Role of natural products in tumor therapy from basic research and clinical perspectives

Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(2)

Published: Jan. 1, 2024

Cancer is the leading cause of morbidity and mortality worldwide an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally increasing numbers natural approved for clinical studies involving cancer recent years. To gain more insight into that have undergone trials treatment, a comprehensive search was conducted. The https://clinicaltrials.gov website searched relevant product information up December 2022. terms included different types cancers, such as colorectal, lung, breast, gynecologic, kidney, bladder, melanoma, pancreatic, hepatocellular, gastric haematologic. Then, PubMed Web Science were articles February 2024. Hence, we listed existing about used treatment cancers discussed preclinical some promising their targets, indications, underlying mechanisms action. Our intent provide basic readers who interested or majoring obtain deeper understanding progress actions

Language: Английский

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Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

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Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101004 - 101004

Published: Aug. 21, 2023

Language: Английский

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Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2056 - 2056

Published: Nov. 29, 2023

Cancer is one of the most serious public health issues worldwide, demanding ongoing efforts to find novel therapeutic agents and approaches. Amid growing interest in oncological applications phytochemicals, particularly polyphenols, resveratrol-a naturally occurring polyphenolic stilbene derivative-has emerged as a candidate interest. This review analyzes pleiotropic anti-cancer effects resveratrol, including its modulation apoptotic pathways, cell cycle regulation, inflammation, angiogenesis, metastasis, interaction with cancer stem cells tumor microenvironment. The resveratrol on mitochondrial functions, which are crucial development, also discussed. Future research directions identified, elucidation specific molecular targets, facilitate clinical translation prevention therapy.

Language: Английский

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Resveratrol as sensitizer in colorectal cancer plasticity

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 43(1), P. 55 - 85

Published: July 29, 2023

Abstract Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that be linked several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition the sentinel gene p53, apoptosis. As consequence, tumor cells escape effectiveness chemotherapeutic agents. This underscores need for cross-target therapeutic approaches are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize overcome standard drugs. In recent years, scientists have been searching natural compounds used chemosensitizers addition conventional medications synergistic CRC. Resveratrol, polyphenolic phytoalexin found various fruits vegetables such peanuts, berries, red grapes, is one most effective chemopreventive Abundant vitro vivo studies shown resveratrol, interaction with drugs, chemosensitizer CRC agents thus prevents drug by modulating pathways, transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, The ability resveratrol modify subcellular may suppress plasticity reversal critical parameters understanding its anti-cancer effects. this review, we focus on chemosensitizing properties and, thus, potential importance additive ongoing treatments. Graphical abstract

Language: Английский

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Resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and Sirt-1 in the CRC tumor microenvironment

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 27, 2023

Introduction P53 represents a key player in apoptosis-induction cancers including colorectal cancer (CRC) that ranks third worldwide prevalence as well mortality statistics. Although pro-apoptotic effect of resveratrol has been repeatedly proven CRC cells, its pathway mechanisms are not completely understood, there controversial statements the literature regarding activation or inhibition counteracting proteins Sirt-1 and p53. Methods cells wild-type (HCT-116 WT) p53-deficient p53 -/- ) were cultured using multicellular tumor microenvironment (TME) cultures containing T-lymphocytes fibroblasts to elucidate role p53/Sirt-1 modulation resveratrol’s concentration-dependent, pro-apoptotic, thus anti-cancer effects. Results Resveratrol dose-dependently inhibited viability, proliferation, plasticity migration, induced apoptosis HCT-116 WT more effectively than cells. Moreover, stimulated expression when administered at low concentrations (<5µM) but suppressed it added high (>10µM) CRC-TME. In parallel, similar knockdown mRNA level, treatment with high-concentration boosted acetylation p53, p21, Bax, cytochrome C, caspase-3, ultimately Notably, increasing found promote hyperacetylation FOXO3a post-translational substrates Sirt-1, indicating negative regulatory loop between Discussion These results demonstrate for first time, reciprocal crosstalk circuits consequently, induction by higher

Language: Английский

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Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 326 - 326

