International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(17), P. 6344 - 6344
Published: Sept. 1, 2020
Abnormal
tau
protein
aggregation
in
the
brain
is
a
hallmark
of
tauopathies,
such
as
frontotemporal
lobar
degeneration
and
Alzheimer’s
disease.
Substantial
evidence
has
been
linking
to
neurodegeneration,
but
underlying
mechanisms
have
yet
be
clearly
identified.
Mitochondria
are
paramount
organelles
neurons,
they
provide
main
source
energy
(adenosine
triphosphate)
these
highly
energetic
cells.
Mitochondrial
dysfunction
was
identified
an
early
event
neurodegenerative
diseases
occurring
even
before
cognitive
deficits.
Tau
shown
interact
with
mitochondrial
proteins
impair
bioenergetics
dynamics,
leading
neurotoxicity.
In
this
review,
we
discuss
detail
different
impacts
disease-associated
on
functions,
including
transport,
network
mitophagy
bioenergetics.
We
also
give
new
insights
about
effects
abnormal
neurosteroidogenesis,
well
endoplasmic
reticulum-mitochondria
coupling.
A
better
understanding
pathomechanisms
tau-induced
failure
may
help
identify
targets
for
therapeutic
interventions.
Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
243, P. 113972 - 113972
Published: Aug. 24, 2022
Parkinson's
disease
(PD)
is
a
neurodegenerative
disorder
which
mainly
targets
motor
symptoms
such
as
tremor,
rigidity,
bradykinesia
and
postural
instability.
The
physiological
changes
occur
due
to
dopamine
depletion
in
basal
ganglia
region
of
the
brain.
PD
aetiology
not
yet
elucidated
clearly
but
genetic
environmental
factors
play
prominent
role
occurrence.
Despite
various
factors,
pesticides
exposure
has
been
convicted
major
candidate
pathogenesis.
Among
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)
widely
investigated
following
with
paraquat
(PQ),
maneb
(MB),
organochlorines
(OC)
rotenone.
Effect
these
suggested
be
involved
oxidative
stress,
alterations
transporters,
mitochondrial
dysfunction,
α-synuclein
(αSyn)
fibrillation,
neuroinflammation
PD.
present
review
discusses
influence
neurodegeneration
its
related
epidemiological
studies
conducted
Furthermore,
we
have
deliberated
common
associated
probable
mechanism
them
behind
Hence,
conclude
that
pathogenesis
advance
research
needed
investigate
mechanistic
aspects
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(16), P. 9328 - 9328
Published: Aug. 19, 2022
The
distinguishing
pathogenic
features
of
neurodegenerative
diseases
include
mitochondrial
dysfunction
and
derived
reactive
oxygen
species
generation.
neural
tissue
is
highly
sensitive
to
oxidative
stress
this
a
prominent
factor
in
both
chronic
acute
neurodegeneration.
Based
on
this,
therapeutic
strategies
using
antioxidant
molecules
towards
redox
equilibrium
have
been
widely
used
for
the
treatment
several
brain
pathologies.
Globally,
polyphenols,
carotenes
vitamins
are
among
most
typical
exogenous
agents
that
tested
neurodegeneration
as
adjunctive
therapies.
However,
other
types
antioxidants,
including
hormones,
such
melatonin,
also
considered
neuroprotective
different
contexts.
This
review
highlights
relevant
targets
main
disorders
Alzheimer's
disease,
Parkinson's
Huntington's
disease
less
represented
amyotrophic
lateral
sclerosis,
well
traumatic
injury,
while
summarizing
latest
randomized
placebo-controlled
trials.
Frontiers in Cellular Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: March 6, 2023
Neuronal
loss
is
one
of
the
striking
causes
various
central
nervous
system
(CNS)
disorders,
including
major
neurodegenerative
diseases,
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
Huntington’s
(HD),
and
Amyotrophic
lateral
sclerosis
(ALS).
Although
these
diseases
have
different
features
clinical
manifestations,
they
share
some
common
mechanisms
pathology.
Progressive
regional
neurons
in
patients
responsible
for
motor,
memory,
cognitive
dysfunctions,
leading
to
disabilities
death.
cell
death
linked
pathways
conditions.
Protein
misfolding
aggregation,
mitochondrial
dysfunction,
generation
reactive
oxygen
species
(ROS),
activation
innate
immune
response
are
most
critical
hallmarks
diseases.
Thus,
endoplasmic
reticulum
(ER)
stress,
oxidative
neuroinflammation
pathological
factors
neuronal
Even
though
exact
not
fully
discovered,
notable
role
mentioned
well
known.
On
this
basis,
researchers
been
prompted
investigate
neuroprotective
effects
targeting
underlying
determine
a
promising
therapeutic
approach
treatment.
This
review
provides
an
overview
ER
death,
mainly
discussing
or
molecules
involved
factors.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(3), P. 1987 - 2026
Published: March 2, 2024
Mitochondria
are
thought
to
have
become
incorporated
within
the
eukaryotic
cell
approximately
2
billion
years
ago
and
play
a
role
in
variety
of
cellular
processes,
such
as
energy
production,
calcium
buffering
homeostasis,
steroid
synthesis,
growth,
apoptosis,
well
inflammation
ROS
production.
Considering
that
mitochondria
involved
multitude
mitochondrial
dysfunction
has
been
shown
several
age-related
diseases,
including
cancers,
diabetes
(type
2),
neurodegenerative
although
underlying
mechanisms
not
entirely
understood.
The
significant
increase
lifespan
increased
incidence
diseases
over
recent
decades
confirmed
necessity
understand
by
which
impacts
process
aging
diseases.
In
this
review,
we
will
offer
brief
overview
mitochondria,
along
with
structure
function
important
organelle.
We
then
discuss
cause
consequence
process,
particular
focus
on
its
inflammation,
cognitive
decline,
Huntington’s
disease,
Parkinson’s
Alzheimer’s
disease.
insight
into
therapies
interventions
currently
used
preserve
or
restore
functioning
during
neurodegeneration.
Exploration,
Journal Year:
2021,
Volume and Issue:
1(3)
Published: Dec. 1, 2021
Abstract
Neurodegenerative
diseases
(NDs)
are
a
class
of
heterogeneous
that
includes
Alzheimer's
disease,
Parkinson's
Huntington's
and
amyotrophic
lateral
sclerosis.
Mitochondria
play
an
important
role
in
oxidative
balance
metabolic
activity
neurons;
therefore,
mitochondrial
dysfunction
is
associated
with
NDs
mitochondria
considered
potential
treatment
target
for
NDs.
Several
obstacles,
including
the
blood‐brain
barrier
(BBB)
cell/mitochondrial
membranes,
reduce
efficiency
drug
entry
into
lesions.
Therefore,
variety
neuron
targeting
strategies
has
been
developed.
Among
them,
nanotechnology‐based
treatments
show
especially
promising
results.
Owing
to
their
adjustable
size,
appropriate
charge,
lipophilic
surface,
nanoparticles
(NPs)
ideal
theranostic
system
crossing
BBB
neuronal
mitochondria.
In
this
review,
we
discussed
dysfunctional
ND
pathogenesis
as
well
physiological
barriers
various
strategies.
We
also
reviewed
use
advantages
NPs
(including
organic,
inorganic,
biological
membrane‐coated
NPs)
diagnosis
Finally,
summarized
evidence
possible
NP‐based
systems
dysfunction‐related
