Toxics,
Journal Year:
2024,
Volume and Issue:
12(8), P. 531 - 531
Published: July 23, 2024
Nanoplastics
(NPs)
cause
serious
contamination
of
drinking
water
and
potential
damage
to
human
health.
This
study
aimed
investigate
the
effects
NPs
with
different
particle
sizes
concentrations
on
reproductive
function
male
mice.
In
this
study,
free
exposure
was
used
expose
BALB/C
mice
PS-NPs
(20
nm,
200
1000
nm)
at
0.1
mg/L,
1
5
mg/L
for
4
months.
The
assessed
after
exposure,
fecal
blood
samples
were
collected
macrogenomics
metabolomics.
results
showed
that
resulted
in
reduced
testicular
organ
coefficients,
decreased
sperm
quality,
altered
tissue
structure,
disturbed
sex
hormone
levels,
abnormal
levels
inflammatory
factors
oxidative
stress.
Furthermore,
found
NP
affected
alteration
gut
communities
metabolic
pathways
related
reproduction,
such
as
Clostridium
glutathione
metabolism.
Importantly,
we
an
effect
size
function.
future,
more
attention
should
be
paid
smaller
NPs.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7544 - 7544
Published: July 9, 2024
Ferroptosis
is
a
type
of
nonapoptotic
cell
death
that
characteristically
caused
by
phospholipid
peroxidation
promoted
radical
reactions
involving
iron.
Researchers
have
identified
many
the
protein
factors
are
encoded
genes
promote
ferroptosis.
Glutathione
peroxidase
4
(GPX4)
key
enzyme
protects
phospholipids
from
and
suppresses
ferroptosis
in
glutathione-dependent
manner.
Thus,
dysregulation
involved
cysteine
and/or
glutathione
metabolism
closely
associated
with
From
perspective
dynamics,
actively
proliferating
cells
more
prone
to
than
quiescent
cells,
which
suggests
species
generated
during
oxygen-involved
responsible
for
lipid
peroxidation.
Herein,
we
discuss
initial
events
dominantly
occur
process
energy
metabolism,
association
deficiency.
Accordingly,
tricarboxylic
acid
cycle
coupled
respiratory
chain
mitochondria
main
subjects
here,
this
likely
source
both
electrons
free
Since
not
only
carbohydrates,
but
also
amino
acids,
especially
glutamate,
major
substrates
central
dealing
nitrogen
derived
groups
contributes
subject
discussion.
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 31, 2024
Abstract
In
women
who
are
getting
older,
the
quantity
and
quality
of
their
follicles
or
oocytes
decline.
This
is
characterized
by
decreased
ovarian
reserve
function
(DOR),
fewer
remaining
oocytes,
lower
oocytes.
As
more
choose
to
delay
childbirth,
decline
in
fertility
associated
with
age
has
become
a
significant
concern
for
modern
women.
The
oocyte
key
indicator
aging.
Many
studies
suggest
that
age-related
changes
energy
metabolism
may
impact
quality.
Changes
affect
adenosine
5'-triphosphate
(ATP)
production,
but
how
related
products
proteins
influence
remains
largely
unknown.
review
focuses
on
aging
its
potential
quality,
as
well
therapeutic
strategies
partially
metabolism.
research
aims
enhance
our
understanding
metabolism,
identification
biomarkers
treatment
methods.
International Journal of Biological Sciences,
Journal Year:
2025,
Volume and Issue:
21(4), P. 1837 - 1851
Published: Feb. 10, 2025
Radiotherapy
is
the
primary
treatment
for
nasopharyngeal
carcinoma
(NPC);
nonetheless,
radioresistance
remains
leading
cause
of
localized
recurrence.
Our
study
demonstrates
a
significant
increase
in
N6-methyladenosine
(m6A)
methylase
METTL3
NPC
and
other
tumors.
Mechanistically,
acts
as
an
m6A
methylase,
enhancing
modification
solute
carrier
family
7
member
11
(SLC7A11)
transcript,
which
increases
its
stability
expression,
thereby
inhibiting
radiation-induced
ferroptosis
ultimately
inducing
NPC.
Furthermore,
silencing
SLC7A11
or
employing
inducer
Erastin
negated
promoting
effect
on
cell
radioresistance.
These
findings
suggest
that
could
be
novel
therapeutic
target
overcoming
radiotherapy
resistance
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(5), P. 597 - 597
Published: May 13, 2024
Oxidative
stress
occurs
when
there
is
an
imbalance
between
the
production
of
reactive
oxygen
species
(ROS)
and
body’s
antioxidant
defenses.
It
poses
a
significant
threat
to
physiological
function
reproductive
cells.
Factors
such
as
xenobiotics
heat
can
worsen
this
stress,
leading
cellular
damage
apoptosis,
ultimately
decreasing
efficiency.
The
nuclear
factor
erythroid
2–related
2
(Nrf2)
signaling
pathway
plays
crucial
role
in
defending
against
oxidative
protecting
cells
via
enhancing
responses.
Dysregulation
Nrf2
has
been
associated
with
infertility
suboptimal
performance
mammals.
Recent
advancements
therapeutic
interventions
have
underscored
critical
mitigating
restoring
functional
integrity
In
narrative
review,
we
delineate
harmful
effects
xenobiotic-induced
on
explain
how
provides
protection
these
challenges.
studies
shown
that
activating
using
various
bioactive
compounds
ameliorate
distress
apoptosis
mammalian
By
comprehensively
analyzing
existing
literature,
propose
key
target
for
caused
by
exposure
xenobiotic
stress.
Additionally,
based
synthesis
findings,
discuss
potential
therapies
focused
improve
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 15, 2024
Spermidine
(SPD)
is
an
intermediate
compound
in
the
polyamine
metabolism
which
takes
critical
part
a
variety
of
cellular
processes.
In
particular,
it
has
been
reported
to
exert
anti-aging
effects,
suppress
age-related
diseases,
and
extend
lifespan
across
species.
However,
whether
favorable
influence
on
quality
postovulatory
aged
oocytes
remains
elusive.
