Bioinformatics analysis and identification of upregulated tumor suppressor genes associated with suppressing colon cancer progression by curcumin treatment DOI Creative Commons
Dan Wu,

Zhenkai Fu,

Wenna Liu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 5, 2023

Tumor suppressor genes (TSGs) are commonly downregulated in colon cancer and play a negative role tumorigenesis progression by affecting genomic integrity, the cell cycle, proliferation. Curcumin (CUR), Chinese herb-derived phytochemical, exerts antitumor effects on cancer. However, it remains unclear whether CUR its reactivating TSGs Here, we demonstrated that inhibited HT29 HCT116 proliferation migration cell-counting kit-8, colony-formation, wound-healing assays. Furthermore, comprehensive bioinformatics analysis of mRNA sequencing revealed 3,505 were significantly upregulated response to cells. Kyoto Encyclopedia Genes Genomes Gene Ontology analyses showed most enriched pathways containing 37 TSGs. Five ( ARHGEF12 , APAF1 VHL CEBPA CASP8 ) randomly selected for real-time fluorescence polymerase chain reaction verification results these five reactivated after treatment, suggesting related CUR-mediated inhibition. is newly identified TSG potential therapeutic target molecular docking was performed predict binding sites ARHGEF12, can prevent invasion metastasis inhibiting RhoA binding. In conclusion, present study reveals inhibits TSGs, revealing new mechanism treatment.

Language: Английский

Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil DOI
Zhongming Yang, Carlos L. Céspedes, Zhongguo Yang

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

Citations

6
Substances of Natural Origin in Medicine: Plants vs. Cancer DOI Creative Commons
Adrianna Gielecińska, Mateusz Kciuk, Somdutt Mujwar

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(7), P. 986 - 986

Published: March 23, 2023

Continuous monitoring of the population’s health is main method learning about disease prevalence. National and international data draw attention to persistently high rates cancer incidence. This necessitates intensification efforts aimed at developing new, more effective chemotherapeutic chemopreventive drugs. Plants represent an invaluable source natural substances with versatile medicinal properties. Multidirectional activities exhibited by their ability modulate key signaling pathways, mainly related cell death, make these important research direction. review summarizes information regarding plant-derived drugs, including mechanisms action, a special focus on selected anti-cancer drugs (paclitaxel, irinotecan) approved in clinical practice. It also presents promising plant-based drug candidates currently being tested preclinical trials (betulinic acid, resveratrol, roburic acid).

Language: Английский

Citations

35
Resveratrol Modulates Chemosensitisation to 5-FU via β1-Integrin/HIF-1α Axis in CRC Tumor Microenvironment DOI Open Access
Aranka Brockmueller, Sosmitha Girisa, Ajaikumar B. Kunnumakkara

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4988 - 4988

Published: March 5, 2023

Frequent development of resistance to chemotherapeutic agents such as 5-flourouracil (5-FU) complicates the treatment advanced colorectal cancer (CRC). Resveratrol is able utilize β1-integrin receptors, strongly expressed in CRC cells, transmit and exert anti-carcinogenic signals, but whether it can also these receptors overcome 5-FU chemoresistance cells has not yet been investigated. Effects knockdown on anti-cancer capabilities resveratrol were investigated HCT-116 5-FU-resistant HCT-116R tumor microenvironment (TME) with 3D-alginate well monolayer cultures. increased cell sensitivity by reducing TME-promoted vitality, proliferation, colony formation, invasion tendency mesenchymal phenotype including pro-migration pseudopodia. Furthermore, impaired favor more effective utilization down-regulating TME-induced inflammation (NF-kB), vascularisation (VEGF, HIF-1α) stem production (CD44, CD133, ALDH1), while up-regulating apoptosis (caspase-3) that was previously inhibited TME. These mechanisms largely abolished antisense oligonucleotides against (β1-ASO) both lines, indicating particular importance for 5-FU-chemosensitising effect resveratrol. Lastly, co-immunoprecipitation tests showed targets modulates TME-associated β1-integrin/HIF-1α signaling axis cells. Our results suggest first time utility related chemosensitization overcoming resveratrol, underlining its potential supportive applications treatment.

Language: Английский

Citations

25
Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy DOI Creative Commons
Aranka Brockmueller, Vicenç Ruiz de Porras, Mehdi Shakibaei

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3525 - 3551

Published: May 3, 2024

Abstract Colorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy an evolutionarily highly conserved degradation pathway involved in a variety processes, such as maintenance homeostasis clearance foreign bodies, its imbalance associated with many diseases. However, role autophagy CRC progression remains controversial, it has dual function, affecting either or survival, senescence tumor therapy. Indeed, numerous data have been presented that serves alternative apoptosis when latter ineffective apoptosis‐resistant cells, which why also referred programmed type II. Curcumin, active constituents Curcuma longa , great potential combat influencing various signaling pathways epigenetic regulation safe cost‐effective approach. This review discusses efficacy curcumin against vitro vivo, particularly modulation pathways. While clinical studies assessed prevention treatment, none specifically examined Nonetheless, we offer overview correlations support use this polyphenol prophylactic co‐therapeutic agent CRC.

Language: Английский

Citations

7
Curcumin and its novel formulations for the treatment of hepatocellular carcinoma: New trends and future perspectives in cancer therapy DOI Creative Commons
Seyed Mohammadmahdi Meybodi,

Pouria Rezaei,

Niki Faraji

et al.