Published: Feb. 24, 2025

Colorectal cancer (CRC) is one of the deadliest neoplasia. Intrinsic or acquired resistance main cause failure therapy regimens that leads to relapse and death in CRC patients. The widely used chemotherapeutic agent 5-fluorouracil (5-FU) remains mainstay for therapeutic combinations. Unfortunately, side effects are frequent events compromise success these therapies; dysregulation enzymes regulate 5-FU metabolism increases expression activity efflux pumps. Additional tumor cell adaptations such as epithelial–mesenchymal transition (EMT), autophagy shaping microenvironment, inflammation contribute chemoresistance. Finding new strategies alternatives enhance conventional chemotherapies has become necessary. Recently, study natural compounds been gaining strength an alternative chemotherapeutics different cancers. Curcumin, trimethylglycine, resveratrol, artemisinin, some helminth-derived molecules, among others, studied context CRC. This review discusses benefits, mechanisms, advances, dark currently evaluated treatment. We also analyzed landscape non-conventional their underlying mechanisms action, which could, short term, provide fundamental knowledge harness anti-tumor allow them be adjuvant therapies.

Language: Английский

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Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 10, 2023

One of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms action favor cell survival proliferation, becoming one leading causes failure against A promising strategy overcome chemoresistance radioresistance co-administration anticancer agents natural compounds with properties, such as polyphenolic compound resveratrol (RSV). RSV has been reported able sensitize chemotherapeutic radiotherapy, promoting death. This review describes molecular by which sensitizes tumor radiotherapy chemotherapy treatment.

Language: Английский

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Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 43(1), P. 87 - 113

Published: Oct. 4, 2023

Abstract Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis is implicated the multiple cancer defense mechanisms associated with therapy resistance evasion. represents one of significant obstacles clinical management cancer. Some reversal chemosensitizing agents have been developed to resolve this serious problem, but they not yet proven applicable oncological practice. Activated nuclear factor kappa B (NF-κB) frequently observed biomarker chemoresistant breast (BC). Therefore, it denotes an attractive cellular target mitigate resistance. We summarize that flavonoids represent essential class phytochemicals act as regulators NF-κB signaling negatively affect fundamental processes contributing acquired drug In regard, flavokawain A, icariin, alpinetin, genistein, wogonin, apigenin, oroxylin xanthohumol, EGCG, hesperidin, naringenin, orientin, luteolin, delphinidin, fisetin, norwogonin, curcumin, cardamonin, methyl gallate catechin-3-O-gallate, ampelopsin, puerarin, hyperoside, baicalein, paratocarpin E, kaempferol also synthetic such LFG-500 5,3′-dihydroxy-3,6,7,8,4′-pentamethoxyflavone reported specifically interfere pathway complex consequences BC cells could be potentially re-sensitizing unresponsive cases. The targeting by above-mentioned includes modification microenvironment epithelial-mesenchymal transition, growth receptor regulations, modulations specific pathways PI3K/AKT, MAP kinase/ERK, Janus kinase/signal transduction cells. Besides that, modulated has involved regulation ATP-binding cassette transporters, apoptosis, autophagy, cycle, changes activity stem cells, oncogenes, or controlling gene repair. evaluation conventional therapies combination plasticity-regulating/sensitizing offers new opportunities make progress towards complete cure for Graphical abstract

Language: Английский

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Natural Products Treat Colorectal Cancer by Regulating miRNA

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1122 - 1122

Published: Aug. 9, 2023

Diseases are evolving as living standards continue to improve. Cancer is the main cause of death and a major public health problem that seriously threatens human life. Colorectal cancer one top ten most common malignant tumors in China, ranking second after gastric among gastrointestinal tumors, its incidence rate increasing dramatically each year due changes dietary habits lifestyle world’s population. Although conventional therapies, such surgery, chemotherapy, radiotherapy, have profoundly impacted treatment colorectal (CRC), drug resistance toxicity remain substantial challenges. Natural products, therapeutic agents, considered safest alternative for treating CRC. In addition, there evidence natural products can induce apoptosis, inhibit cell cycle arrest, reduce invasion migration colon cells by targeting regulating expression function miRNAs. Here, we summarize recent research findings on miRNA-regulation-based antitumor mechanisms various active ingredients highlighting how target miRNA regulation prevention treatment. The application delivery systems predictive disease biomarkers also discussed. Such approaches will contribute discovery new regulatory associated with pathways provide theoretical basis developing novel drugs compounds identifying targets.

Language: Английский

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