extensive
human
diseases.
Attributed
to
synergistic
effects
by
targeting
various
pathways
advantages,
such
as
reduced
administration
dose,
decreased
toxicity,
alleviated
resistance,
combinatorial
treatment
now
being
pursued
delivering
combat
major
clinical
illnesses,
cancer,
atherosclerosis,
pulmonary
hypertension,
myocarditis,
rheumatoid
arthritis,
inflammatory
bowel
disease,
metabolic
disorders
neurodegenerative
Combinatorial
involves
combining
or
co-delivering
two
more
for
a
specific
disease.
Nanoparticle
(NP)-mediated
delivery
systems,
i.e.,
liposomal
NPs,
polymeric
NPs
nanocrystals,
are
great
interest
wide
range
due
targeted
delivery,
extended
release,
higher
stability
avoid
rapid
clearance
at
infected
areas.
This
review
summarizes
targets
diseases,
clinically
approved
combinations
the
development
multifunctional
emphasizes
strategies
based
on
severe
Ultimately,
we
discuss
challenging
NP-codelivery
translation
provide
potential
approaches
address
limitations.
offers
comprehensive
overview
recent
cutting-edge
NP-mediated
combination
Molecules,
Journal Year:
2022,
Volume and Issue:
27(11), P. 3563 - 3563
Published: June 1, 2022
Antioxidants
have
drawn
the
attention
of
scientific
community
due
to
being
related
prevention
various
degenerative
diseases.
The
antioxidant
capacity
has
been
extensively
studied
in
vitro,
and
different
methods
used
assess
its
activity.
However,
main
issues
studying
natural
antioxidants
are
evaluating
whether
these
demonstrate
a
key
role
biological
system
assessing
their
bioavailability
organism.
majority
outcomes
literature
controversial
lack
method
standardization
proper
application.
Therefore,
this
study
aims
compile
concerning
field
study,
comparing
most
common
vitro
evaluate
activity
compounds,
demonstrating
systems
enzymes
redox
cellular
signaling
explaining
how
bioactive
compounds
is
evaluated
animal
models
human
clinical
trials.
Food Science & Nutrition,
Journal Year:
2023,
Volume and Issue:
12(2), P. 675 - 693
Published: Dec. 1, 2023
Abstract
Reactive
oxygen
species
(ROS)
are
produced
under
normal
physiological
conditions
and
may
have
beneficial
harmful
effects
on
biological
systems.
ROS
involved
in
many
processes
such
as
differentiation,
proliferation,
necrosis,
autophagy,
apoptosis
by
acting
signaling
molecules
or
regulators
of
transcription
factors.
In
this
case,
maintaining
proper
cellular
levels
is
known
redox
homeostasis.
Oxidative
stress
occurs
because
the
imbalance
between
production
antioxidant
defenses.
Sources
include
mitochondria,
auto‐oxidation
glucose,
enzymatic
pathways
nicotinamide
adenine
dinucleotide
phosphate
reduced
(NAD[P]H)
oxidase.
The
possible
NF‐κB,
MAPKs,
PI3K‐Akt,
Keap1‐Nrf2‐ARE
pathway.
This
review
covers
literature
pertaining
to
strategies
inhibit
them.
Additionally,
summarizes
related
finding
inhibitors.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(4)
Published: April 1, 2024
Abstract
Reactive
oxygen
species
(ROS)
constitute
a
spectrum
of
oxygenic
metabolites
crucial
in
modulating
pathological
organism
functions.
Disruptions
ROS
equilibrium
span
various
diseases,
and
current
insights
suggest
dual
role
for
tumorigenesis
the
immune
response
within
cancer.
This
review
rigorously
examines
production
its
normal
cells,
elucidating
subsequent
regulatory
network
inflammation
Comprehensive
synthesis
details
documented
impacts
on
diverse
cells.
Exploring
intricate
relationship
between
cancer
immunity,
we
highlight
influence
existing
immunotherapies,
including
checkpoint
blockade,
chimeric
antigen
receptors,
vaccines.
Additionally,
underscore
promising
prospects
utilizing
targeting
modulators
as
novel
immunotherapeutic
interventions
discusses
complex
interplay
ROS,
inflammation,
tumorigenesis,
emphasizing
multifaceted
functions
both
physiological
conditions.
It
also
underscores
potential
implications
immunotherapy
suggests
future
research
directions,
development
targeted
therapies
precision
oncology
approaches.
In
summary,
this
emphasizes
significance
understanding
ROS‐mediated
mechanisms
advancing
therapy
developing
personalized
treatments.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 7547 - 7566
Published: July 1, 2024
Abstract:
Cancer
poses
a
significant
threat
to
human
life
and
health.