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 108, P. 105705 - 105705

Published: Aug. 5, 2023

Hepatocellular carcinoma (HCC), as a common malignancy of the liver, is second leading cause cancer-related death in world and mostly occurs patients with background chronic liver disease. Patents this represent various signs symptoms, such splenomegaly, peripheral edema, jaundice. More than 70 % HCC cases are advanced stage because lacking diagnostic systems indications early stages, therefore giving rise to high lethality rate involved patients. Against malignancy, several therapeutic methods have been recommended, like surgical resection, immunotherapy, transplantation, chemotherapeutic drugs (e.g., doxorubicin, mitomycin C, cisplatin); however, these curative modalities not created serious hope for patents. Nowadays, herbal medicine natural compounds has offered different illnesses, cancer. Among these, some components their nano-based formulations, especially curcumin (a polyphenol extract Curcuma longa), become point interest treating HCC. Hence, review aimed evaluate anticancer effects its biological potential based on current documents.

Language: Английский

Citations

12
Resveratrol and p53: How are they involved in CRC plasticity and apoptosis? DOI Creative Commons
Aranka Brockmueller, Constanze Buhrmann, Amir Reza Moravejolahkami

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: 66, P. 181 - 195

Published: Jan. 6, 2024

Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle factors, very often associated with functional plasticity during its development. In addition, the malignant of CRC cells underscores one their survival abilities to functionally adapt specific stresses, including inflammation, that occur carcinogenesis. This leads generation various subsets phenotypic diversity promotes epithelial-mesenchymal transition (EMT), formation cell stem (CSC) metabolic reprogramming. can enhance differentiation facilitate tumorigenic potential, drug resistance metastasis. The tumor protein p53 acts as central suppressors carcinogenesis regulating target genes, whose proteins are involved in cells, autophagy, cycle, apoptosis, DNA repair. aim this review summarize latest published research on resveratrol's effect prevention CRC, regulatory actions, specifically pathway, treatment options. Resveratrol, a naturally occurring polyphenol, potent inducer variety tumor-controlling. However, underlying mechanisms linking signaling pathway anti-plasticity resveratrol still poorly understood. Therefore, discusses novel relationships between anti-cellular plasticity/heterogeneity, pro-apoptosis modulation oncogenesis, crucial prevents changes leading migration resistance, thus improving ongoing CRC.

Language: Английский

Citations

4
Hsa-miR-526b-5p Regulates the Sensitivity of Colorectal Cancer to 5-Fluorouracil by Targeting TP53 in Organoid Models DOI
Leaf Huang, Cun Liao,

Zuming Xiong

et al.

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Language: Английский

Citations

0
The Potential Benefits of Curcumin-Enriched Diets for Adults with Colorectal Cancer: A Systematic Review DOI Creative Commons

María Neira,

Carlos F. Mena, Keila Torres

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 388 - 388

Published: March 26, 2025

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Conventional treatments such as chemotherapy and radiotherapy are often associated with severe side effects limited effectiveness. Curcumin, a polyphenol derived from Curcuma longa, has demonstrated anti-inflammatory anticancer properties. A systematic review recent scientific literature followed PRISMA guidelines to evaluate benefits curcumin-enriched diet for adults colorectal cancer. Articles published between 2018 2024 were retrieved PubMed, SciELO, Google Scholar, Scopus. Studies meeting inclusion criteria focused on curcumin, adults, outcomes. The administration curcumin-containing products was improved survival rates, enhanced quality life, tumor reduction, effects. shows potential an effective adjunct therapy CRC patients, though its bioavailability effects, gastrointestinal discomfort, pose challenges. Addressing these limitations through larger cohorts, extended study durations, formulations enhance essential. Such efforts could enable development personalized dietary recommendations management.

Language: Английский

Citations

0
Modulating the gut microbiota: A novel perspective in colorectal cancer treatment DOI
Xue Bai,

Boyang Liu,

Daiming Fan

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217459 - 217459

Published: Jan. 1, 2025

Language: Английский

Citations

0
Calebin A targets the HIF-1α/NF-κB pathway to suppress colorectal cancer cell migration DOI Creative Commons
Aranka Brockmueller, Sosmitha Girisa, Mahzad Motallebi

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: July 31, 2023

Background: Hypoxia-inducible factor-1α (HIF-1α) is one of the major tumor-associated transcription factors modulating numerous tumor properties such as cell metabolism, survival, proliferation, angiogenesis, and metastasis. Calebin A (CA), a compound derived from turmeric, known for its anti-cancer activity through modulation NF-κB pathway. However, impact on HIF-1α in colorectal cancer (CRC) migration unknown. Methods: Human CRC cells (HCT-116) 3D alginate monolayer multicellular TME (fibroblasts/T lymphocytes) were subjected to CA or inhibitor explore efficacy TME-induced inflammation, migration, malignancy. Results: significantly inhibited TME-promoted proliferation HCT-116 cells, similar inhibitor. Colony formation, toluidine blue staining, immunolabeling showed that partly by inhibiting HIF-1α, which critical viability, these observations confirmed electron microscopy. In addition, Western blot analysis TME-initiated expression biomarkers metastatic (such NF-κB, β1-integrin, VEGF), promoted apoptosis (caspase-3), manner comparable Finally, induced purposeful pairing between suggesting synergistic interplay two essential malignancy silences tandem. Conclusion: These results shed light novel regulatory signaling partially via HIF-1α/NF-κB with potentially relevant implications therapy.

Language: Английский

Citations

8