Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 100975 - 100975
Published: Jan. 26, 2024
Diabetic
wound
healing
is
delayed
due
to
persistent
inflammation,
and
macrophage-immunomodulating
biomaterials
can
control
the
inflammatory
phase
shorten
time.
In
this
study,
acellular
embryoid
bodies
(aEBs)
were
prepared
mixed
with
thermosensitive
hydroxybutyl
chitosan
(HBC)
hydrogels
produce
aEB/HBC
composite
hydrogels.
The
exhibited
reversible
temperature-sensitive
transition
behavior
a
hybrid
porous
network.
vitro
analysis
showed
that
better
antimicrobial
activity
than
PBS
control,
aEBs
or
HBC
promoted
M0
M2
polarization
but
not
M1
macrophage
repolarization
in
culture.
vivo
results
accelerated
cutaneous
closure,
re-epithelialization,
ingrowth
of
new
blood
vessels,
collagen
deposition
reduced
scar
width
during
diabetic
mice
over
Macrophage
phenotype
induce
reactions
continually,
upregulate
M2-related
mRNA
protein
expression
downregulate
M1-related
expression.
Therefore,
have
excellent
activity,
promote
accelerate
functional
structural
wounds.
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 123 - 123
Published: Feb. 7, 2025
Recent
advancements
in
wound
dressing
materials
have
significantly
improved
acute
and
chronic
management
by
addressing
challenges
such
as
infection
control,
moisture
balance,
enhanced
healing.
Important
progress
has
been
made,
especially
with
hydrogels,
foams,
antimicrobial
for
creating
optimized
dressings.
Hydrogels
are
known
maintaining
optimal
levels,
while
foam
dressings
excellent
exudate
absorbents.
Meanwhile,
incorporates
various
agents
to
reduce
risks.
These
options
healing
time
focusing
on
customized
patient
needs.
Therefore,
this
review
highlights
the
newest
research
prototypes
applications,
emphasizing
their
particular
benefits
clinical
importance.
Innovations
stimuli-responsive
hydrogels
hybrid
bioengineered
composites
discussed
relation
properties,
including
responsiveness
pH,
temperature,
glucose,
or
enzymes
drug
delivery
precision.
Moreover,
ongoing
trials
included,
demonstrating
potential
of
emerging
solutions
be
soon
translated
from
laboratory
settings.
By
discussing
interdisciplinary
approaches
that
integrate
advanced
materials,
nanotechnology,
biological
insights,
work
provides
a
contemporary
framework
patient-centric,
efficient
care
strategies.
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 88 - 88
Published: Jan. 23, 2025
There
is
ongoing
research
for
biomedical
applications
of
polyvinyl
alcohol
(PVA)-based
hydrogels;
however,
the
execution
this
has
not
yet
been
achieved
at
an
appropriate
level
commercialization.
Advanced
perception
necessary
design
and
synthesis
suitable
materials,
such
as
PVA-based
hydrogel
applications.
Among
polymers,
drawn
great
interest
in
owing
to
their
attractive
potential
with
characteristics
good
biocompatibility,
mechanical
strength,
apposite
water
content.
By
designing
approach
investigating
structure,
hydrogels
can
attain
superb
cytocompatibility,
flexibility,
antimicrobial
activities,
signifying
that
it
a
candidate
tissue
engineering
regenerative
medicine,
drug
delivery,
wound
dressing,
contact
lenses,
other
fields.
In
review,
we
highlight
current
progresses
on
explaining
diverse
usage
across
variety
areas.
We
explain
numerous
techniques
related
phenomena
based
these
materials.
This
review
may
stipulate
wide
reference
future
acumens
materials
extensive
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Gels,
Journal Year:
2024,
Volume and Issue:
10(5), P. 295 - 295
Published: April 25, 2024
Biomedicine
is
constantly
evolving
to
ensure
a
significant
and
positive
impact
on
healthcare,
which
has
resulted
in
innovative
distinct
requisites
such
as
hydrogels.
Chitosan-based
formulations
stand
out
for
their
versatile
utilization
drug
encapsulation,
transport,
controlled
release,
complemented
by
biocompatibility,
biodegradability,
non-immunogenic
nature.
Stimuli-responsive
hydrogels,
also
known
smart
have
strictly
regulated
release
patterns
since
they
respond
adapt
based
various
external
stimuli.
Moreover,
can
imitate
the
intrinsic
tissues’
mechanical,
biological,
physicochemical
properties.
These
characteristics
allow
stimuli-responsive
hydrogels
provide
cutting-edge,
effective,
safe
treatment.
Constant
progress
field
necessitates
an
up-to-date
summary
of
current
trends
breakthroughs
biomedical
application
chitosan-based
was
aim
this
review.
General
data
about
sensitive
ions,
pH,
redox
potential,
light,
electric
field,
temperature,
magnetic
are
recapitulated.
Additionally,
responsive
multiple
stimuli
mentioned.
Focusing
multifaceted
thoroughly
described.
The
vast
spectrum
encompasses
neurological
disorders,
tumors,
wound
healing,
dermal
infections.
Available
chitosan
strongly
support
idea
that
approaches
developing
novel
solutions
worth
improving.
present
paper
constitutes
valuable
resource
researchers
practitioners
currently
field.