Chemotherapy
is
currently
one
of
the
effective
cancer
treatments,
but
many
chemotherapy
drugs
have
cell
toxicity,
low
solubility,
poor
stability,
narrow
therapeutic
window,
unfavorable
pharmacokinetic
properties.
To
solve
above
problems,
target
drug
delivery
tumor
cells,
reduce
side
effects
drugs,
an
anti-tumor
system
based
on
microenvironment
has
become
focus
research
in
recent
years.
The
construction
reduction-sensitive
nanomedicine
disulfide
bonds
attracted
much
attention.
Disulfide
good
reductive
responsiveness
can
effectively
high
glutathione
(GSH)
levels
environment,
enabling
precise
delivery.
further
enhance
targeting
accelerate
release,
are
often
combined
with
pH-responsive
nanocarriers
highly
expressed
ligands
cells
construct
systems.
connect
molecules
polymer
system,
as
well
between
different
carrier
molecules.
This
article
summarized
systems
(DDS)
that
researchers
constructed
years
bond
microenvironment,
cleavage-triggering
conditions,
various
loading
strategies,
design.
In
this
review,
we
also
discuss
controlled
release
mechanisms
these
DDS
clinical
applicability
challenges
faced
translation.
Keywords:
bond,
systems,
GSH/ROS
Journal of Xenobiotics,
Journal Year:
2022,
Volume and Issue:
12(3), P. 214 - 222
Published: July 18, 2022
Infertility
is
a
severe
medical
problem
and
considered
serious
global
public
health
issue
affecting
large
proportion
of
humanity.
Oxidative
stress
one
the
most
crucial
factors
involved
in
infertility.
Recent
studies
indicate
that
overproduction
reactive
oxygen
species
(ROS)
or
nitrogen
(RNS)
may
cause
damage
to
male
female
reproductive
systems
leading
Low
amounts
ROS
RNS
are
essential
for
normal
functioning
systems,
such
as
sperm
motility,
acrosome
reaction,
interactions
with
oocytes,
ovulation,
maturation
follicles.
Environmental
heavy
metals
can
dysfunction
men
women
through
RNS.
It
suggested
oxidative
caused
by
arsenic
associated
disorders
alteration
counts
decreased
sex
hormones,
testis
ovary,
well
processes
spermatogenesis
oogenesis.
This
review
paper
highlights
relationship
between
arsenic-induced
prevalence
infertility,
detailed
explanations
potential
underlying
mechanisms.
International Journal of Cancer,
Journal Year:
2023,
Volume and Issue:
153(5), P. 918 - 931
Published: Feb. 27, 2023
Abstract
Oncogene‐induced
hyper‐proliferation
in
cancer
cells
is
accompanied
by
the
onset
of
different
stresses,
including
DNA‐replication
stress,
metabolic
stress
and
oxidative
stress.
Excessive
accumulation
reactive
oxygen
species
(ROS)
plays
a
pivotal
contradictory
role
tumor
progression.
ROS
dictates
multitude
cell
signaling
pathways
to
facilitate
malignant
transformation
cells.
In
meantime,
burden
mandates
reinforcing
antioxidant
capacity
mitigate
detrimental
damages.
The
addiction
increased
iron
demands
also
impinges
on
sensitivity
ferroptosis.
Targeting
redox
homeostasis
ferroptosis
overcome
drug
resistance
treatment
has
become
an
attractive
research
topic.
However,
roles
oncogenic
regulation
have
not
been
comprehensively
discussed.
this
review,
we
summarize
current
knowledge
regarding
interplay
between
context
biology.
We
emphasize
implication
regulation.
provide
overview
strategies
targeting
treatment.
Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(4), P. 104629 - 104629
Published: Jan. 30, 2023
Carapa
guianensis
is
a
tree
from
Meliaceae
family
traditionally
known
as
andiroba
that
has
wide
range
of
biological
properties,
including
therapeutic
effects,
antioxidant
activities,
insecticidal
and
repellent
effects
can
be
used
in
biotechnological
approaches
to
medicine,
agriculture,
cosmetic
products.
Therefore,
we
aim
explore
the
activities
exhibited
by
this
species
their
respective
applications
interest.
For
this,
systematic
review
was
carried
out
following
PRISMA
guidelines
dated
1993
2022
through
Scopus,
Web
Science
Agricultural
Research
Database
(Base
de
Dados
da
Pesquisa
Agropecuária
-
BDPA),
screened
for
activity/bioactive
compounds.
A
total
129
studies
were
included
flow
analysis.
Biological
properties
major
bioactive
compounds,
well
could
identified.
The
activity
C.
observed
different
vegetative
parts
diverse
methods
extractions.
These
are
mainly
due
unsaturated
fatty
acids
such
limonoids
small
fraction
phenolic
Gedunin-type
limonoids,
like
gedunin
its
derivatives,
represent
class
compounds
show
highest
bioactivities
applications.
